Racial Differences in the Association of Endometriosis and Uterine Leiomyomas With the Risk of Ovarian Cancer

Harris, Holly R.; Peres, Lauren C.; Johnson, Courtney E.; Guertin, Kristin A.; Beeghly, Alicia; Bandera, Elisa V.; Bethea, Traci N.; Joslin, Charlotte E.; Wu, Anna H.; Moorman, Patricia G.; Ochs‐Balcom, Heather M.; Petrick, Jessica L.; Setiawan, Veronica Wendy; Rosenberg, Lynn; Schildkraut, Joellen M.; Myers, Evan R.

doi:10.1097/aog.0000000000005191

Cited by 11 publications

(7 citation statements)

References 38 publications

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“…rs143094271-G has been associated with a decreased risk of having uterine fibroids (OR=0.70) 88 . Women with uterine fibroids have been found to be at increased risk of developing OC 89 . However, despite rs143094271-G being associated with women being less likely to have uterine fibroids, we found that rs143094271-G yielded an increased risk of developing HGSOC.…”

Section: Discussionmentioning

confidence: 99%

Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk

Barnes,

Tyrer,

Dennis

et al. 2024

Preprint

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BackgroundNineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We used data from the Ovarian Cancer Association Consortium (OCAC), Consortium of Investigators of Modifiers ofBRCA1/BRCA2(CIMBA), UK Biobank (UKBB), and FinnGen to identify novel HGSOC susceptibility loci and develop polygenic scores (PGS).MethodsWe analyzed >22 million variants for 398,238 women. Associations were assessed separately by consortium and meta-analysed. OCAC and CIMBA data were used to develop PGS which were trained on FinnGen data and validated in UKBB and BioBank JapanResultsEight novel variants were associated with HGSOC risk. An interesting discovery biologically was finding thatTP533’-UTR SNP rs78378222 was associated with HGSOC (per T allele relative risk (RR)=1.44, 95%CI:1.28-1.62, P=1.76×10-9). The optimal PGS included 64,518 variants and was associated with an odds ratio of 1.46 (95%CI:1.37-1.54) per standard deviation in the UKBB validation (AUROC curve=0.61, 95%CI:0.59-0.62).ConclusionsThis study represents the largest GWAS for HGSOC to date. The results highlight that improvements in imputation reference panels and increased sample sizes can identify HGSOC associated variants that previously went undetected, resulting in improved PGS. The use of updated PGS in cancer risk prediction algorithms will then improve personalized risk prediction for HGSOC.

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Section: Discussionmentioning

confidence: 99%

Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk

Barnes,

Tyrer,

Dennis

et al. 2024

Preprint

Self Cite

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“…The relationship between hysterectomy and ovarian cancer is intricate. Previous studies suggest that hysterectomy may impede retrograde menstrual flow and the transfer of carcinogenic substances ( 60 ), thereby reducing the risk of ovarian cancer. Khoja et al.…”

Section: Eaoc Risk Factorsmentioning

confidence: 99%

Research progress in endometriosis-associated ovarian cancer

Tang,

Bian

2024

Front. Oncol.

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Endometriosis-associated ovarian cancer (EAOC) is a unique subtype of ovarian malignant tumor originating from endometriosis (EMS) malignant transformation, which has gradually become one of the hot topics in clinical and basic research in recent years. According to clinicopathological and epidemiological findings, precancerous lesions of ovarian clear cell carcinoma (OCCC) and ovarian endometrioid carcinoma (OEC) are considered as EMS. Given the large number of patients with endometriosis and its long time window for malignant transformation, sufficient attention should be paid to EAOC. At present, the pathogenesis of EAOC has not been clarified, no reliable biomarkers have been found in the diagnosis, and there is still a lack of basis and targets for stratified management and precise treatment in the treatment. At the same time, due to the long medical history of patients, the fast growth rate of cancer cells, and the possibility of eliminating the earliest endometriosis-associated ovarian cancer, it is difficult to find the corresponding histological evidence. As a result, few patients are finally diagnosed with EAOC, which increases the difficulty of in-depth study of EAOC. This article reviews the epidemiology, pathogenesis, risk factors, clinical diagnosis, new treatment strategies and prognosis of endometriosis-associated ovarian cancer, and prospects the future direction of basic research and clinical transformation, in order to achieve stratified management and personalized treatment of ovarian cancer patients.

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“…58 Other studies found endometriosis and uterine fibroids, but not early menarche, to be relevant risks for Black patients with EOC. 59,60 Enriched data sets such as the Ovarian Cancer in Women of African Ancestry from diverse populations are critical to improve studies of disparities.…”

Section: Disparities In Risk Reduction and Prevention In Ovarian Cancermentioning

confidence: 99%

“…One such effort studied 10 EOC risk factors and found population risk attributably higher for Black women for all risk factors collectively including family history of breast cancer, body mass index, OCP use, aspirin, and body powder 58 . Other studies found endometriosis and uterine fibroids, but not early menarche, to be relevant risks for Black patients with EOC 59,60 . Enriched data sets such as the Ovarian Cancer in Women of African Ancestry from diverse populations are critical to improve studies of disparities.…”

Section: Ovarian Cancermentioning

confidence: 99%

Disparities in Gynecologic Cancers

Lee,

Tiro,

Odunsi

2023

Cancer J

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Gynecologic cancer disparities have different trends by cancer type and by sociodemographic/economic factors. We highlight disparities in the United States arising due to poor delivery of cancer care across the continuum from primary prevention, detection, and diagnosis through treatment and identify opportunities to eliminate/reduce disparities to achieve cancer health equity. Our review documents the persistent racial and ethnic disparities in cervical, ovarian, and uterine cancer outcomes, with Black patients experiencing the worst outcomes, and notes literature investigating social determinants of health, particularly access to care. Although timely delivery of screening and diagnostic evaluation is of paramount importance for cervical cancer, efforts for ovarian and uterine cancer need to focus on timely recognition of symptoms, diagnostic evaluation, and delivery of guideline-concordant cancer treatment, including tumor biomarker and somatic/germline genetic testing.

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Racial Differences in the Association of Endometriosis and Uterine Leiomyomas With the Risk of Ovarian Cancer

Abstract: Black and White participants with endometriosis had a higher risk of ovarian cancer; hysterectomy modified this association only among White participants.

Cited by 11 publications

References 38 publications

Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk

Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk

Research progress in endometriosis-associated ovarian cancer

Disparities in Gynecologic Cancers

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