2020
DOI: 10.1038/s41598-020-74013-z
|View full text |Cite
|
Sign up to set email alerts
|

Rab35 and its effectors promote formation of tunneling nanotubes in neuronal cells

Abstract: Tunneling nanotubes (TNTs) are F-actin rich structures that connect distant cells, allowing the transport of many cellular components, including vesicles, organelles and molecules. Rab GTPases are the major regulators of vesicle trafficking and also participate in actin cytoskeleton remodelling, therefore, we examined their role in TNTs. Rab35 functions with several proteins that are involved in vesicle trafficking such as ACAP2, MICAL-L1, ARF6 and EHD1, which are known to be involved in neurite outgrowth. Her… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

1
39
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
5
2

Relationship

2
5

Authors

Journals

citations
Cited by 36 publications
(40 citation statements)
references
References 71 publications
1
39
0
Order By: Relevance
“…Here, we will focus on proteins and signaling pathways linked to dynamic actin networks which function in the formation and regulation of other common membranous protrusions, such as filopodia (Ljubojevic et al , 2021). Molecules deployed to form TNTs via membrane recycling (e.g., different Ras‐related proteins in brain (Rabs) and M‐Sec, are described in detail elsewhere (Hase et al , 2009; Marzo et al , 2012; Dubois et al , 2018; Dupont et al , 2018; Zhu et al , 2018; Bhat et al , 2020)).…”
Section: An Overview Of Tunneling Nanotubesmentioning
confidence: 99%
“…Here, we will focus on proteins and signaling pathways linked to dynamic actin networks which function in the formation and regulation of other common membranous protrusions, such as filopodia (Ljubojevic et al , 2021). Molecules deployed to form TNTs via membrane recycling (e.g., different Ras‐related proteins in brain (Rabs) and M‐Sec, are described in detail elsewhere (Hase et al , 2009; Marzo et al , 2012; Dubois et al , 2018; Dupont et al , 2018; Zhu et al , 2018; Bhat et al , 2020)).…”
Section: An Overview Of Tunneling Nanotubesmentioning
confidence: 99%
“…Recent work has explored the mechanisms behind TNT formation in neuronal cells. Overexpression of Rab35, a small GTPase involved in membrane recycling, induces TNT formation while inhibition of TNTs occurs with the addition of a dominant negative mutant of Rab35 ( 35 ). ACAP2, a downstream effector of Rab35, was shown to positively regulate TNT formation using a similar approach ( 35 ).…”
Section: Signaling Formation Of Tntsmentioning
confidence: 99%
“…Overexpression of Rab35, a small GTPase involved in membrane recycling, induces TNT formation while inhibition of TNTs occurs with the addition of a dominant negative mutant of Rab35 ( 35 ). ACAP2, a downstream effector of Rab35, was shown to positively regulate TNT formation using a similar approach ( 35 ). ACAP2 does so through the inhibition of ARF6 which allows PI4P to recruit EHD1 ( 35 ).…”
Section: Signaling Formation Of Tntsmentioning
confidence: 99%
See 2 more Smart Citations