Radiation therapy for advanced and metastatic melanoma

Fogarty, Gerald B; Hong, Angela

doi:10.1002/jso.23509

Cited by 15 publications

(17 citation statements)

References 50 publications

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“…The latter is called the abscopal effect and has been described by several authors. [38][39][40][41] The suggested mechanism of action is immune-related, as changes in circulating immune cells and increases in antibodies against melanoma antigens were seen in these cases. In addition, some preclinical and clinical studies suggest that radiotherapy can enhance the therapeutic benefit of immunotherapy.…”

Section: Discussionmentioning

confidence: 88%

Retracted

Faut

Bisschop²,

Jalving³

et al. 2017

Annals of Surgery

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Section: Discussionmentioning

confidence: 88%

Retracted

Faut

Bisschop²,

Jalving³

et al. 2017

Annals of Surgery

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“…It is noteworthy, that CAP treatment was effective in tumor cells showing resistance to alkylating agents suggesting that the patients with an acquired glioma cell resistance to alkylating chemotherapy might benefit from the concomitant treatment with the CAP jets . To date, no resistance toward CAP treatment has been reported, supporting the notion that the direct use of CAP jet exposure as well as the use of the CAP‐activated media could be the promising tools in anti‐cancer therapy, especially as adjuvant treatments in a combination with the specific chemo‐ and radio‐ and even nano‐anti‐cancer therapies . Translation of in vitro results into clinical application is demanding and, therefore, further investigations of CAP effects on tumorigenic and non‐tumorigenic brain cells in vitro, as well as in vivo studies in eligible animal models need to be carried out.…”

Section: Cold Atmospheric Plasma and Cancer Treatmentmentioning

confidence: 89%

Anti‐Cancer Therapies of 21st Century: Novel Approach to Treat Human Cancers Using Cold Atmospheric Plasma

Ratovitski

Cheng

Yan

et al. 2014

Plasma Processes & Polymers

178

136

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Cold atmospheric plasma (CAP) has just recently been showing promising anti-cancer activities supported by ability to induce cell death via apoptosis and cell cycle arrest leading to tumor cell destruction in vitro, and in vivo. Several studies showed the ability of CAP-activated media to modulate the tumor cell environment a link between the generation of reactive oxygen species/reactive nitrogen species and cancer cell death following CAP treatment. Targeting cancer cells through ROS-mediated mechanisms has become an attractive strategy for effective and selective cancer treatment by exploiting the aberrant redox characteristics of cancer cells. These effects support the potential direct (CAP) and indirect (CAP-activated media) applications for adjuvant anti-cancer therapeutics, in a combination with the chemo-, radio-, and nano-therapies.

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“…Common indications for palliative RT include pain, mass effect, tumorrelated hemorrhage, and local irritation from skin or subcutaneous lesions (65). New RT techniques, such as SRS and SBRT, can achieve high probability of local control with very limited toxicity.…”

Section: Role Of Palliative Rt For Melanomasmentioning

confidence: 99%

Radiation Therapy for Melanoma

Shi

2017

Cutaneous Melanoma: Etiology and Therapy

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Although melanoma is a relative radioresistant tumor, radiation therapy (RT) remains a valid and effective treatment option for the management of melanoma. RT as a primary treatment is often offered in well-defined situations, such as medical inoperability, lentiginous melanoma, mucosal melanoma, and ocular melanoma. Adjuvant RT following lymphadenectomy in node-positive melanoma patients prevents local and regional recurrence; however, the role of adjuvant RT remains controversial and underutilized due to lack of overall survival benefit. On the other hand, RT is highly effective in providing symptom palliation for metastatic melanoma and is widely used. Advanced RT technologies such as stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT) can achieve excellent local control with minimum toxicities. They are commonly used in the management of brain, lung, spine, and liver metastases. Most recently, it is under active investigation on combining RT with new systemic options, such as targeted therapy, or immunotherapy. The advancements in the treatment of patients with melanoma highlight the importance of multidisciplinary management in this disease. Radiation therapy will continue to be one of the key therapeutic options.

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Radiation therapy for advanced and metastatic melanoma

Cited by 15 publications

References 50 publications

Retracted

Retracted

Anti‐Cancer Therapies of 21st Century: Novel Approach to Treat Human Cancers Using Cold Atmospheric Plasma

Radiation Therapy for Melanoma

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