Radiation dose reduction in paediatric coronary computed tomography: assessment of effective dose and image quality

Geryes, Bouchra Habib; Calmon, Raphaël; Khraiche, Diala; Boddaert, Nathalie; Bonnet, Damien; Raimondi, Francesca

doi:10.1007/s00330-015-4032-5

Cited by 16 publications

(6 citation statements)

References 40 publications

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“…Other quantities are used to express the radiation dose in medical imaging with ionising radiation including the effective dose [ 15 , 16 , 17 ]. Furthermore, there are different conversion factors for the calculation of the effective dose from the DLP for different age groups, and moreover, these factors differ among different studies and recommendations [ 3 , 13 , 18 , 19 , 20 ]. Therefore, because of the age and weight heterogeneity of our group of patients, we did not calculate the effective dose from the DLP.…”

Section: Methodsmentioning

confidence: 99%

Clinical Question Influence on Radiation Dose of Cardiac CT Scan in Children

et al. 2022

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Background: To assess the impact of different clinical questions on radiation doses acquired during cardiac computed tomography in children. Methods: A total of 116 children who underwent cardiac CT on a third-generation dual-source CT scanner were included. The clinical questions were divided into three main categories: the extent of scanning in the z-axis, coronary artery assessment and cardiac function assessment. Radiation dose values represented as a dose-length product (DLP) in mGy*cm were recorded from the CT scanner protocols. Results: There were significantly higher doses in cases with cardiac function assessment (median DLP 348 versus 59 mGy*cm, p < 0.01) and in cases with coronary artery assessment (median DLP 133 versus 71 mGy*cm, p < 0.01). Conclusion: The most important factor was the assessment of cardiac function, where the median radiation dose was 4.3× higher in patients with a request for cardiac function assessment. We strongly recommend that clinical requests for cardiac CT should be carefully considered in the paediatric population.

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Section: Methodsmentioning

confidence: 99%

Clinical Question Influence on Radiation Dose of Cardiac CT Scan in Children

et al. 2022

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“…The copyright holder for this preprint this version posted May 11, 2023. ; https://doi.org/10.1101/2023.05.11.540418 doi: bioRxiv preprint with the procedures of the APHP data protection office (N° 20201112163629). Patient CT examinations were done using a Lightspeed VCT 64-slices, GE Healthcare (Coverage 4 cm of patient anatomy per rotation, gathering 64 slices at 0.625 mm) (Habib Geryes et al, 2016). During CT acquisitions, contrast (Iomeron® 300 mg/ml, 2mL/kg) was injected at a flow rate determined by body size and intravenous access size (1.5 ml/s up to 2 ml/s) followed by a saline flush using a power injector.…”

Section: Patient Recruitment and Cardiac Imagingmentioning

confidence: 99%

Torsion of the heart tube by shortage of progenitor cells : identification ofGreb1las a genetic determinant of criss-cross hearts in mice

Bernheim,

Borgel,

Garrec

et al. 2023

Preprint

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Despite their burden and impact, most congenital defects remain poorly understood by lack of knowledge of the embryological mechanisms. Here, we identify Greb1l mutants as the first mouse model of criss-cross heart. Based on 3D quantifications of shape changes, we demonstrate that torsion of the atrioventricular canal occurs together with supero-inferior ventricles at E10.5, after heart looping. Mutants phenocopy specific features of partial deficiency in retinoic acid signalling, suggesting that GREB1L is a novel modulator of this signalling. Spatio-temporal gene mapping and cross-correlated transcriptomic analyses further reveal the role of Greb1l in maintaining a pool of precursor cells during heart tube elongation, by controlling ribosome biogenesis and cell differentiation. Growth arrest and malposition of the outflow tract are predictive of abnormal tube remodelling in mutants. Our work on a rare cardiac malformation opens novel perspectives on the origin of a broader spectrum of congenital defects associated with GREB1L in humans.

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“…However, technological advances now allow for prospective acquisitions with good image quality while still achieving low radiation doses (54, 55). With prospective ECG triggering, images are obtained at the set time point or window (millisecond or percentage of the R-R interval), often during mid systole or mid diastole when the heart is assumed to have the least motion.…”

Section: Ct Image Acquisitionmentioning

confidence: 99%

Cardiovascular MRI and CT in congenital heart disease

et al. 2019

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Cardiac MRI and CT are increasingly used in the diagnosis and management of patients with congenital heart disease as an imaging adjunct to echocardiography. The benefits and limitations of both modalities are highlighted, with a focus on the anatomical, functional and haemodynamic information that can be gained from the different modalities. Deciding on the imaging modality of choice must also take into account patient factors such as age, compliance, the type of congenital heart disease, and previous procedures. Future developments in CT and MRI are also discussed.

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Radiation dose reduction in paediatric coronary computed tomography: assessment of effective dose and image quality

Abstract: • Using ASIR allows 25 % to 41 % reduction in the ED. • Prospective protocol is used up to 51 % of children after premedication. • Low dose is possible using ASIR and optimized prospective paediatric cCT.

Cited by 16 publications

References 40 publications

Clinical Question Influence on Radiation Dose of Cardiac CT Scan in Children

Clinical Question Influence on Radiation Dose of Cardiac CT Scan in Children

Torsion of the heart tube by shortage of progenitor cells : identification ofGreb1las a genetic determinant of criss-cross hearts in mice

Cardiovascular MRI and CT in congenital heart disease

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