Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments.

Abstract

Abstract. We report an essential role for the ras-

Rab11 Is Required for Trans-Golgi Network–to–Plasma Membrane Transport and a Preferential Target for GDP Dissociation Inhibitor

“…Taken together these data suggest a possible role for rab11 in the budding of a subset of TGN vesicles. Although rab proteins have been primarily associated with vesicletargeting functions, there are a number of examples in which the rab proteins have been suggested to influence vesicle budding (Plutner et al, 1991;Riederer et al, 1994;Jedd et al, 1995Jedd et al, , 1997. Perhaps the most compelling evidence derives from in vitro assays showing a direct role for rab5 in coated vesicle formation at the plasma membrane (McLauchlan et al, 1998).…”

“…Along the exocytic pathway, endoplasmic reticulum (ER)-to-Golgi transport is regulated by two rab proteins, rab1 and rab2, and intra-Golgi transport depends on the action of rab6 (Plutner et al, 1991;Tisdale et al, 1992;Martinez et al, 1994). Transport from the trans-Golgi network (TGN) to the cell surface requires rab8 and possibly rab11 Urbé et al, 1993).…”

Regulation of the Human Ether-a-go-go-related Gene (hERG) Channel by Rab4 Protein through Neural Precursor Cell-expressed Developmentally Down-regulated Protein 4-2 (Nedd4-2)

“…It has been shown that Rab1 and Rab2 regulate endoplasmic retic-* This work was supported by the Canadian Institutes of Health Research ulum-to-Golgi transport (18,19); Rab4 is localized at the early sorting endosome and is responsible for rapid/direct recycling from early endosomes to the cell surface (20,21); Rab5 regulates the fusion between endocytic vesicles and early endosomes (22,23); Rab7 has primarily been implicated in the transport from early to late endosomes and plays an essential role in the maintenance of the perinuclear lysosome compartment (17,22,24); and Rab11 is involved in mediating slow recycling from endosomes to the plasma membrane (25).…”

MicroRNA

“…25 RAB1B is a small GTPase from Ras super family that has been demonstrated to modulate autophagic activity in HeLa cells through the regulation of autophagosome formation. 26 Rab1B has been shown to regulate vesicle trafficking at multiple stages and directly impact autophagy 27,28 and was found to be overexpressed in liver cancer. 29 Ectopic expression of miR-502 in HCT-116 cells interrupted autophagic flux under acute and prolonged nutrient starvation.…”