Radial flow system decouples reactions in automated synthesis of organic molecules

Automated stopped-flow library synthesis for rapid optimisation and machine learning directed experimentation

“…Recent advances in automation and flow chemistry have brought this concept closer. [21][22][23][24] In this, chemical reactions are performed under continuous flow, providing safe access to novel process windows (high temperatures and pressures, above solvents boiling point), 25 maximising mass and heat transfer per unit of volume, highly precise control and ease of automation. 26,27 These advantages have been exploited in several flow platforms developed for synthesis and manufacturing, involving process engineering and reaction optimisation, 5,28 which were also applied to synthesise compound libraries.…”

Device for automated screening of irradiation wavelength and intensity – investigation of the wavelength dependence of photoreactions with an arylazo sulfone in continuous flow

“…Automation plays an increasingly important role in laboratories, because it offers higher efficiency, improved reproducibility and safer handling of chemicals. [30][31][32] The novel device completes the equipment for systematic, time-efficient and programmable screening of photochemical reactions in continuous flow at defined irradiation wavelength, intensity and time.…”