Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: Slow release and high solubility

Abstract

a b s t r a c tElectrospinning of polyacrylic acid (PAA) nanofibres (NF) incorporating b-cyclodextrin inclusion complex (b-CD-IC) of quercetin (QU) was performed. Here, b-CD was used as not only the crosslinking agent for PAA nanofibres but also as a host molecule for inclusion of QU. The phase solubility test showed enhanced solubility of QU due to the inclusion complexation; in addition, the stoichiometry of QU/b-CD-IC was determined to be 1:1. Computational modelling studies confirmed that 1:1 and 1:2 complex formation are desirable; 1:1 complex formation was chosen to have higher weight loading of QU. SEM images showed that PAA/QU/b-CD-IC-NF were bead-free and uniform. XRD indicated that PAA/QU/b-CD-IC-NF were amorphous in nature without the crystalline peaks of QU. Comparative results revealed that the release profile of QU from PAA/QU/b-CD-IC-NF was much slower but greater in total than from PAA/QU/b-CD-IC-film. Moreover, high antioxidant activity and photostability of QU was achieved in PAA/QU/b-CD-IC-NF.

Antibacterial electrospun zein nanofibrous web encapsulating thymol/cyclodextrin-inclusion complex for food packaging

“…The zein-THY/c-CD-IC-NF (1:1) and zein-THY/ c-CD-IC-NF (2:1) exhibited a broad XRD pattern without the sharp crystalline peaks of THY/c-CD-IC, possibly due to the amorphous distribution of THY/c-CD-IC in the fiber matrix. The similar situation in which CD-ICs were distributed amorphously was observed when quercetin, a crystalline molecule, was included into b-CD and then incorporated into electrospun nanofibers (Aytac et al, 2016b). Similarly, THY in the zein-THY-NF sample was also distributed in the zein fiber matrix without any crystal formation.…”

“…Hence, electrospun nanofibers have the potential to be used in food packaging applications (Vega-Lugo & Lim, 2009;Wen, Zhu, Feng et al, 2016;. Moreover, CD-ICs of various compounds including food additives, essential oils, antioxidant and antibacterial agents might be incorporated into electrospun nanofibers for enhancing solubility and thermal stability, controlling release and prolonging shelf life Aytac, Dogan, Tekinay, & Uyar, 2014;Aytac, Kusku, Durgun, & Uyar, 2016a, 2016bAytac, Sen, Durgun, & Uyar, 2015;Kayaci & Uyar, 2012;Uyar, Hacaloglu, & Besenbacher, 2011;Uyar, Nur, Hacaloglu, & Besenbacher, 2009).…”

Effect of cyclodextrin complexation on solubility of novel anti-Alzheimer 1,2,4-thiadiazole derivative

“…The obtained results point out that amorphization of I occurs during the treatment and complex formation with CDs. It is believed [15] that guest molecules cannot form crystals when inclusion complexes are formed, since they are separated from each other by the CD cavity. The 13 C MAS CP/TOSS NMR spectra recorded for samples containing I and b-CD are shown in Fig.…”

Core-Shell Nanostructures for Drug Delivery and Theranostics

“…CD-ICs provide enhancement in the solubility of hydrophobic molecules owing to the hostÀguest interaction formed between CD and drugs in appropriate polarity and dimension. There are several studies in the literature aiming to improve the solubility and controlling the release of numerous molecules by incorporating CD-IC of molecules such as vanillin [31], eugenol [32], allyl isothiocyanate [33], sulfisoxazole [34], quercetin [35], gallic acid [36], α-tocopherol [37,38], and thymol [39] solutions and ultimately nanofibers were produced via electrospinning. Moreover, there are also studies in which CDs was used as template and host simultaneously for the IC of triclosan [40], geraniol [41], vanillin [42], limonene [43], sulfisoxazole [44], and linalool [45].…”