Radiation therapy for malignant brain tumors in infants less than 36 months old: Compliance and survival

Tao, Miriam; Turner, Joshua; Geyer, J. Russell; Donahue, Bernadine R.; Sposto, Richard; Ater, J; Axtell, Richard A.; Boyett, James M.; Breiger, David; Broxson, Emmett; Finlay, Jonathan L.; Goldwein, Joel W.; Heier, L.M.; Jennings, Mark T.; Johnson, D. M.; Mazewski, Claire; Miller, David S.; Neuberg, Ronnie W.; Packer, Roger J.; Puccetti, Diane

doi:10.1016/s0360-3016(00)80153-4

Cited by 2 publications

(1 citation statement)

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“…Most patients did not in fact receive radiotherapy and progression-free survival at 3 years was only 22% (AE 6%). Even the group of patients who had M0 disease and had undergone gross total resection did rather poorly, with only 30% of patients alive without any evidence of disease at a median follow-up of 72 months [29,30].…”

Section: Management Of Infants With Medulloblastomamentioning

confidence: 97%

Radiotherapy for medulloblastoma in children: A perspective on current international clinical research efforts

Freeman

Taylor²,

Kortmann

et al. 2002

Med. Pediatr. Oncol.

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Much progress has been made in the management of medulloblastoma in childhood as a consequence of the studies undertaken sequentially by these groups over the past two decades. It now seems clear that chemotherapy plays an important role for all patients. In patients with average risk disease, the use of chemotherapy has allowed a reduction in the dose of radiotherapy to the craniospinal axis and the combination of chemotherapy with radiotherapy appears to have brought about a significant improvement in disease-free and overall survival in this patient population. Patients with high-risk disease fare better now than in the past as a consequence of the routine use of aggressive chemotherapy and preliminary data suggest that the use of higher doses of radiation as in the POG studies is associated with a particularly favorable outcome. Accurate delivery of radiotherapy is essential for optimal results. The avail-ability of better tools at the treating centres and quality control as an integral part of cooperative studies are likely to bring about further improvements in outcome in the future.

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Section: Management Of Infants With Medulloblastomamentioning

confidence: 97%