Quinoline, with the active site of 8‐hydroxyl, efficiently inhibits <i>Micropterus salmoides</i> rhabdovirus (MSRV) infection in vitro and in vivo

Li, Bo-Yang; Yang, Fei; Zhang, Zhongyu; Shen, Yufeng; Wang, Tao; Zhao, Liang; Qin, Jia-Cheng; Ling, Fei; Wang, Gao‐Xue

doi:10.1111/jfd.13615

Cited by 21 publications

(9 citation statements)

References 61 publications

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“…In a separate study by Li et al, the anti‐MSRV effects of 22 quinoline derivatives were evaluated in GCO cells. Notably, 8‐hydroxyquinoline exhibited strong inhibition with an IC 50 value of 4.66 μM at 48 h, resulting in a 99.3% decrease in MSRV nucleoprotein gene expression levels 79 . Moreover, ursolic acid was found to inhibit MSRV replication in GCO cells with an IC 50 value of 5.55 μM 80 …”

Section: Antiviral Effect Of Medicinal Plants and Their Active Ingred...mentioning

confidence: 99%

“…Notably, 8-hydroxyquinoline exhibited strong inhibition with an IC 50 value of 4.66 μM at 48 h, resulting in a 99.3% decrease in MSRV nucleoprotein gene expression levels. 79 Moreover, ursolic acid was found to inhibit MSRV replication in GCO cells with an IC 50 value of 5.55 μM. 80 MSRV is highly contagious and can spread rapidly among bass populations through water and contaminated equipment, which can result in significant economic losses in the aquaculture industry.…”

Section: Antiviral Effect Of Medicinal Plants and Their Active Ingred...mentioning

confidence: 99%

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The antiviral activity of currently used medicinal plants in aquaculture and structure–activity relationship of their active ingredients

Zhang

Shan

et al. 2023

Reviews in Aquaculture

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Aquaculture is an important source of high‐quality protein and plays a crucial role in ensuring global food security. However, viral diseases have caused significant damage to aquaculture production, making it necessary to develop effective measures to treat them. Although drugs are commonly used to treat viral diseases, recent studies have shown that crude extracts of medicinal plants and their active ingredients have potential applications in the treatment of aquatic viral diseases. Furthermore, natural small molecule compounds from herbs could be used as lead compounds to develop more potent anti‐aquatic virus derivatives. As such, there is an urgent need to develop and apply drugs for the treatment of viral disease outbreaks in aquaculture. In this review, we summarize previous studies on the efficacy of different agents used as antiviral drugs in aquaculture, with a focus on their protective effects. Additionally, we highlight the potential of active natural compounds isolated from medicinal plants, which could serve as lead compounds for developing aquatic‐specific drugs. However, the relationship between the structure of a compound and its antiviral activity in aquaculture has not been clearly elucidated, posing a challenge for further drug optimisation. Therefore, this study also analyses the structure–activity relationship of several reported lead compounds and their derivatives in aquaculture, providing a reference for subsequent drug development efforts.

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Section: Antiviral Effect Of Medicinal Plants and Their Active Ingred...mentioning

confidence: 99%

Section: Antiviral Effect Of Medicinal Plants and Their Active Ingred...mentioning

confidence: 99%

The antiviral activity of currently used medicinal plants in aquaculture and structure–activity relationship of their active ingredients

Zhang

Shan

et al. 2023

Reviews in Aquaculture

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“…8-Hydroxyquinoline derivatives have been reported to have wide biological activities, such as anticancer activity, antiviral activity, antibacterial activity, and antifungal activity . Two well-known members of this family, clioquinol and nitroxoline are broad-spectrum antimicrobial agents (Figure ).…”

Section: Introductionmentioning

confidence: 99%

Discovery of Novel 8-Hydroxyquinoline Derivatives with Potent In Vitro and In Vivo Antifungal Activity

