Radiochemistry and Radiopharmacy

Hyperpolarization of amino acid precursors to neurotransmitters with parahydrogen induced polarization

“…Limited imaging techniques exist to follow the formation of neurotransmitters from their biological precursors to detect neurotransmitter production. 3 Hyperpolarization techniques such as dynamic nuclear polarization (DNP), optical pumping, and parahydrogen induced polarization (PHIP) have gained great interest in the past decade because they can provide sensitivity boosts by several orders of magnitude. PHIP is an economical and potentially high-throughput technique to yield hyperpolarized substrates, and it can be implemented either through a hydrogenation reaction using parahydrogen (p-H 2 ) or through reversible exchange (signal amplification by reversible exchange, SABRE).…”

124Iodine: A Longer-Life Positron Emitter Isotope—New Opportunities in Molecular Imaging

“…Prosthetic groups are bifunctional reagents; one allows for high yield radiohalogenation, and the other allows for conjugation to the biomolecule. This strategy became known as the “Bolton-Hunter method” [ 16 ].…”

99mTc-Technetium Shortage: Old Problems Asking for New Solutions

“…Thus, since the early 60s, hundreds of radiopharmaceuticals labeled with 99m Tc have been developed, and some have gained significant market success. However, the main reason for the special role of Technetium in SPECT is probably the cost effectiveness and the on-demand worldwide availability of the isotope through the 99 Mo/ 99m Tc generator systems [1].It all went smoothly until recently, when ''dark clouds'' appeared on the nuclear medicine global horizon. Since 2007, there were more than 11 periods of serious disruption of generator supplies, with the two most important in 2009 and 2010, involving the simultaneous (and extemporaneous!)…”

“…Thus, since the early 60s, hundreds of radiopharmaceuticals labeled with 99m Tc have been developed, and some have gained significant market success. However, the main reason for the special role of Technetium in SPECT is probably the cost effectiveness and the on-demand worldwide availability of the isotope through the 99 Mo/ 99m Tc generator systems [1].…”