Radiofrequency Ablation Combined with Hepatic Arterial Chemoembolization Using Degradable Starch Microsphere Mixed with Mitomycin C for the Treatment of Liver Metastasis from Colorectal Cancer: A Prospective Multicenter Study

Yamakado, Koichiro; Inaba, Y.; Sato, Yozo; Yasumoto, Taku; Hayashi, Shinya; Yamanaka, Takashi; Nobata, Koji; Takaki, Haruyuki; Nakatsuka, Atsuhiro

doi:10.1007/s00270-016-1547-3

Cited by 25 publications

(28 citation statements)

References 25 publications

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“…Concurrent capecitabine administration improved disease control but not survival[167], while adding FOLFOX and bevacizumab increased the conversion rate to resectability[168]. In non-surgical candidates, RFA combined with TACE attained local tumour control in 92% and OS at 2 years was 88.0%[169]. With better understanding of the properties of drug-eluting microspheres, results of DEB-TACE will improve and it will become a therapeutic option earlier in the course of disease e.g ., neoadjuvant therapy, first-line treatment for unresectable disease.…”

Section: Liver-directed Therapies In Unresectable Crlmmentioning

confidence: 99%

Colorectal liver metastases: An update on multidisciplinary approach

Chow¹,

Chok²

2019

WJH

190

148

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Liver metastasis is the commonest form of distant metastasis in colorectal cancer. Selection criteria for surgery and liver-directed therapies have recently been extended. However, resectability remains poorly defined. Tumour biology is increasingly recognized as an important prognostic factor; hence molecular profiling has a growing role in risk stratification and management planning. Surgical resection is the only treatment modality for curative intent. The most appropriate surgical approach is yet to be established. The primary cancer and the hepatic metastasis can be removed simultaneously or in a two-step approach; these two strategies have comparable long-term outcomes. For patients with a limited future liver remnant, portal vein embolization, combined ablation and resection, and associating liver partition and portal vein ligation for staged hepatectomy have been advocated, and each has their pros and cons. The role of neoadjuvant and adjuvant chemotherapy is still debated. Targeted biological agents and loco-regional therapies (thermal ablation, intra-arterial chemo- or radio-embolization, and stereotactic radiotherapy) further improve the already favourable results. The recent debate about offering liver transplantation to highly selected patients needs validation from large clinical trials. Evidence-based protocols are missing, and therefore optimal management of hepatic metastasis should be personalized and determined by a multi-disciplinary team.

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Section: Liver-directed Therapies In Unresectable Crlmmentioning

confidence: 99%

Colorectal liver metastases: An update on multidisciplinary approach

Chow¹,

Chok²

2019

WJH

190

148

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“…Currently, however, this technique is suitable mainly for tumors less than 4-5 cm in diameter and also results in incomplete ablation at tumor margins (2). To solve these problems, efforts have been made to combine thermal ablation with other treatment options, such as systemic and intra-arterial administration of therapeutics (3)(4)(5). In this issue of Radiology, White et al (6) introduced their work on development of an alternative approach by using biofunctionalized hybrid magnetic gold nanoparticles (HNPs) as catalysts for photothermal ablation of CRLM.…”

Section: Discussionmentioning

confidence: 99%

Science to Practice: Enhancing Photothermal Ablation of Colorectal Liver Metastases with Targeted Hybrid Nanoparticles

Yang

2017

Radiology

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Image-guided percutaneous thermal ablation has been one of the principal tools in management of unresectable liver malignancies, including colorectal liver metastases (CRLM) ( 1 ). Currently, however, this technique is suitable mainly for tumors less than 4-5 cm in diameter and also results in incomplete ablation at tumor margins ( 2 ). To solve these problems, efforts have been made to combine thermal ablation with other treatment options, such as systemic and intra-arterial administration of therapeutics ( 3 - 5 ). In this issue of Radiology, White et al ( 6 ) introduced their work on development of an alternative approach by using biofunctionalized hybrid magnetic gold nanoparticles (HNPs) as catalysts for photothermal ablation of CRLM. They found that (a) the targeted (anti-MG1) HNPs are noncytotoxic and have greater than 20% intratumoral accumulation and (b) systemic administration of anti-MG1 HNPs can enlarge a tumor's necrotic zone with photothermal ablation. The results of this study establish the proof of the concept that targeted HNPs can enhance the therapeutic effect of photothermal ablation, which presents an exciting strategy for complete removal of CRLM by integrating two rapidly advancing scientific fields-interventional radiology and nanotechnology.

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“…Синхронные метастазы в печень определяются у 15-27% пациентов с впервые диагностированным КРР [4]. У большинства из них уже имеются множествен ные билобарные метастазы в печень, которые являются главной причиной смерти в этой группе [5,6].…”

Section: ■ введениеunclassified

Prognosis of the combination therapy results in patients with synchronous metastases of colorectal cancer

Kozlov

Каганов

Moryatov

et al. 2019

Science and Innovations in Medicine

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Objectives - to optimize the indications for radiofrequency thermal ablation in patients with synchronous multiple metastases of colorectal cancer to the liver on the basis of prognostic treatment results. Material and methods. The study group included 78 patients with colorectal cancer with synchronous multiple bilobar liver metastases, who have underwent combined treatment in the period of 2007- 2015, such as cytoreductive surgery removing the primary intestinal tumor in combination with RFA of metastases in the liver, followed by chemotherapy. Results. A computer program for preoperative risk assessment of disease progression was developed and introduced in clinical practice. It is based on the results of the analysis of the factors, predicting the risk of relapse during the first year after cytoreductive surgery with RFA of synchronous multiple CRC liver metastases. Conclusion. The index of metastatic liver damage (the product of the sum of the diameters of metastatic liver lesions by their number), the mutational status of the KRAS gene, CEA values are significant factors in predicting the progression of the disease, which can optimize indications for radiofrequency thermal ablation in the treatment of patients with stage IV CRC with synchronous metastases to the liver.

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Radiofrequency Ablation Combined with Hepatic Arterial Chemoembolization Using Degradable Starch Microsphere Mixed with Mitomycin C for the Treatment of Liver Metastasis from Colorectal Cancer: A Prospective Multicenter Study

Abstract: This combination therapy is safe, exhibiting strong anticancer effects on colorectal liver metastasis, which might contribute to patient survival.

Cited by 25 publications

References 25 publications

Colorectal liver metastases: An update on multidisciplinary approach

Colorectal liver metastases: An update on multidisciplinary approach

Science to Practice: Enhancing Photothermal Ablation of Colorectal Liver Metastases with Targeted Hybrid Nanoparticles

Prognosis of the combination therapy results in patients with synchronous metastases of colorectal cancer

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