Quorum sensing for population-level control of bacteria and potential therapeutic applications

Wu, Shengbo; Liu, Jiaheng; Liu, Chunjiang; Yang, Aidong; Qiao, Jianjun

doi:10.1007/s00018-019-03326-8

Cited by 135 publications

(90 citation statements)

References 237 publications

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“…The discovery of control strategies for quorum quenching diseases in recent years has provided new possibilities for overcoming and solving the problem of microbial resistance [101,102]. By interfering with the QS system of specific microorganisms, hindering the exchange of information between microorganisms, and reducing the expression level of hazard factors, this phenomenon is called quorum quenching (QQ) [103,104]. The properties of quorum quenching molecular roles (chemical compounds, enzymes), modes of action (competition, inhibition, QS signal interdict, etc.…”

Section: New Strategy For Preventive Treatment Of Microbial Resistancementioning

confidence: 99%

Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria

2020

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Quorum sensing is a cell-to-cell communication system that exists widely in the microbiome and is related to cell density. The high-density colony population can generate a sufficient number of small molecule signals, activate a variety of downstream cellular processes including virulence and drug resistance mechanisms, tolerate antibiotics, and harm the host. This article gives a general introduction to the current research status of microbial quorum-sensing systems, focuses on the role of quorum-sensing systems in regulating microbial resistance mechanisms, such as drug efflux pump and microbial biofilm formation regulation, and discusses a new strategy for the treatment of drug-resistant bacteria proposed by using quorum quenching to prevent microbial resistance.

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Section: New Strategy For Preventive Treatment Of Microbial Resistancementioning

confidence: 99%

Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria

2020

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“…When the microbial population reaches a certain density level, the concentration of signaling molecules reaches a threshold value. By signal transduction through related proteins, including receptor protein kinases, signals are transmitted across the cells, thus affecting the expression of specific genes and regulating the physiological characteristics of microbial populations [44][45][46]. Bacteria use quorum sensing for cell-to-cell communication and coordination of activities in the complex environment, which enables the entire bacterial population to survive [47][48][49].…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Landscape of Intracellular Brucella ovis Surviving in RAW264.7 Macrophage Immune System

Zheng

et al. 2020

Inflammation

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Brucella ovis infection results in genital damage and epididymitis in rams, placental inflammation and rare abortion in ewes, and neonatal mortality in lambs. However, the mechanism underlying B. ovis infection remains unclear. In the present study, we used prokaryotic transcriptome sequencing to identify the differentially expressed genes (DEGs) between wild-type B. ovis and intracellular B. ovis in RAW264.7 macrophages. Gene ontology (GO) term enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed, and quantitative reverse transcriptase PCR (qRT-PCR) was used to validate the top 10 upregulated and downregulated DEGs. The results showed that 212 genes were differentially expressed, including 68 upregulated and 144 downregulated genes, which were mainly enriched in 30 GO terms linked to biological process, cellular component, and molecular function. KEGG analysis showed that the DEGs were enriched in the hypoxia-inducible factor 1 (HIF-1) signaling pathway, mitogen-activated protein kinase (MAPK) signaling pathway, beta-alanine metabolism, and quorum sensing pathway. BME_RS01160, BME_RS04270, BME_RS08185, BME_RS12880, BME_RS25875, predicted_RNA865, and predicted_RNA953 were confirmed with the transcriptome sequencing data. Hence, our findings not only reveal the intracellular parasitism of B. ovis in the macrophage immune system, but also help to understand the mechanism of chronic B. ovis infection.

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“…2001; Wu et al . 2019). The quorum‐quenching enzymes are enzymes that inactivate the bacteria QS system, while QS inhibitors are the chemicals that interrupt the QS pathway.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Incidence of antibiotic resistance in Vibrio spp

Loo

Letchumanan

Law

et al. 2020

Reviews in Aquaculture

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Vibrio species is a common natural inhabitant of brackish and saltwater. Vibrio sp. includes not only emerging pathogens but also well‐known and emerged pathogens, such as V. cholerae, V. parahaemolyticus and V. vulnificus. Although it is often harmless, pathogenic strains which could cause serious food‐borne illnesses/outbreaks in both humans and animals have been identified. Vibrio infection is usually self‐limiting and requires no clinical treatment. However, antibiotics are still required to treat severe cases of Vibrio infection. Recent reports have highlighted a rise in the presence of antibiotic‐resistant Vibrio in the environment. This hampers the clinical treatment of Vibrio infection and has been linked to the imprudent use of antibiotics in various fields such as human medicine, agriculture and animal husbandry. As a result, it has greatly jeopardized food security, threatened public health and impugned the growth of economy. Food is a potential vehicle of antibiotic‐resistant Vibrio where the resistant genes are transmitted to humans via ingestion of contaminated food. Hence, the surveillance, monitoring and management of antibiotic patterns of Vibrio are important for clinical treatment. This review focuses on different trends and global patterns of antibiotic resistance of Vibrio.

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Quorum sensing for population-level control of bacteria and potential therapeutic applications

Cited by 135 publications

References 237 publications

Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria

Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria

Transcriptome Landscape of Intracellular Brucella ovis Surviving in RAW264.7 Macrophage Immune System

Incidence of antibiotic resistance in Vibrio spp

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