2019
DOI: 10.1101/811141
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Rad53 controls DNA unwinding after helicase-polymerase uncoupling at DNA replication forks

Abstract: The coordination of DNA unwinding and synthesis at replication forks promotes efficient and faithful replication of chromosomal DNA. Using the reconstituted budding yeast DNA replication system, we demonstrate that Pol e variants harboring catalytic point mutations in the Pol2 polymerase domain, contrary to Pol2 polymerase domain deletions, inhibit DNA synthesis at replication forks by displacing Pol d from PCNA/primer-template junctions, causing excessive DNA unwinding by the replicative DNA helicase, CMG, un… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 83 publications
(134 reference statements)
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?