Quinoline: A versatile heterocyclic

Abstract

Quinoline or 1-aza-naphthalene is a weak tertiary base. Quinoline ring has been found to possess antimalarial, anti-bacterial, antifungal, anthelmintic, cardiotonic, anticonvulsant, anti-inflammatory, and analgesic activity. Quinoline not only has a wide range of biological and pharmacological activities but there are several established protocols for the synthesis of this ring. The article aims at highlighting these very diversities of the ring.

Synthesis of some quinoline-pyrazoline-based naphthalenyl thiazole derivatives and their evaluation as potential antimicrobial agents

“…The FTIR spectra in KBr were generated using a 5PC FT-IR spectrophotometer (Nicolet, Browser Morner, USA). The 1 H-NMR and 13 C-NMR spectra were generated using a DRX-300 FT NMR (Germany, Bruker) spectrophotometer. Mass spectra were generated on a mass spectrometer (70 eV, Jeol-JMS-D-300, Japan).…”

“…Recently, review articles mentioning the usefulness of thiazolyl heterocycles [11,12], quinolinyl heterocycles [13,14], and pyrazolinyl heterocycles [15,16] as analgesic, anti-inflammatory, antibacterial, antifungal, antiviral, antiparasitic, anticoagulant, anti-Parkinson's Disease, anticancer, antioxidants, antidiabetic, CNS depressant, and antimalarial have been published. Recently, thiazolyl pyrazoline derivatives (I) and quinolinylpyrazoline-based thiazole derivatives (II) have been postulated as templates for the development of new antimicrobial agents [17,18] ( Figure 1).…”

Synthesis and Characterization of Antimicrobial Activity of Quinoline Derivatives

“…Chemistry of Quinoline derivatives has been of increasing Quinoline family compounds are widely used as a parent compound to make drugs, fungicides, biocides, alkaloids, dyes, rubber, chemicals, flavoring agents, antiseptic. [1] Quinoline derivatives have been reported anti-inflammatory [2] , antibacterial [3,4,5] , antifungal [6,7] , antiallergy [8] , antidepressant [9] , antiasthmatic [10] , antimalarial [11][12][13] , antiviral [14,15] , antitumour [16] , neuroleptic activity [17] , antihypertensive [18,19] , cytotoxic [20][21][22] , antihistamine [23] , CVS [24] , antiseptic, analgesic, antihelmintic [25] , hypnotic, sedative and CNS [26] , Bronchodilator activities [27] The present work we have attempted to combine the 3-formyl-6-nitroquinoline-2-thione with various aryl amines to get some novel 3-formyl-6-nitroquinoline-2-thionederivatives and screened for their possible anti-oxidant and wound healing properties.…”

Antibacterial Screening of some Heterocyclic Compounds Containing Quinoline Nucleus

“…Quinolines and their derivatives are very important compounds because of their wide occurrence in natural products [1,2] and biologically active compounds [3][4][5][6][7][8]. These derivatives are also used for the preparation of nano-and meso structures having enhanced electronic and photonic properties [9,10] and are known to have applications as pharmaceuticals, agrochemicals and synthetic building blocks [11]. Quinolines have been found to possess antimalarial, anti-bacterial, antifungal, antihelmintic, cardiotonic, anticonvulsant, anti-inflammatory, and analgesic activity [12][13][14][15][16][17][18].…”