Racial disparities in mortality among patients with prurigo nodularis: A multi-center cohort study

Sutaria, Nishadh; Adawi, Waleed; Brown, Isabelle; Parthasarathy, V.; Roh, Youkyung S.; Choi, Justin; Bordeaux, Zachary A.; Trinh, Pavin; Le, Thomas K.; Deng, Junwen; Semenov, Yevgeniy R.; Kwatra, Shawn G.

doi:10.1016/j.jaad.2021.09.028

Cited by 12 publications

(7 citation statements)

References 5 publications

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“…As PN was shown in other studies 9 , 10 , 11 to be more frequent in Black and African American individuals, we conducted an ethnicity-specific analysis to identify RD between ethnic backgrounds. To this end, sub-groups with control patients or patients with PN with skin of colour (n = 13,612 for both groups after propensity matching) and white control patients or patients with PN (n = 42,553) were identified.…”

Section: Resultsmentioning

confidence: 99%

“… 5 , 6 , 7 , 8 Overall prevalence is estimated at 72 per 100,000 individuals with a female predominance and higher frequencies in Black and African American individuals. 9 , 10 , 11 PN is associated with a variety of systemic disorders, including chronic kidney and cardiovascular diseases, HIV, chronic hepatitis C infection, chronic obstructive pulmonary disease, but also chronic inflammatory skin diseases like atopic dermatitis, psychiatric comorbidities and neoplasms. 11 , 12 , 13 , 14 , 15 , 16…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Increased cardiovascular risks and mortality in prurigo nodularis: a global cohort study

Olbrich,

Kridin,

Hernández

et al. 2024

eBioMedicine

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Increased cardiovascular risks and mortality in prurigo nodularis: a global cohort study

Olbrich,

Kridin,

Hernández

et al. 2024

eBioMedicine

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“…Due to potential variations in the coding of PN in medical claims, this statistic could be a conservative approximation. Recent research indicates that PN impacts an estimated 36.7 to 148.3 individuals per 100,000 in the US [14,15], and the highest prevalence is observed among patients of color [16][17][18]. In European countries, its prevalence varies, ranging from 8 to 200 cases per 100,000 people [1,16], and the annual incidence in Germany is reportedly 0.02% [19].…”

Section: Epidemiologymentioning

confidence: 99%

Prurigo Nodularis: Pathogenesis and the Horizon of Potential Therapeutics

Yook,

Lee

2024

IJMS

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Chronic pruritus that lasts for over 6 weeks can present in various forms, like papules, nodules, and plaque types, with prurigo nodularis (PN) being the most prevalent. The pathogenesis of PN involves the dysregulation of immune cell–neural circuits and is associated with peripheral neuropathies, possibly due to chronic scratching. PN is a persistent and challenging condition, involving complex interactions among the skin, immune system, and nervous system. Lesional skin in PN exhibits the infiltration of diverse immune cells like T cells, eosinophils, macrophages, and mast cells, leading to the release of inflammatory cytokines and itch-inducing substances. Activated sensory nerve fibers aggravate pruritus by releasing neurotransmitters, perpetuating a vicious cycle of itching and scratching. Traditional treatments often fail, but recent advancements in understanding the inflammatory and itch transmission mechanisms of PN have paved the way for innovative therapeutic approaches, which are explored in this review.

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“…30 Higher frequency and higher severity were shown in African Americans by comparison with other parts of the US population. 31 There is obviously no relationship with Fitzpatrick phototypes nor skin pigmentation. 32…”

Section: Epidemiologymentioning

confidence: 99%

Chronic prurigo

Miséry

2022

British Journal of Dermatology

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Chronic prurigo is a distinct disease defined by the presence of chronic pruritus for at least 6 weeks, a history and/or signs of repeated scratching, and multiple localized or generalized pruritic skin lesions (whitish or pinkish papules, nodules and/or plaques). Although chronic prurigo is frequently named prurigo nodularis, the nodular type of chronic prurigo is only the main clinical aspect of chronic prurigo. Chronic prurigo occurs due to neural sensitization to pruritus and the development of a vicious pruritus-scratching cycle. Chronic prurigo can be of allergological, dermatological, systemic, neurological, psychiatric/psychosomatic, mixed or undetermined origin. The prevalence is still debated. The burden is high. Current treatments often remained disappointing. Fortunately, recent research results on the pathophysiology of pruritus evidenced neuroimmune interactions and allow new therapeutic perspectives. Among them, antagonists of T-helper 2 cytokines, j-opioids and Janus kinase inhibitors may be promising.a Definition of pruriginous lesion: excoriated, scaling and/or crusted papules and/or nodules and/or plaques, often with a whitish or pink centre and hyperpigmented border.

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Racial disparities in mortality among patients with prurigo nodularis: A multi-center cohort study

Cited by 12 publications

References 5 publications

Increased cardiovascular risks and mortality in prurigo nodularis: a global cohort study

Increased cardiovascular risks and mortality in prurigo nodularis: a global cohort study

Prurigo Nodularis: Pathogenesis and the Horizon of Potential Therapeutics

Chronic prurigo

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