Radiation therapy for localized prostate cancer

Abstract

Since 1965,401 patients with prostate cancer have received intensive local pelvic radiation therapy at the Virginia Mason Medical Center. Two hundred seventyseven of these patients were treated from 1965 through 1975, comprising the study group. Two hundred twenty-one of this series were in the Stage C category.The 36 Stage B cancers were either medically nonoperable, or advanced extent, or had high-grade histopathology. Ten patients each were in diffuse Stage A or Stage D groups, the latter receiving local palliative intensive treatment to the prostate area. The mean age of the patients was 67.6 years. The five year survival of the Stage C group was 57.7%. There was no apparent influence on the survival of irradiated Stage C patients who received estrogen therapy. Current treatment techniques employ 10 megavolt photon beam with whole pelvic nodal fields and bilateral arc rotational boost fields. The incidence of reactions and complications is presented.

Improved Survival in Patients with Locally Advanced Prostate Cancer Treated with Radiotherapy and Goserelin

“…Three controlled clinical trials have failed to demonstrate the value of prophylactic therapy with diethylstilbestrol, orchiectomy, or both in patients treated with external radiotherapy. [6][7][8] A study of 277 patients found no differences among those undergoing orchiectomy, radiotherapy, or combined treatment; orchiectomy, however, whether alone or combined with radiotherapy, significantly delayed metastases as compared with radiotherapy alone. 9 Goserelin is an agonist analogue of gonadotropinreleasing hormone that induces hypogonadism by reducing the secretion of gonadotropin and therefore testosterone.…”

Present Results of Neutron Therapy: The German experience

“…The 5-year local control rates for locally advanced prostatic cancer after high-dose photon therapy range between 54% and 68% (58)(59)(60)(61)(62)(63)(64). Results of neutron therapy has been studied at several centers in the United States and Europe.…”

Definitive Radiotherapy of Prostatic Cancer: The Norwegian Radium Hospital’s Experience (1976-1982)

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During the years 1976 to 1982 definitive curatively aimed radiotherapy to the primary tumor was given to 53 patients with prostatic cancer confined to the true pelvis (To,2;19; T3,24; Tq,8; No,18; N,,2; N,, 33); all patients were of the Mo-category. The pelvic lymph nodes received a total dose of 2 Gy X 25 by means of an anterior and posterior radiation field.

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