Rabies: Presentation, case management and therapy

Hemachudha, Pasin; Hemachudha, Thiravat

doi:10.1016/j.jns.2021.117413

Cited by 11 publications

(17 citation statements)

References 62 publications

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“…[5] At present, all forms of rabies treatment recommendation are essentially palliative because there are no evidence based medicine treatment. [6] e present rabies infection treatment aims to decrease agitation, reducing the suffering with sedatives, analgesics, and antipsychotics.…”

Section: Discussionmentioning

confidence: 99%

Rabies infection recognized as a psychosis: A misleading psychiatric presentation

Ferdaouss¹,

Boujraf

Ismail³

et al. 2023

JNRP

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Section: Discussionmentioning

confidence: 99%

Rabies infection recognized as a psychosis: A misleading psychiatric presentation

Ferdaouss¹,

Boujraf

Ismail³

et al. 2023

JNRP

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“…With such a low success rate, the treatment has been abandoned by many doctors. WHO also does not recommend coma-inducing therapy ( 11 ). There is also evidence that the therapy fails to clear rabies from the brain.…”

Section: Discussionmentioning

confidence: 99%

Case report: Blood purification effectively relieves multiple system failure in patient with rabies

Kuang

Luo²,

Chen³

et al. 2022

Front. Public Health

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Rabies is an infectious disease of animal origin with a high mortality rate. In the early stages of rabies, the rabies virus (RABV) is usually undetectable in saliva and cerebrospinal fluid (CSF). In addition, there are still no effective drugs and treatments. Here, we present a case in which blood purification alleviated multisystem failures. The patient was a 45-year-old woman who presented with the fear of water and wind, restlessness, and hyperactivity. RABV was detected in her saliva by high-throughput sequencing Next Generation Sequencing (NGS) and polymerase chain reaction (PCR). Based on typical clinical symptoms and the result of NGS and PCR, the patient was diagnosed as a confirmed case of rabies. Hemodialysis combined with antiviral therapy and intensive care unit (ICU) treatment can effectively relieve circulatory failure, respiratory failure, and renal failure. Finally, she died of brain death on the 34th day of admission. The case report showed that blood purification was positive for rabies-induced organ failure. Blood purification combined with antiviral therapy can prolong the lives of patients with rabies to some extent.

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“…Since the spatial distribution of reservoir hosts can be altered by climate change and the accompanying rise in temperature, anticipating such shifts is essential for rabies control and eradication strategies [ 20 ]. As the ambient temperature goes up, so does the number of reported cases of rabies [ 21 ]. Because more animals will be active and able to track greater distances in warmer weather, rabies is more likely to spread [ 22 ].…”

Section: Ecological Factorsmentioning

confidence: 99%

Ecological and Socioeconomic Factors in the Occurrence of Rabies: A Forgotten Scenario

Subedi

Chandran

Subedi

et al. 2022

Infectious Disease Reports

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In many third world countries, where rabies is endemic in dog populations, humans continue to be at risk of contracting the disease. Vaccination is the most effective form of prophylaxis for people, yet it often fails to adequately protect dogs. The most major implications are the costs of post-exposure prophylaxis (PEP) after an exposure occurs and the loss of human life and productivity due to early mortality from rabies (about 60,000 deaths annually). The largest rabies death tolls can be found in the world’s poorest regions, where rabies vaccinations for domestic dogs are uncommon and PEP is scarce. Mass vaccination of dogs, neutering programs, patient PEP, strengthening laboratory and human resources, education and awareness, and animal and human rabies surveillance are all common methods used to prevent, control, and ultimately eradicate dog-mediated human rabies. Current rabies control initiatives, however, pay little attention to the role that ecological and socioeconomic variables play in the disease’s occurrence and spread. To help better inform rabies control strategies, we address in this work the ways in which ecological and socioeconomic factors affect the occurrence and spread of rabies.

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Rabies: Presentation, case management and therapy

Cited by 11 publications

References 62 publications

Rabies infection recognized as a psychosis: A misleading psychiatric presentation

Rabies infection recognized as a psychosis: A misleading psychiatric presentation

Case report: Blood purification effectively relieves multiple system failure in patient with rabies

Ecological and Socioeconomic Factors in the Occurrence of Rabies: A Forgotten Scenario

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