Quinoxaline-functionalized silver nanoparticles as chromogenic probe for the multiple selective detection of cysteine, Mg2+ and Sn2+ in aqueous solution

Neri, Jannyely M.; Latocheski, Eloah; Araujo, Jhudson G L de; Lima, Rayane P. de; Cavalcanti, Lívia N.; Neves, Ana Carolina de Oliveira; Gasparotto, Luiz H. S.; Domingos, Josiel B.; Menezes, Fabrício G.

doi:10.1016/j.snb.2021.130743

Cited by 16 publications

(1 citation statement)

References 43 publications

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“…They used these conjugates to target cancer cells, because compounds with a quinoxaline motif can bind to phosphatidylinositol-4,5-bisphosphate 3-kinases (PI3Ks) and these enzymes are overexpressed in some types of neoplasms ( Araújo et al, 2019 ). Quinoxaline derivatives have also been used to functionalize silver and gadolinium-based nanoparticles and were shown to give excellent stability, while providing functional groups such as -NH 2 or -OH, which could serve for the binding of different ligands ( Morlieras et al, 2013 ; Neri et al, 2021 ).…”

Section: Functionalization Methodsmentioning

confidence: 99%

Latest Trends in Lateral Flow Immunoassay (LFIA) Detection Labels and Conjugation Process

Mirica

Stan²,

Chelcea³

et al. 2022

Front. Bioeng. Biotechnol.

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LFIA is one of the most successful analytical methods for various target molecules detection. As a recent example, LFIA tests have played an important role in mitigating the effects of the global pandemic with SARS-COV-2, due to their ability to rapidly detect infected individuals and stop further spreading of the virus. For this reason, researchers around the world have done tremendous efforts to improve their sensibility and specificity. The development of LFIA has many sensitive steps, but some of the most important ones are choosing the proper labeling probes, the functionalization method and the conjugation process. There are a series of labeling probes described in the specialized literature, such as gold nanoparticles (GNP), latex particles (LP), magnetic nanoparticles (MNP), quantum dots (QDs) and more recently carbon, silica and europium nanoparticles. The current review aims to present some of the most recent and promising methods for the functionalization of the labeling probes and the conjugation with biomolecules, such as antibodies and antigens. The last chapter is dedicated to a selection of conjugation protocols, applicable to various types of nanoparticles (GNPs, QDs, magnetic nanoparticles, carbon nanoparticles, silica and europium nanoparticles).

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Section: Functionalization Methodsmentioning

confidence: 99%