2016
DOI: 10.1016/j.freeradbiomed.2016.07.027
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Quercetin reduces manic-like behavior and brain oxidative stress induced by paradoxical sleep deprivation in mice

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Cited by 47 publications
(30 citation statements)
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“…Sleep-deprived animals did not display manic phenotype when they were pretreated with lithium or TMX or their combination [52]. Intraperitoneal administration of quercetin also prevented PSD-induced hyperlocomotion [53]. Interestingly, PSD-induced behavioral changes were reversed by a one-time administration of lithium about 1 h prior to behavioral testing without affecting baseline activity [48].…”
Section: Pkc Translocation and Activitymentioning
confidence: 99%
See 1 more Smart Citation
“…Sleep-deprived animals did not display manic phenotype when they were pretreated with lithium or TMX or their combination [52]. Intraperitoneal administration of quercetin also prevented PSD-induced hyperlocomotion [53]. Interestingly, PSD-induced behavioral changes were reversed by a one-time administration of lithium about 1 h prior to behavioral testing without affecting baseline activity [48].…”
Section: Pkc Translocation and Activitymentioning
confidence: 99%
“…Quercetin is a flavanol that contains a polyphenolic structure that scavenges free radicals and hence, acts as an antioxidant, and it also exhibits pleiotropic nonspecific PKC inhibition [127]. Kanazawa et al [53] showed that the quercetin administration was able to reverse the increase in lipid peroxidation in PFC, hippocampus, and striatum in a mouse model of mania induced by PSD. Quercetin also blocked methylphenidate-induced hyperlocomotion and oxidative stress in PFC, hippocampus, and striatum of mice [51].…”
Section: Downstream Targets Of Pkcmentioning
confidence: 99%
“…Our study demonstrated that RMFA exhibits AR inhibitory effects. Recently, quercetin reduces manic-like behavior and brain oxidative stress (Kanazawa et al 2016). Also it affects glutathione levels and redox in human aortic endothelial cells (Li et al 2016).…”
Section: Resultsmentioning
confidence: 99%
“…The simultaneous decrease in nNOS expression in whole brain homogenate at the protein and mRNA level probably further contributes to the phenomenon by removing neuroprotective basal NO formation. Interestingly, sleep deprivation has also been shown to impair the cerebral redox balance and to cause increased cerebral oxidative stress and abnormal (manic-like) behaviour and memory impairment, 58–60 conditions that are triggered by increased activity of the hypothalamic–pituitary–adrenal (HPA) axis, sympathetic activation and subsequent stress hormone production. In addition, Nox2 (gp91phox)-mediated increased oxidative stress was demonstrated to play an important role for learning and memory impairment.…”
Section: Discussionmentioning
confidence: 99%