2018
DOI: 10.1002/14651858.cd012605.pub2
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Radical multimodality therapy for malignant pleural mesothelioma

Abstract: The overall strength of the evidence gathered in this review is low and there is a lack of available evidence to support the use of radical multimodality therapy in routine clinical practice (particularly as one trial suggests greater harm). Given the added cost of multimodality treatment and the possible increase in risk of adverse effects, the lack of evidence of their effectiveness probably means that these interventions should currently be limited to clinical trials alone.

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Cited by 24 publications
(29 citation statements)
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“…Some germline mutations were also shown to predispose to mesothelioma (most commonly germline BAP1 mutations) which was associated with familial cases of mesothelioma . Other risk factors which were associated with mesothelioma development include exposure to irradiation, simian virus 40 (SV40), and erionite . It has to be stressed, however, that assessing and quantifying these factors are challenging and the literature is scarce.…”
Section: Discussionmentioning
confidence: 99%
“…Some germline mutations were also shown to predispose to mesothelioma (most commonly germline BAP1 mutations) which was associated with familial cases of mesothelioma . Other risk factors which were associated with mesothelioma development include exposure to irradiation, simian virus 40 (SV40), and erionite . It has to be stressed, however, that assessing and quantifying these factors are challenging and the literature is scarce.…”
Section: Discussionmentioning
confidence: 99%
“…So, the possible reason may be that the topics of the Chinese Cancer-CSR studies are not attractive and innovative enough. Egypt and Austria were the first time to publish the reviews in Cancer-CSR during the latest ten years, which focused more on the chemotherapy and multimodality therapy in cancer field (36,37) .…”
Section: General Informationmentioning
confidence: 99%
“…Depending on patient-and disease-related factors, treatment options may include surgery, chemotherapy, and radiation therapy (RT) and should be determined through a multidisciplinary management approach in experienced cancer centers. Despite advancements in treatment modalities, the prognosis of malignant mesothelioma remains poor with a median overall survival (OS) of 12--22 months [13,[17][18][19]. Given the constantly evolving treatment paradigm, we herein evaluate the published data on therapeutic options for MPM and propose a functional treatment algorithm.…”
Section: Introductionmentioning
confidence: 99%