Radiation therapy for angiosarcoma

Ward, Jon R.; Feigenberg, Steven J.; Mendenhall, Nancy P.; Marcus, Robert B.; Mendenhall, William M.

doi:10.1002/hed.10276

Cited by 71 publications

(68 citation statements)

References 22 publications

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“…Four patients also received chemotherapy, mainly with docetaxel. This treatment achieved a better local control rate (86% at 3 years) than previous studies ( Figure 3) (3,8,11,12,(18)(19)(20)(21)(22). The primary tumors of two patients who had presented with invasion of the skull and temporal muscle and received a total dose of 70 Gy in 35 fractions progressed after radiation therapy.…”

mentioning

confidence: 64%

“…Although previous studies have presented the outcomes of radiation therapy for angiosarcoma of the scalp, all of these series involved more than a few patients with tumors in other primary sites, including the face, body trunk, and extremities, and/or who had undergone surgery prior to radiation therapy (3,8,9,11,12,(21)(22)(23). Therefore, it is very difficult to determine the true efficacy of definitive radiation therapy for angiosarcoma of the scalp.…”

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confidence: 99%

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Radiation Therapy for Angiosarcoma of the Scalp: Total Scalp Irradiation and Local Irradiation

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2018

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confidence: 64%

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confidence: 99%

Radiation Therapy for Angiosarcoma of the Scalp: Total Scalp Irradiation and Local Irradiation

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2018

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“…Because both surgery and radiotherapy have been reported to be effective treatments for local therapy [6,7], we compared the LC rates according to the treatment modality and total radiation dose. Table 4 shows the LC status of radiotherapy with or without surgery according to total radiation dose.…”

Section: Recurrence Patternsmentioning

confidence: 99%

“…Since several reports have provided proof of a treatment efficacy of radiotherapy and surgery for patients with angiosarcoma of the scalp and face, this treatment combination has been recommended as an ideal treatment of these tumours [1,6,7,14]. Guadagnolo et al [14] analysed 70 patients with angiosarcoma of the scalp and face and found that combined surgery and radiotherapy was associated with improved OS, diseasespecific survival and LC compared with surgery or radiotherapy alone.…”

Section: Angiosarcoma Of the Scalp And Facementioning

confidence: 99%

“…Radiotherapy was generally performed in cases of widely spread and unresectable tumours, but the outcomes were also unsatisfactory [1,3]. Therefore, several authors advocated a combination of surgery and radiotherapy for these tumours [3,6,7]. Recently, chemotherapy and immunotherapy using recombinant interleukin-2 (rIL-2) have been studied as potential treatments [8,9].…”

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Treatment and prognosis of angiosarcoma of the scalp and face: a retrospective analysis of 48 patients

Ogawa

Takahashi²,

Asato³

et al. 2012

The British Journal of Radiology

104

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Objective: The objective of this study was to retrospectively analyse the treatment results of clinically localised angiosarcoma of the scalp and face. Methods: The records of 48 patients who were treated between 1987 and 2009 were reviewed. single modality or a combination of surgery, radiotherapy, chemotherapy and immunotherapy were administered. The median follow-up of all 48 patients was 13.7 months (range 2.5-105.9 months). Results: At the time of analysis, 45 of 48 patients (93.8%) had disease recurrences, and the lung was the most frequent site for recurrence (37 patients). In multivariate analysis, performance status (PS) and number of tumours were significant predictors of lungmetastasis-free (LMF) rate. For patients with multifocal tumours, chemotherapy use significantly decreased the LMF rate (p50.0072). The 2-year actuarial overall survival (OS), progression-free survival and local control rates in all 48 patients were 22.1%, 10.7% and 46.3%, respectively. In multivariate analysis, PS, number of tumours, surgery and radiotherapy were significant prognostic factors for OS. Patients treated with both surgery and radiotherapy (2-year OS: 45.8%) had a significantly more favourable OS (p,0.0001) than patients treated with either surgery or radiotherapy (2-year OS: 11.1%) and patients treated with neither surgery nor radiotherapy (2-year OS: 0%). Conclusions: Our results indicated that PS and number of tumours were significant predictors for developing lung metastases. Our results also indicated that PS, number of tumours, surgery use and radiotherapy use were independent prognostic factors for OS. Multimodal treatments including surgery and radiotherapy were effective in improving OS for patients with these tumours. Advances in knowledge: Multimodal treatments including surgery and radiotherapy are effective in improving overall survival for patients with angiosarcoma of the scalp and face.

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