Li,

Wu,

Wang

et al. 2023

J. Med. Chem.

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Fungal pathogens can cause life-threatening infections, yet current antifungals are inadequate at treating many of these, highlighting the importance of novel drug discovery. Here, we report hit compound L14, a novel 8-hydroxyquinoline derivative with potent and broad-spectrum antifungal activity. In vitro experiments exhibited that L14 had better activity and lower cytotoxicity than that of clioquinol and showed synergy in combination with fluconazole (FLC). In a Candida albicans-infected murine model, L14 at 2 mg/kg showed better in vivo efficacy than clioquinol at reducing fungal burden and extending the survival of C. albicans-infected mice. In addition, L14 alone or in combination with FLC had significant inhibitory activity against hypha and biofilm formation. Overall, our data indicated that 8-hydroxyquinoline derivative L14 has favorable pharmacokinetics and acceptable safety profiles and could be further investigated as a promising antifungal hit compound.

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“…The DNA vaccine and subunit vaccine prepared with glycoprotein of MSRV had good immune protection effects against MSRV infection (Guo et al., 2020; Xu et al., 2022; Yang, Guo, et al., 2022; Yang, Xu, et al., 2022). In addition, Chinese herbal medicine (magnolol derivatives) and antiviral drug (ribavirin and 8‐hydroxyquinoline) could decrease tissue viral nucleic acids, and improve the survival rate of largemouth bass after MSRV infection (Jin et al., 2022; Li et al., 2022; Yang et al., 2021). While the efficacy and mechanism of disinfectants against MSRV in water are still lacking.…”

Section: Introductionmentioning

confidence: 99%

Experimental evidence of effective disinfectant to control the transmission of Micropterus salmoides rhabdovirus

He,

Zhu,

Chen

et al. 2023

Journal of Fish Diseases

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Micropterus salmoides rhabdovirus (MSRV) is a significant pathogen that causes high morbidity and mortality in largemouth bass, leading to enormous economic losses for largemouth bass aquaculture in China. The aim of this study was to investigate the efficacy of four disinfectants (potassium permanganate, glutaraldehyde, trichloroisocyanuric acid and povidone iodine) on MSRV, to control the infection and transmission of MSRV in largemouth bass aquaculture. The disinfectants were tested at different concentrations (5, 25, 50, 100 and 500 mg/L) prepared with distilled water for 30 min contact time, and the viral nucleic acid was quantified using qPCR and the infectivity was tested by challenge experiment. Potassium permanganate at 5–500 mg/L, glutaraldehyde at 500 mg/L, trichloroisocyanuric acid at 50–500 mg/L and povidone iodine at 500 mg/L concentration could effectively decrease the virus nucleic acid, and the survival rate of largemouth bass juveniles after challenge experiment increased significantly from 3.7% ± 6.41% to 33.33 ± 11.11% – 100%. Moreover, the minimum effective time of 5 mg/L potassium permanganate was further studied at 2, 5, 10 and 20 min contact time. The viral nucleic acid decreased significantly at 5–20 min exposure time, and the survival rate increased significantly from 7.41% ± 6.41% to 77.78 ± 11.11% – 100%. The median lethal concentration (LC50) values of potassium permanganate were 10.64, 6.92 and 3.7 mg/L at 24, 48 and 96 h, respectively. Potassium permanganate could be used for the control of MSRV in the cultivation process; the recommended concentration is 5 mg/L and application time should be less than 24 h. The results could be applied to provide a method to control the infection and transmission of MSRV in water, and improve the health status of largemouth bass.

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Quinoline, with the active site of 8‐hydroxyl, efficiently inhibits Micropterus salmoides rhabdovirus (MSRV) infection in vitro and in vivo

Cited by 21 publications

References 61 publications

The antiviral activity of currently used medicinal plants in aquaculture and structure–activity relationship of their active ingredients

The antiviral activity of currently used medicinal plants in aquaculture and structure–activity relationship of their active ingredients

Discovery of Novel 8-Hydroxyquinoline Derivatives with Potent In Vitro and In Vivo Antifungal Activity

Experimental evidence of effective disinfectant to control the transmission of Micropterus salmoides rhabdovirus

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