Radamycin, a Novel Thiopeptide Produced by Streptomyces sp. RSP9. I. Taxonomy, Fermentation, Isolation and Biological Activities.

Holgado, Gloria Gonzalez; Rodriguez, Julian Castro; Hernandez, L.; Díaz, Margarita; Fernández-Ábalos, José Manuel; Trujillano, I; Santamaría, Ramón I.

doi:10.7164/antibiotics.55.383

Cited by 21 publications

(17 citation statements)

References 18 publications

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“…In liquid cultures, nostocyclamide was inhibitory to the growth of Anabaena at a concentration of 0.1 µM (1-week incubation in the light at 25 °C). Considerable toxicity was observed (LC 50 12 µM) in a freshwater rotifer (Brachionus calyciflorus) bioassay.…”

Section: General Mechanism Of Action Of Thiopeptide Antibioticsmentioning

confidence: 98%

“…collected in Sri Lanka [162]. Ambewelamide A exhibited potent in vitro cytotoxicity (murine leukemia P388, IC 50 16.2 pmol/ml) and it showed significant in vivo antineoplastic activity. Several scabrosin esters (213-217) from the lichen Xanthoparmelia scabrosa were found to exhibit potent cytotoxic activity against murine P815 mastocytomia cells and human breast MCF7 carcinoma cells, with IC 50 values of 0.5 µM and 1 nM, respectively [163,164].…”

Section: Epipolythiodioxopiperazinesmentioning

confidence: 99%

“…It is worth mentioning that cobalt or cobalamin must be present in the cultivation medium. The addition of these compounds strongly affects the ratio of individual antibiotics, due mainly to the fact that it increases methionine biosynthesis and the incorporation of methyl groups into the antibiotic [49][50][51]. Geninthiocin (67) was isolated from Streptomyces sp.…”

Section: Trisubstituted Pyridinesmentioning

confidence: 99%

“…It was also tested for the in vitro cytotoxicity by using human colon carcinoma and leukaemia cell cultures. The IC 50 values of cystothiazole A were 260-308 nmol/ml. Several related antibiotics from myxobacteria exhibit similar biological activities: myxothiazole from Myxococcus fulvus, and melithiazoles A and B from Melittangium lichenicolum.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacologically Active Sulfur-Containing Compounds

Řezanka¹,

Sobotka²,

Spížek³

et al. 2006

AIAMC

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In addition to sulfur-containing compounds that form essential and indispensable constituents of all living cells, there is a plethora of less wide-spread sulfur-containing compounds with much less common and often unexpected properties, chemical structures and biological activities. Some of these compounds have long been known as efficient antibiotics. This review surveys these less known compounds with two and more sulfur atoms in their molecule. In particular, it deals with natural heterocyclic compounds isolated, e.g., from bacteria, fungi, lichens, plants, and animals but also from unusual and exotic sources such as sea invertebrates (coelenterates, sponges, tunicates, sea worms), etc. Compounds such as calicheamicins, thiazole-related compounds and epipolythiodioxopiperazines may serve as examples. Because of their vast variety, individual compounds are grouped according to their chemical structure (only compounds whose chemical structure has been identified are included). These compounds affect a huge array of organisms from microorganisms to man, and the pharmacological activities they exert range from antiviral, antibacterial, antifungal, insecticidal or antiprotozoan effects to regulation of gene expression, cytoskeleton disruption, immunomodulation, plant growth stimulation or inhibition, pro-or antioxidant action, effects on selected enzymes, receptors and signal transduction pathways, etc. The activities are however often known only sketchily, and this paucity of data, and the fact that the activities were tested on a diverse spectrum of test organisms, cell lines, etc., is of necessity reflected in our survey. Two seemingly trivial but important points deserve attention: (a) compounds with widely different structures and from widely different sources have often very similar pharmacological effects; (b) a slight modification in the molecule may bring vast changes in the biological effects of the compound, in terms of quality, quantity and targeting. The purpose of the review was to show both the unique and common features of these compounds and to point out their potential usefulness for mankind.

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Section: General Mechanism Of Action Of Thiopeptide Antibioticsmentioning

confidence: 98%

Section: Epipolythiodioxopiperazinesmentioning

confidence: 99%

Section: Trisubstituted Pyridinesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pharmacologically Active Sulfur-Containing Compounds

Řezanka¹,

Sobotka²,

Spížek³

et al. 2006

AIAMC

View full text Add to dashboard Cite

show abstract

“…The new cyclic peptide antibiotic, radamycin (1) and the known thiopeptide methylsulfomycin I (2) have been isolated from the fermentation broth of a Streptomyces sp. RSP9.…”

mentioning

confidence: 99%