Radiation Retinopathy 47 Years following Brachytherapy for Retinoblastoma

Bellerive, Claudine; Singh, Arun D.

doi:10.1159/000481312

Cited by 12 publications

(8 citation statements)

References 13 publications

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“…In our series, cataract was the most frequent complication, since it was present in all patients with a history of external radiotherapy, followed by non-proliferative maculopathy, vitreous hemorrhage and severe dry eye. The occurrence of radiation maculopathy has been reported in patients even after 40 years of treatment 24 , so it is possible that this complication appears in more patients in our series with a longer follow-up.…”

Section: Discussionmentioning

confidence: 80%

Ocular brachytherapy in the treatment of retinoblastoma. Experience in the Hospital Infantil de México

Ramírez-Patiño¹,

Engel²,

Lara-Molina³

et al. 2019

RMOE

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Objective: To describe results and complications of salvage eye treatment with brachytherapy in patients with diagnosis of bilateral retinoblastoma (Rb) and only one eye. Methods: Case series where we included all retinoblastoma patients treated with ocular brachytherapy with Iodine-125 at the Hospital Infantil de Mexico after failure of eye salvage with intravenous chemotherapy, focal transpupillary laser o transconjunctival cryotherapy and external beam radiotherapy. Results: We analyzed 7 patients, 2 females and 5 males. Two had hereditary retinoblastoma and all had bilateral disease. Mean follow-up after treatment was 5.35 years (range 3.3-11 years). Tumor control was achieved in five of seven patients; two patients undergone enucleation due to failure to achieve tumor control. One of the patients died because of secondary neoplasm. Conclusions: Ocular brachytherapy treatment in a tertiary care center offers possibilities of ocular preservation in patients with bilateral Rb and maximum oncological treatment.

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Section: Discussionmentioning

confidence: 80%

Ocular brachytherapy in the treatment of retinoblastoma. Experience in the Hospital Infantil de México

Ramírez-Patiño¹,

Engel²,

Lara-Molina³

et al. 2019

RMOE

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“… 8 Other reports described the treatment of radiation maculopathy secondary to retinoblastoma with focal laser photocoagulation and anti-VEGF injections. 1 , 9 …”

Section: Discussionmentioning

confidence: 99%

“…Radiation maculopathy (RM) is one of the causes of severe vision loss after radiation therapy to treat tumors or inflammation of the choroid, retina, orbit and paranasal sinuses. 1 The risk for development of radiation maculopathy is related to the total dose, radiation dose rate, comorbidity and the usage of radiation sensitizers. Radiation maculopathy has been reported to be a progressive disease characterized by cystoid macular edema (CME) and retina ischemia.…”

Section: Introductionmentioning

confidence: 99%

Short-term outcomes following treatment of recalcitrant cystoid macular edema secondary to radiation maculopathy using intravitreal brolucizumab

Corradetti

Corvi

Juhn

et al. 2020

American Journal of Ophthalmology Case Reports

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Purpose To assess the efficacy of intravitreal brolucizumab (Beovu®, Novartis Pharmaceuticals) in a case of recalcitrant cystoid macular edema associated with radiation maculopathy secondary to retinoblastoma which was suboptimally responsive to other intravitreal anti-vascular endothelial growth factor (VEGF) therapies. Observations A 42-year old patient with a history of radiation maculopathy complicated by cystoid macular edema after chemoreduction treatment and radiation therapy for retinoblastoma was treated with intravitreal brolucizumab. Best-corrected visual acuity and central macular thickness assessed by optical coherence tomography were used to assess the clinical outcomes. The treated eye was also assessed for evidence of intraocular inflammation following injection. Cystoid macular edema showed marked reduction and near resolution two weeks after injection and improvement in best-corrected visual acuity which was maintained for 2 months of follow-up. No ocular inflammatory reactions or other adverse events were reported. Conclusions and Importance This case of radiation maculopathy refractory to other intravitreal anti-VEGF treatments showed good treatment response to brolucizumab therapy.

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“…La braquiterapia es una modalidad de tratamiento del cáncer intraocular que se ha utilizado para el y ojo seco grave. La aparición de maculopatía por radiación se ha reportado en pacientes incluso después de 40 años de tratamiento 24 , por lo que es posible que esta complicación aparezca en más pacientes de nuestra serie con un seguimiento más prolongado. Los tumores que mejor respondieron al tratamiento fueron los que presentaban tumores de localización periférica, de menor tamaño (base y altura menor a 6 mm) y que no tuvieran siembras vítreas; siendo el caso 1, 2 y 3 los de mejor agudeza visual final, con 20/40, 20/80 y 20/30, respectivamente.…”

Section: Discussionunclassified

Braquiterapia ocular en el tratamiento del retinoblastoma. Experiencia en el Hospital Infantil de México

Ramírez-Patiño

Engel

Lara-Molina

et al. 2019

Revista Mexicana De Oftalmología

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Describir los resultados del tratamiento con braquiterapia ocular en ojos únicos en pacientes con retinoblastoma (Rb) bilateral, así como las complicaciones de su uso como tratamiento primario o secundario. Métodos: Serie de casos donde se identificaron todos los pacientes con Rb en el Hospital Infantil de México tratados con braquiterapia ocular con yodo-125 como salvamento ocular después del fallo en el control de la neoplasia mediante quimioterapia intravenosa, tratamiento focal con láser o crioterapia y radioterapia externa. Resultados: Se incluyeron un total de siete pacientes, dos pacientes eran del sexo femenino, y cinco, de sexo masculino. Dos pacientes tenían Rb hereditario y seis eran bilaterales. Tres de los ojos tratados con braquiterapia eran derechos. El seguimiento promedio de estos pacientes fue de 5.35 años (rango 3.3 a 11 años). El éxito del tratamiento se alcanzó en cinco de los siete pacientes. Dos pacientes fueron enucleados a pesar del tratamiento con braquiterapia por falla en el control de la neoplasia. Uno de los pacientes falleció por neoplasia secundaria. Conclusiones: El tratamiento con braquiterapia ocular en un hospital de tercer nivel ofrece posibilidades de preservación ocular en pacientes con Rb bilateral y tratamiento oncológico máximo.

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Radiation Retinopathy 47 Years following Brachytherapy for Retinoblastoma

Cited by 12 publications

References 13 publications

Ocular brachytherapy in the treatment of retinoblastoma. Experience in the Hospital Infantil de México

Ocular brachytherapy in the treatment of retinoblastoma. Experience in the Hospital Infantil de México

Short-term outcomes following treatment of recalcitrant cystoid macular edema secondary to radiation maculopathy using intravitreal brolucizumab

Braquiterapia ocular en el tratamiento del retinoblastoma. Experiencia en el Hospital Infantil de México

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