Radioactive seed migration to the chest after transperineal interstitial prostate brachytherapy: extraprostatic seed placement correlates with migration

Eshleman, Jeffrey S.; Davis, Brian J.; Pisansky, Thomas M.; Wilson, Timothy O.; Haddock, Michael G.; King, Bernard F.; Darby, C. H.; LaJoie, Wayne N.; Oberg, Ann L.

doi:10.1016/j.ijrobp.2003.10.050

Cited by 80 publications

(59 citation statements)

References 32 publications

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“…Through the venous pathway, seeds may be gradually carried by the blood flow and migrate through the inferior vena cava, right chambers of the heart and into the pulmonary circulation [3].…”

Section: Seed Migration Through Blood Vesselmentioning

confidence: 99%

“…By way of the same pathway, seeds may enter the systemic circulation through right-to-left cardiac shunts [3]. In 1988, Hempel et al reported seed movement on a patient who underwent interstitial therapy for carcinoma of the anus and was later found to have metallic seeds on a chest X-ray [4].…”

Section: Introductionmentioning

confidence: 99%

“…Several clinicians have reported seed migration for about 30-40% of the patients that they have treated and the number of migrated seeds ranging from 1 to 10 per patient [16,17]. The occurrence and number of seed migration vary with the patient and treatment variables.…”

Section: Introductionmentioning

confidence: 99%

“…Two possible consequences of seed migration are inadequate dose coverage of the prostate [15] and potential effects of tissue irradiation at the site of migration. Although stranded seeds embedded in vicrylsutures migrate less (about 1%) than loose seeds (about 10%) [17]- [19], to accurately deliver the linked seeds is quite challenging. Therefore, the actual delivered dose may significantly deviate from the planned dose.…”

Section: Introductionmentioning

confidence: 99%

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Radioactive seed immobilization techniques for interstitial brachytherapy

et al. 2008

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Let us know how access to this document benefits you Methods: We first analyze the possible causes for seed movement, and propose three potential techniques for seed immobilization: (1) surgical glue, (2) laser coagulation and (3) diathermy coagulation. The feasibility of each method is explored. Experiments were carried out using fresh bovine livers to investigate the efficacy of seed immobilization using surgical glue. Results:Results have shown that the surgical glue can effectively immobilize the seeds.Evaluation of the radiation dose distribution revealed that the non-immobilized seed movement would change the planned isodose distribution considerably; while by using surgical glue method to immobilize the seeds, the changes were negligible.Conclusions: Prostate brachytherapy seed immobilization is necessary and three alternative mechanisms are promising for addressing this issue. Experiments for exploring the efficacy of the other two proposed methods are ongoing. Devices compatible with the brachytherapy procedure will be designed in future.

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Section: Seed Migration Through Blood Vesselmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Radioactive seed immobilization techniques for interstitial brachytherapy

et al. 2008

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“…However IDTP requires knowledge of location of each dropped seed in a prostate follow by fast re-planning. While a TRUS-based ITP system is a suitable method for prostate volumetric studies and needle guid-60 ance, some physicians remain skeptical of its seed position identification accuracy [14][15] [16] .…”

Section: Introductionmentioning

confidence: 99%

BrachyView: Proof‐of‐principle of a novel in‐body gamma camera for low dose‐rate prostate brachytherapy

et al. 2013

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. (2013). BrachyView: Proof-of-principle of a novel in-body gamma camera for low dose-rate prostate brachytherapy. Medical Physics, 40 (4), 041709-1-041709-9.Brachyview: proof-of-principle of a novel in-body gamma camera for low dose-rate prostate brachytherapy AbstractPurpose: The conformity of the achieved dose distribution to the treatment plan strongly correlates with the accuracy of seed implantation in a prostate brachytherapy treatment procedure. Incorrect seed placement leads to both short and long term complications, including urethral and rectal toxicity. The authors present BrachyView, a novel concept of a fast intraoperative treatment planning system, to provide real-time seed placement information based on in-body gamma camera data. BrachyView combines the high spatial resolution of a pixellated silicon detector (Medipix2) with the volumetric information acquired by a transrectal ultrasound (TRUS). The two systems will be embedded in the same probe so as to provide anatomically correct seed positions for intraoperative planning and postimplant dosimetry. Dosimetric calculations are based on the TG-43 method using the real position of the seeds. The purpose of this paper is to demonstrate the feasibility of BrachyView using the Medipix2 pixel detector and a pinhole collimator to reconstruct the real-time 3D position of low dose-rate brachytherapy seeds in a phantom. Methods: BrachyView incorporates three Medipix2 detectors coupled to a multipinhole collimator. Three-dimensionally triangulated seed positions from multiple planar images are used to determine the seed placement in a PMMA prostate phantom in real time. MATLAB codes were used to test the reconstruction method and to optimize the device geometry. Results: The results presented in this paper show a 3D position reconstruction accuracy of the seed in the range of 0.5-3 mm for a 10-60 mm seed-to-detector distance interval (Z direction), respectively. The BrachyView system also demonstrates a spatial resolution of 0.25 mm in the XY plane for sources at 10 mm distance from Medipix2 detector plane, comparable to the theoretical value calculated for an equivalent gamma camera arrangement. The authors successfully demonstrated the capability of BrachyView for real-time imaging (using a 3 s data acquisition time) of different brachytherapy seed configurations (with an activity of 0.05 U) throughout a 60 × 60 × 60 mm3 Perspex prostate phantom. Conclusions: The newly developed miniature gamma camera component of BrachyView, with its high spatial resolution and real time capability, allows accurate 3D localization of seeds in a prostate phantom. Combination of the gamma camera with TRUS in a single probe will complete the BrachyView system. © 2013 American Association of Physicists in Medicine. Keywords dose, low, camera, gamma, prostate, body, rate, novel, principle, proof, brachyview, brachytherapy Disciplines Engineering | Science and Technology Studies Publication DetailsPetasecca, M., Loo, K. J., Safavi-Naeini, M., Han, Z., Metcalfe, P. E., Meikle...

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A seed link connector protruding into the bladder formed a bladder stone

Aoyama,

Izumi,

Makino

et al. 2024

IJU Case Reports

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IntroductionLow‐dose‐rate brachytherapy is performed for localized prostate cancer. We report the first case of a bladder stone encompassing the seed migrated into the bladder in a patient treated with low‐dose‐rate brachytherapy.Case presentationA man was diagnosed with prostate cancer and underwent low‐dose‐rate brachytherapy. After 2 months, dysuria occurred, and ultrasonography revealed a needle‐shaped high‐intensity protruding from the prostate into the bladder. Cystoscopy examination found a seed link connector. With the possibility of natural dissolution of the seed link, careful observation was chosen. However, 16 months later, hematuria occurred, and an X‐ray revealed a bladder stone encompassing the seed. Compared with the X‐ray right after seeding, the seed located near the right bladder neck had fallen. The seed was removed by transurethral bladder lithotripsy.ConclusionSeeds should be carefully located within the prostate, otherwise a bladder stone may be formed encompassing the seed.

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Radioactive seed migration to the chest after transperineal interstitial prostate brachytherapy: extraprostatic seed placement correlates with migration

Cited by 80 publications

References 32 publications

Radioactive seed immobilization techniques for interstitial brachytherapy

Radioactive seed immobilization techniques for interstitial brachytherapy

BrachyView: Proof‐of‐principle of a novel in‐body gamma camera for low dose‐rate prostate brachytherapy

A seed link connector protruding into the bladder formed a bladder stone

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