Quiz Page June 2011

Rapid Recovery from Acute Kidney Injury in a Patient with Metformin-associated Lactic Acidosis and Hypothermia

“…Her clinical presentation and responses to continuous renal replacement therapy (Figure 1) are consistent with metformin-associated lactic acidosis. 3 It is likely that she developed acute kidney injury due to volume depletion initially triggered by urinary tract infection and worsened by an angiotensin-converting enzyme inhibitor. Metformin was therefore accumulated due to poor renal clearance and induced severe toxicity.…”