Quinazoline: An update on current status against convulsions

Cheke, Rameshwar S.; Shinde, Sachin D.; Ambhore, Jaya P.; Chaudhari, Suraj R.; Bari, Sanjay B.

doi:10.1016/j.molstruc.2021.131384

Cited by 19 publications

(12 citation statements)

References 89 publications

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“…Heterocyclic entities are denoted as a vital class of organic compounds with wide biological and pharmacological potency [ 1 , 2 ]. In view of wide-ranging biological activities, these heterocyclic analogues, either individually or as fused forms, are consistently utilized by scientists and research groups for the design of the novel candidates [ 3 ]. Among them, isatin, or (1 H -indole-2,3-dione), has a wide spectrum of pharmacological potential and is thus appraised as a fortunate bioactive heterocyclic moiety.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery

Cheke¹,

Patil²,

Firke

et al. 2022

Pharmaceuticals

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Isatin (1H indole 2, 3-dione) is a heterocyclic, endogenous lead molecule recognized in humans and different plants. The isatin nucleus and its derivatives are owed the attention of researchers due to their diverse pharmacological activities such as anticancer, anti-TB, antifungal, antimicrobial, antioxidant, anti-inflammatory, anticonvulsant, anti-HIV, and so on. Many research chemists take advantage of the gentle structure of isatins, such as NH at position 1 and carbonyl functions at positions 2 and 3, for designing biologically active analogues via different approaches. Literature surveys based on reported preclinical, clinical, and patented details confirm the multitarget profile of isatin analogues and thus their importance in the field of medicinal chemistry as a potent chemotherapeutic agent. This review represents the recent development of isatin analogues possessing potential pharmacological action in the years 2016–2020. The structure–activity relationship is also discussed to provide a pharmacophoric pattern that may contribute in the future to the design and synthesis of potent and less toxic therapeutics.

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Section: Introductionmentioning

confidence: 99%

Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery

Cheke¹,

Patil²,

Firke

et al. 2022

Pharmaceuticals

Self Cite

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“…The quantum dots protect their optical properties and have an exceptionally high relaxivity. Ligands can be coupled to these QDs using maleimide or other utilitarian gatherings [49][50][51] .…”

Section: Bimodal Molecular Imagingmentioning

confidence: 99%

Quantum Dots: A New Hope for the Pharmaceutical Field

Bhurbhure

Ghormade

Katekar³

et al. 2022

J. Drug Delivery Ther.

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Quantum dots (QDs) are nanoparticles that have been developed for a number of biological and biomedical applications, such as drug delivery and simultaneous imaging of several cells. As a result of their unique physicochemical features, QDs have shown remarkable potential in receptor-based targeting. Functionalized QDs (f-QDs) are nano-sized smart systems that can deliver a wide spectrum of bioactive. Surface modified fluorescent carbon QDs has received interest as a targeting ligand for achieving cellular targeting with increased specificity. Several surface-designed and conjugated fluorescent carbon QDs are currently being investigated for cancer treatment, and the results are awaited with bated breath. This review emphasizes different synthesis methods, their characterizations, and different applications of QDs in cancer therapies. Keywords: Quantum dots, Synthesis, Medical applications.

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“…As per the literature assessment, different dosages for Lamivudine were available [13][14][15][16][17][18] . Also, some floating systems were reported for Lamivudine 19 .…”

Section: Figure 1: Structure Of Lamivudinementioning

confidence: 99%

Formulation and Evaluation of Gastroretentive Floating Microspheres loaded with Lamivudine

Karosiya¹,

Vaidya²,

Bhajipale³

et al. 2022

J. Drug Delivery Ther.

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Some drugs give poor absorption because of a narrow absorption window in the gastrointestinal tract (GIT). To improve the absorption of such drugs in GIT, gastro retentive drug delivery techniques play a vital role. Lamivudine is an antiviral medicine. The floating gastroretentive microspheres were prepared to attain an extended therapeutic action of Lamivudine. Floating microspheres were formulated to prolong the gastric retention and enhancement of bioavailability of the drug candidate. The floating microspheres were formulated using guar gum and xanthan gum as natural polymers. The proposed floating system was evaluated by preliminary evaluation parameters, micrometric investigation as well as Particle size investigation, Percentage yield of microspheres, Drug entrapment efficiency, In-vitro drug release studies, and their kinetics. The formulated microsphere is evaluated in the form of its stable nature. The formulated microsphere was found to be smooth, spherical, and slightly aggregated containing guar gum whereas xanthan gum containing microsphere was found porous, irregular, grossly, and discrete globular. Formulated microsphere gives a good percentage of drug entrapment and practical yields. The floating microsphere prolonged the drug release by up to 12 hrs. The IR spectroscopy of the prepared formulation was shown that the chemical structure of the Lamivudine was unchanged. The prepared lamivudine microspheres presented gastro retentive and extended-release properties. Keywords: Lamivudine; Microspheres; Narrow absorption window; Floating system

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Quinazoline: An update on current status against convulsions

Cited by 19 publications

References 89 publications

Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery

Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery

Quantum Dots: A New Hope for the Pharmaceutical Field

Formulation and Evaluation of Gastroretentive Floating Microspheres loaded with Lamivudine

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