Rab37 mediates trafficking and membrane presentation of PD-1 to sustain T cell exhaustion in lung cancer
Wan-Ting Kuo,
I-Ying Kuo,
Hung-Chia Hsieh
et al.
Abstract:Background
Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor expressed on the surface of T cells. High expression of PD-1 leads to T-cell dysfunction in the tumor microenvironment (TME). However, the mechanism of intracellular trafficking and plasma membrane presentation of PD-1 remains unclear.
Methods
Multiple databases of lung cancer patients were integratively analyzed to screen Rab proteins and potential immune-related si… Show more
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