Quinazolinone Sulfonamides. A New Class of Diuretic Agents¹

A new and facile CuCl2·2H2O-catalyzed one-pot three-component synthesis for quinazolines

“…There are many drugs as staple features available in the market constituted of quinazoline skeletons [11][12][13][14][15][16][17]. Quinazoline nuclei have been explored to have antiallergic [18], anti-inflammatory [19], anticonvulsant [20], antihyperlipidemic [21], and antileishmanial [22] properties.…”

Synthesis and Characterization of Bis-quinazolines from Linear Tetra-amines Involving 2-(Aminomethyl)benzenamine with Aldehydes

“…Quinazolines have been widely studied in recent years due to their wide range of chemotherapeutic activities including antiviral [1], antibacterial [2,3], antifungal [4,5], antimalarial [6], antitumorals [7][8][9], antihypertensive [10], diuretic [11,12], inhibitors of cyclin-dependent kinases [13], anticonvulsant [14], ghrelin receptor antagonists [15], antiinflammatory, analgesic, and COX-II inhibitors [16,17]. Hence, the synthesis and research of new quinazolines is of great interest.…”

Synthesis of 3H‐Quinazolin‐4‐ones and 4H‐3,1‐Benzoxazin‐4‐ones via Benzylic Oxidation and Oxidative Dehydrogenation using Potassium Iodide‐tert‐Butyl Hydroperoxide

“…[1] 3H-Quinazolin-4-ones exhibit a broad spectrum of biological and pharmaceutical activities including antihypertensive, [2] antidiabetic, [3] anti-inflammatory, [4] antibacterial, [5] anticonvulsant, [6] antitumor, [7] central nervous system (CNS) depressant [8] and diuretic [9] activities. Along similar lines, 2-substituted-4H-3,1-benzoxazin-4-ones compounds act as chymotrypsin inactivators, [10a] inhibitors of human leukocyte elastase [10b,c] and serine protease.…”