Radioactive synthesis and biodistribution study of β-elemene–99mTc(CO)3 conjugates

β-elemene is a noncytotoxic Class II antitumor drug extracted from the traditional Chinese medicine Curcuma wenyujin Y. H. Chen et C. Ling. β-elemene exerts its effects by inhibiting cell proliferation, arresting the cell cycle, inducing cell apoptosis, exerting antiangiogenesis and antimetastasis effects, reversing multiple-drug resistance (MDR), and enhancing the immune system. Elemene injection and oral emulsion have been used to treat various tumors, including cancer of the lung, liver, brain, breast, ovary, gastric, prostate, and other tissues, for >20 years. The safety of both elemene injection and oral emulsion in the clinic has been discussed. Recently, the secondary development of β-elemene has attracted the attention of researchers and made great progress. On the one hand, studies have been carried out on liposome-based systems (including solid lipid nanoparticles [SLNs], nanostructured lipid carriers [NLCs], long-circulating liposomes, active targeting liposomes, and multidrug-loaded liposomes) and emulsion systems (including microemulsions, self-emulsion drug delivery systems [SEDDSs], and active targeting microemulsion) to solve the issues of poor solubility in water, low bioavailability, and severe phlebitis, as well as to improve antitumor efficacy. The pharmacokinetics of different drug delivery systems of β-elemene are also summarized. On the other hand, a number of highly active anticancer β-elemene derivatives have been obtained through modification of the structure of β-elemene. This review focuses on the two drug delivery systems and derivatives of β-elemene for cancer therapy.

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“…Sun et al 99 synthesized the β-elemene-99m Tc(CO) 3 (H 2 O) 3 + conjugate 9. The oil-water partition coefficient was reported as P=199.5±4.…”

Section: Radioactive Conjugatementioning

confidence: 99%

“…Micro-single-photon emission computed tomography (SPECT) images indicated that it had a significant accumulation in tumor regions after iv injection. 99…”

Section: Radioactive Conjugatementioning

confidence: 99%

Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy

Zhai

Zeng

et al. 2018

IJN

117

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Imaging the Laboratory Mouse in vivo

Lister¹,

Leopold²,

McConville³

2012

The Laboratory Mouse

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Structural Optimization and Modification Based on β-elemene

Jiang

Xie

2023

Elemene Antitumor Drugs

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Radioactive synthesis and biodistribution study of β-elemene–99mTc(CO)3 conjugates

Cited by 4 publications

References 18 publications

Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy

Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy

Imaging the Laboratory Mouse in vivo

Structural Optimization and Modification Based on β-elemene

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Radioactive synthesis and biodistribution study of β-elemene–99mTc(CO)3 conjugates

Cited by 4 publications

References 18 publications

Drug delivery systems for elemene, its main active ingredient &beta;-elemene, and its derivatives in cancer therapy

Drug delivery systems for elemene, its main active ingredient &beta;-elemene, and its derivatives in cancer therapy

Imaging the Laboratory Mouse in vivo

Structural Optimization and Modification Based on β-elemene

Contact Info

Product

Resources

About

Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy

Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy