Radiation Myelopathy

Pallis, C; LOUIS, SYDNEY; MORGAN, ROWLAND L.

doi:10.1093/brain/84.3.460

Cited by 141 publications

(41 citation statements)

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“…Medulla spinalis gibi yavaş prolifere olan dokularda geç etkiler çoğun-lukla kalıcı hasarlara neden olur. [2,3,[6][7][8] Yasui ve ark. RM'sini klinik spektruma göre dört kategoriye ayırmışlardır: a) Akut parapleji veya kuadripleji, b) Alt motor nöron bulguları, c) Akut geçici RM, d) Kronik progresif RM.…”

Section: Discussionunclassified

“…Medulla spinalis metastazı ve primer medulla spinalis lezyonlarının olmaması. [8] Hastamız C1-T1 vertabra korpusları arasına RT alması ve nörolojik defisitinin de olması nedeniyle ile bu üç kritere uymaktaydı.…”

Section: Discussionunclassified

“…Arkasından birçok makalelerde servikal spinal kordun tolerans dozu gündeme gelmiştir. [1,8] RT sonrası geç miyelopati gelişme riski, uygulanan total doz ve fraksiyon başına verilen doz ile ilişkili olmasına karşın tek etmen bu değildir. Günlük dozun 200 cGy olarak tutulması ve total 4500 cGy'in üzerindeki dozlardan kaçınılması RM'yi önleyici olabilir.…”

Section: Discussionunclassified

“…Kronik miyelopati çok ciddi ve geç bir komplikasyon olup, bundan dolayı spinal kord radyoterapide doz sınırlayıcı organdır. [4][5][6][7][8][9] Bu yazıda, nazofarenks kanserli hastada kemoradyoterapi sonrası gelişen radyasyon miyelopatisinin klinik özellikleri ve tedavisi tartışıldı. rildi.…”

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Radiation myelopathy: a case report

Cihan

2013

TJ Oncol

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Normal tissue injury may lead to severe late side effects after therapeutic use of irradiation. Radiation myelopathy (RM) is an uncommon complication of therapeutic irradiation whenever the spinal cord is included within the radiation treatment field. Several factors such as radiation dose, fractination, linear energy transfer, chemotherapy, modify its occurrence and severity. Herein, we report a 43-year-old male patient with nasopharyngeal cancer who developed RM after concomitant chemoradiotherapy and discussed the literature.

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Section: Discussionunclassified

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Radiation myelopathy: a case report

Cihan

2013

TJ Oncol

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“…In a paraplegic patient from malignant disease, and who has had radiotherapy the possibility of radiation myelopathy must always be kept in mind, if no other cause of the paraplegia is detected (Pallis 1961). To *Read at the Annual Scientific Meeting of the International Medical Society of Paraplegia, Athens, Greece, October, 1982. illustrate the problem that cord damage may obscure malignancy, and may also conceal symptoms of deformity, three examples are described:…”

Section: Introductionmentioning

confidence: 99%

Pathological conditions obscured by paraplegia

Pool

1984

Spinal Cord

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CNS late effects after ALL therapy in childhood. Part I: Neuroradiological findings in long-term survivors of childhood ALL—an evaluation of the interferences between morphology and neuropsychological performance

Hertzberg¹,

Huk

Ueberall³

et al. 1997

Med. Pediatr. Oncol.

105

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The effect of cranial irradiation on possible therapy‐induced morphological central nervous system (CNS) side effects of children cured from acute lymphoblastic leukemia (ALL) is controversially discussed. In a retrospective multicenter study, 118 former ALL patients in first continous remission were investigated using cranial computerised tomography (CCT) or magnetic resonance imaging (MRI) scans to evaluate CNS related impairments. Corresponding to the different kinds of CNS prophylaxis, the patient sample was divided: group A (n = 39) receiving intrathecal methotrexate (ITMTX) and systemical medium‐high‐dose methotrexate (SMHDMTX), group B (n = 41) cranial irradiated (in mean 16.8 Gy) and administering ITMTX and SMHDMTX, group C (n = 38) irradiated (in mean 17.1 Gy) and getting ITMTX. Pathologic scans showed atrophy, leukoencephalopathy, calcifications or grey matter changes. These findings were compared with the neuropsychological test results. Abnormal MRI or CCT scans were found in 61/118 patients (51.7%). Fifteen belonged to group A (38.5%), 23 to B (56.1%) and 23 to C (60.5%). Patients with definite CNS changes show reduced neuropsychological test results. The prevalence of brain alterations seems to appear twice increased after lengthening the post‐therapeutic interval in irradiated patients as in nonirradiated patients. Irradiated patients with an age younger than 2 years at diagnosis may show a lower prevalence for developing CNS alterations. CNS alterations are not sex‐related. Children treated with cranial irradiation in combination with SMHDMTX and/or ITMTX were at greater risk of developing morphological brain alterations than patients with chemotherapy alone. These alterations are partly correlated with reduced neuropsychological performances and seem to stay with a longer post‐therapeutic interval. Med. Pediatr. Oncol. 28: 387–400, 1997. © 1997 Wiley‐Liss, Inc.

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Radiation Myelopathy

Cited by 141 publications

References 0 publications

Radiation myelopathy: a case report

Radiation myelopathy: a case report

Pathological conditions obscured by paraplegia

CNS late effects after ALL therapy in childhood. Part I: Neuroradiological findings in long-term survivors of childhood ALL—an evaluation of the interferences between morphology and neuropsychological performance

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