Radiation damage in muscle cell membranes and regulation of cell metabolism

Portela, A.; González, J. C.; Stewart, Peter A.; Hines, Marion; Reddy, V. R.

doi:10.1016/s0014-4827(63)80015-4

Cited by 11 publications

(2 citation statements)

References 11 publications

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“…Many forms of irradiation appear to change the permeability of cells. Irradiations at high doses enhance cell permeability considerably (Portela et al 1963, Skou 1963, Srb and Hluchovsky 1963, van der Schueren and Phjisiol. Plant., 20,1967 Ronte 1958, Weijer 1963).…”

Section: Discussionmentioning

confidence: 99%

“…There is no doubt that nucleic acids and normal metabolic processes are increasingly inactivated as the dose increases. Considering the mode of injnries to the cell wall and membrane induced by irradiation (Heilbrunn and Mazia 1936, Portela et al 1963, Srb and Hluchovsky 1963, Weijer 1963, one can assume that the protective action of Ca against the death of pollen by irradiation (Table 2) occurred through a decrease in cell permeability and increased rigidity of the cell wall or membrane, due to an increased amount of available Ca surrounding the cell.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Calcium Ion and the Protective Action on Survival and Growth Inhihition of Pollen

Kwack¹,

Kim²

1967

Physiologia Plantarum

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Studies were condvicled on the protective action of Ca against growth inhibition and death of pollen from Crinum auaticum and Catharanthus TOSCUS. Ca ions not only promoted pollen germination and pollen tube growth, but also were antagonistic to pollen injuries induced by various chemical and physical treatments. Most of the chemicals used seemed to act as osmotic inhibitors, .f^mong the chemical agents tested, DNP inhibited pollen germination more strikingly with Ca than without it, whereas pollen tube growth was enhanced, .\nother metabolic inhibitor, low temperature, showed a similar effect on pollen germination. Insignificant or no protective action of Ca was observed when IAA, TIBA and coumarin, were applied.Large populations of pollen when grown in cultural media witbout Ca showed a partial protective action.The protective action of Ca in pollen growth against various inhibitors required other cations such as Mg and K ions. The promoting of pollen growth by Ca also required tbese otber cations.Tbe protective action of Ca is considered to be based on its binding in tbe pollen cell walls, particularly in the pectic regions. This gives rise to a decreased permeability and increased structural rigidity against tbe chemical and physical inhibitors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Calcium Ion and the Protective Action on Survival and Growth Inhihition of Pollen

Kwack¹,

Kim²

1967

Physiologia Plantarum

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Cellular Mechanisms of a Young-Hering Visual System

Svaetichin

Negishi

Fatehchand

2008

Novartis Foundation Symposia

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Akute Wirkungen von R�ntgenstrahlen auf Membranpotential und -widerstand von Schneckenneuronen

Günther

Hug

1974

Radiat Environ Biophys

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Acute X-irradiation of the metaeerebral giant neurones of Helix pomatia above t000 Ror 3.4 kR/min (dose or dose rate threshold) leads to a significant reduction of the membrane potential. After blocking the afferent excitatory synapses the radiation depolarizations are strongly decreased but not completely SUl~pressed. Long-time irradiation at high dose rates and after the blocking of afferent synapses produces a depolarization in two phases: an immediate quick depolarization of about 10 mV is followed by a mueh slower decrease of the membrane potential. Substitution of extracellular sodium by tris ions suppresses the quick depolarization phase. The input resistance of the cell shows a transient inerease at the begin of irradiation followed by a substantial decrease. These results are diseussed in view of the possible meehanisms of radiation-indueed permeability changes in excitable membranes.Zusammen]assung. Röntgenbestrahlung der Metacerebralzellen im Oberschlundganglion der Weinbergschnecke führt oberhalb von ca. t000 R bzw. 3,4 kR/min (Schwellendosis bzw. Schwellendosisleistung) zu einer deutlichen Abnahme des }lembranpotentials. Die Bestrahlungsdepolarisationen werden bei :Blockierung der afferenten erregenden Synapsen stark vermindert, jedoch nicht völlig unterdrückt. Bei längerer :Bestrahlung mit hohen Dosisleistungen und nach Ausschaltung der synaptischen Einflüsse verlaufen die :Bestrahlungsdepolarisationen in zwei Phasen ab: eine schnelle Anfangsdepolarisation um ca. t0 mV wird von einer viel langsameren Abnahme des Membranpotentials gefolgt. Nach Austauschen der extrazellulären Na-Ionen durch Tris-Ionen tritt bei Bestrahlung nur noch die langsame Depolarisation auf. Der Membranwidelstand wird bei :Beginn der :Bestrahlung zungehst größer, um dann deutlich abzunehmen. Die :Befunde werden in Hinblick auf die Meehanismen der Strahlenwirkung auf die Permeabilitgtseigenschaften erregbarer Membranen diskutiert. Einleitung Die bisherigen Untersuchungen über die Wirkung von Röntgenstrahlen auf die elektrischen Eigenschaften von Zellmembranen haben meist eine Abnahme des ]~uhepotentials und des ~embranwiderstandes ergeben. Woodbury (i958) und Portela et al. (i960) fanden diese Effekte in Froschmuskelfasern erst nach Dosen von 50 000 1~ bei Dosisleistungen von ~ 500 R/min. In Anschluß an Arbeiten über strahleninduzierte Bewegungen bei Mimosen und anderen sensitiven Pflanzen (I-Iug u. Miltenburger, 1962; gug, ~iltenburger u. Esch, i964) zeigten Esch, Miltenburger u. ttug i964 an der Algenzelle Nitella bei Verwendung höherer Dosisleistungen (über 7 kl,/min), daß die Bestrahlungsdepolarisation sofort mit Beginn der Bestrahlung eintritt und innerhalb gewisser Grenzen reversibel ist. Andere Autoren haben diese Befunde bestätigt und eine gleichzeitige Abnahme 12 ]~ad. and Environm, Biophys., Vol. 11

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Radiation damage in muscle cell membranes and regulation of cell metabolism

Cited by 11 publications

References 11 publications

Effects of Calcium Ion and the Protective Action on Survival and Growth Inhihition of Pollen

Effects of Calcium Ion and the Protective Action on Survival and Growth Inhihition of Pollen

Cellular Mechanisms of a Young-Hering Visual System

Akute Wirkungen von R�ntgenstrahlen auf Membranpotential und -widerstand von Schneckenneuronen

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