Quorum Sensing Contributes to Activated IgM-Secreting B Cell Homeostasis

Montaudouin, Caroline; Anson, Marie; Hao, Yi; Duncker, Susanne V.; Fernandez, Tahía D.; Gaudin, Emmanuelle; Ehrenstein, Michael R.; Kerr, William G.; Colle, Jean‐Hervé; Bruhns, Pierre; Daëron, Marc; Freitas, António A.

doi:10.4049/jimmunol.1200907

Cited by 25 publications

(27 citation statements)

References 48 publications

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“…For instance, previously established plasma cells and those newly originated by antigen immunization may compete for niches and factors. It is interesting to consider whether the intrinsic state of the plasma cells, long-lived vs short-lived, ontogeny, differentiation and T-cell help may alter their response to T 3 , possibly favoring plasma cells normally present under physiological conditions, such as those involved in the production of natural antibodies (Gronwall et al 2012, Ouchida et al 2012, Montaudouin et al 2013. It would be also relevant to investigate the effects of T 3 in mouse models of lupus-like autoimmune diseases, characterized by elevated levels of polyclonal autoantibodies (Shlomchik et al 1987, Chan et al 1999.…”

Section: B220mentioning

confidence: 99%

High levels of circulating triiodothyronine induce plasma cell differentiation

Bloise

Oliveira

Nóbrega

et al. 2013

Journal of Endocrinology

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The effects of hyperthyroidism on B-cell physiology are still poorly known. In this study, we evaluated the influence of high-circulating levels of 3,5,3 0 -triiodothyronine (T 3 ) on bone marrow, blood, and spleen B-cell subsets, more specifically on B-cell differentiation into plasma cells, in C57BL/6 mice receiving daily injections of T 3 for 14 days. As analyzed by flow cytometry, T 3 -treated mice exhibited increased frequencies of pre-B and immature B-cells and decreased percentages of mature B-cells in the bone marrow, accompanied by an increased frequency of blood B-cells, splenic newly formed B-cells, and total CD19C B-cells. T 3 administration also promoted an increase in the size and cellularity of the spleen as well as in the white pulp areas of the organ, as evidenced by histological analyses. In addition, a decreased frequency of splenic B220 C cells correlating with an increased percentage of CD138 C plasma cells was observed in the spleen and bone marrow of T 3 -treated mice. Using enzyme-linked immunospot assay, an increased number of splenic immunoglobulinsecreting B-cells from T 3 -treated mice was detected ex vivo. Similar results were observed in mice immunized with hen egg lysozyme and aluminum adjuvant alone or together with treatment with T 3 . In conclusion, we provide evidence that high-circulating levels of T 3 stimulate plasmacytogenesis favoring an increase in plasma cells in the bone marrow, a longlived plasma cell survival niche. These findings indicate that a stimulatory effect on plasma cell differentiation could occur in untreated patients with Graves' disease.

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Section: B220mentioning

confidence: 99%

High levels of circulating triiodothyronine induce plasma cell differentiation

Bloise

Oliveira

Nóbrega

et al. 2013

Journal of Endocrinology

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“…They also develop autoantibodies and severe lupus-like disease. [22 • ,24,25 •• ]. B cells lacking SHIP1 display enhanced BCR-signaling and proliferation [21,22 • ] and altered BCR clustering [23].…”

Section: Ship1 and Ship2mentioning

confidence: 99%

Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells

Bounab¹,

Getahun²,

Cambier³

et al. 2013

Current Opinion in Immunology

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Recent progress has begun to reveal the often complex and changing roles of phosphotyrosine and phosphoinositide phosphatases in regulation of immunoreceptor signaling. The resultant confusion has been further increased by discoveries of new players. Here we provide a review of recent progress in defining the roles of these enzymes in immunoreceptor-dependent mast cell, T cell and B cell activation.

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“…Beyond microbiology, recent studies of mammalian systems also suggest that QS-like strategies are involved in the homeostatic control of the immune response as well as cell differentiation processes in cancer development (117)(118)(119)(120)(121).…”

Section: Figmentioning

confidence: 99%

Core Principles of Bacterial Autoinducer Systems

Hense

Schuster

2015

Microbiol Mol Biol Rev

163

156

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SUMMARY Autoinduction (AI), the response to self-produced chemical signals, is widespread in the bacterial world. This process controls vastly different target functions, such as luminescence, nutrient acquisition, and biofilm formation, in different ways and integrates additional environmental and physiological cues. This diversity raises questions about unifying principles that underlie all AI systems. Here, we suggest that such core principles exist. We argue that the general purpose of AI systems is the homeostatic control of costly cooperative behaviors, including, but not limited to, secreted public goods. First, costly behaviors require preassessment of their efficiency by cheaper AI signals, which we encapsulate in a hybrid “push-pull” model. The “push” factors cell density, diffusion, and spatial clustering determine when a behavior becomes effective. The relative importance of each factor depends on each species' individual ecological context and life history. In turn, “pull” factors, often stress cues that reduce the activation threshold, determine the cellular demand for the target behavior. Second, control is homeostatic because AI systems, either themselves or through accessory mechanisms, not only initiate but also maintain the efficiency of target behaviors. Third, AI-controlled behaviors, even seemingly noncooperative ones, are generally cooperative in nature, when interpreted in the appropriate ecological context. The escape of individual cells from biofilms, for example, may be viewed as an altruistic behavior that increases the fitness of the resident population by reducing starvation stress. The framework proposed here helps appropriately categorize AI-controlled behaviors and allows for a deeper understanding of their ecological and evolutionary functions.

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Quorum Sensing Contributes to Activated IgM-Secreting B Cell Homeostasis

Cited by 25 publications

References 48 publications

High levels of circulating triiodothyronine induce plasma cell differentiation

High levels of circulating triiodothyronine induce plasma cell differentiation

Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells

Core Principles of Bacterial Autoinducer Systems

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