Racemic drug resolution: a comprehensive guide

Abstract

The human body is amazingly chirally selective, and consequently enantiopure drugs are essential for treating disease. Nowadays, market approval of enantiopure drugs has increased exponentially whereas it has tremendously decreased for racemic and achiral drugs.

Widening the Scope of “Inherently Chiral” Electrodes: Enantiodiscrimination of Chiral Electroactive Probes with Planar Stereogenicity

“…Therein, chiral chromatography techniques are commonly applied, particularly for routine determinations. [1] However, the electrochemical approach to direct enantiomer discrimination is increasingly emerging as very interesting, and more and more effective strategies and selectors are being considered. Particularly attractive are voltammetric measurements based on electron transfers at suitable enantiopure chiral interphases resulting in different potentials for the enantiomers of chiral probes.…”

Preparation of Enantiomerically Enriched P-Stereogenic Dialkyl-Arylphosphine Oxides via Coordination Mediated Optical Resolution

“…Classical resolutions are generally robust, bench-stable processes that can be scaled up. Moreover, resolving agents can be recycled, and the undesired enantiomer can be racemized and reused [47,48]. One group of resolution methods developed for chiral phosphine oxides applies classical resolving agents having either acidic or basic character.…”

An Exploration of Induced Supramolecular Chirality Through Association of Chiral Ammonium Ions and Tartrates with the Achiral Host Cucurbit[7]uril

“…[1][2][3][4] These limitations then determine the choices available for the most efficient route to a product, whether it is through asymmetric synthesis, the separation of enantiomeric mixtures or a combination of both. [1][2][3][4] These limitations then determine the choices available for the most efficient route to a product, whether it is through asymmetric synthesis, the separation of enantiomeric mixtures or a combination of both.…”

“…Important industrial processes for the synthesis of ingredients and products with chiral activity are restricted by cost and physical limitations imposed by the requirement for large scale. [1][2][3][4] These limitations then determine the choices available for the most efficient route to a product, whether it is through asymmetric synthesis, the separation of enantiomeric mixtures or a combination of both. One of the most cost effective approaches to the efficient synthesis of pure chiral commercial products is the utilization of synthetic procedures involving enantio-pure reagents or precursors at a critical step during synthesis.…”