2017
DOI: 10.1016/j.jacep.2017.03.006
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Radiofrequency Ablation Using an Open Irrigated Electrode Cooled With Half-Normal Saline

Abstract: By decreasing ionic concentration and charge density in RFA using HNS instead of NS irrigant, larger ablation lesions can be created and are similar in size to lesions created using bipolar ablation. This may be a useful ablation strategy for deep myocardial circuits refractory to standard ablation. Further studies are needed to evaluate this novel RFA strategy.

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Cited by 102 publications
(86 citation statements)
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“…This technique was designed to induce tumor destruction by delivering a high‐frequency alternating current through an active needle‐electrode introduced into the neoplastic tissue . The resultant movement generated frictional heating which leads to cell death by means of coagulative necrosis . Therefore, heat deposition in tumor tissue is an important factor affecting efficacy of RFA treatment .…”
Section: Discussionmentioning
confidence: 99%
“…This technique was designed to induce tumor destruction by delivering a high‐frequency alternating current through an active needle‐electrode introduced into the neoplastic tissue . The resultant movement generated frictional heating which leads to cell death by means of coagulative necrosis . Therefore, heat deposition in tumor tissue is an important factor affecting efficacy of RFA treatment .…”
Section: Discussionmentioning
confidence: 99%
“…It is conceivable that the lack of effect of subsequent ablation attempted at the same initial site might be due to the presence of superficial tissue edema, which is also supportive of an intramural site of origin, and that a more aggressive initial ablation approach with higher power and longer lesion duration may have resulted in lasting VA elimination in more patients when targeting the initial site. Similarly, it is possible that different ablation approaches including supplemental ablation from multiple adjacent vantage points irrespective of the results of activation mapping, or the use of simultaneous unipolar/bipolar ablation, or half‐normal saline irrigation may have been beneficial in the two patients in whom success was not achieved.…”
Section: Study Limitationsmentioning
confidence: 99%
“…27 Use of half-normal saline as the irrigant for open-irrigated RF ablation using a standard ablation catheter (ThermoCool SmartTouch or ThermoCool SF, Biosense Webster) was another nonstandard ablation approach employed. 28,29 With each of these strategies, temperature and power settings and radiofrequency application endpoints were similar to those used for conventional radiofrequency ablation. Each of these strategies had been studied or developed in animal studies in our biophysics and large-animal electrophysiology laboratories; knowledge and familiarity with the techniques and limitations were thus able to be transferred relatively easily to the clinical care setting.…”
Section: Ablation Strategies and Endpointsmentioning
confidence: 99%