Radiofrequency at 2.45 GHz increases toxicity, pro-inflammatory and pre-apoptotic activity caused by black carbon in the RAW 264.7 macrophage cell line

Sueiro-Benavides, Rosa Ana; Leiro, J.; Salas-Sánchez, Aarón Ángel; Rodríguez‐González, J. A.; Ares‐Pena, F.

doi:10.1016/j.scitotenv.2020.142681

Cited by 21 publications

(16 citation statements)

References 69 publications

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“…This effect increased with the duration of exposure, regardless of whether 900 MHz, 2.45 GHz, or a combination (SAR: 80-400 mW) was applied. On the other hand, 2.45 GHz RF-EMF (SAR: 0.4 W/kg) promoted phagocytosis of co-exposed black carbon particles, changed the immune response, and increased NO production and cell toxicity [137].…”

Section: Radical Formation In Emf-exposed Cells Of the Blood And Immune Systemmentioning

confidence: 99%

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Manmade Electromagnetic Fields and Oxidative Stress—Biological Effects and Consequences for Health

Schuermann

Mevissen

2021

IJMS

111

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Concomitant with the ever-expanding use of electrical appliances and mobile communication systems, public and occupational exposure to electromagnetic fields (EMF) in the extremely-low-frequency and radiofrequency range has become a widely debated environmental risk factor for health. Radiofrequency (RF) EMF and extremely-low-frequency (ELF) MF have been classified as possibly carcinogenic to humans (Group 2B) by the International Agency for Research on Cancer (IARC). The production of reactive oxygen species (ROS), potentially leading to cellular or systemic oxidative stress, was frequently found to be influenced by EMF exposure in animals and cells. In this review, we summarize key experimental findings on oxidative stress related to EMF exposure from animal and cell studies of the last decade. The observations are discussed in the context of molecular mechanisms and functionalities relevant to health such as neurological function, genome stability, immune response, and reproduction. Most animal and many cell studies showed increased oxidative stress caused by RF-EMF and ELF-MF. In order to estimate the risk for human health by manmade exposure, experimental studies in humans and epidemiological studies need to be considered as well.

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Section: Radical Formation In Emf-exposed Cells Of the Blood And Immune Systemmentioning

confidence: 99%

“…Observations in this direction have also been made in cell studies. For instance, it was shown that immune responses and phagocytosis were altered by RF-EMF exposure [95,[134][135][136][137].…”

Section: Assessment Of Emf Effects On Blood and Immune Organsmentioning

confidence: 99%

Manmade Electromagnetic Fields and Oxidative Stress—Biological Effects and Consequences for Health

Schuermann

Mevissen

2021

IJMS

111

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“…The induction of phagocytic activity by heat-treated L. brevis KU15159 was similar to that by L. rhamnosus GG. The phagocytic activity of macrophages is important to defend their host against pathogens, which is crucial for immunity [30].…”

Section: Discussionmentioning

confidence: 99%

Immune-Enhancing Effect of Heat-Treated Levilactobacillus brevis KU15159 in RAW 264.7 Cells

Hwang

Kim²,

Lee

et al. 2022

Probiotics & Antimicro. Prot.

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Probiotics are alive microbes that present beneficial to the human's health. They influence immune responses through stimulating antibody production, activating T cells, and altering cytokine expression. The probiotic characteristics of Levilactobacillus brevis KU15159 were evaluated on the tolerance and adherence to gastrointestinal conditions. L. brevis KU15159 was safe in a view of producing various useful enzymes and antibiotic sensitivity. Heat-treated L. brevis KU15159 increased production of nitric oxide (NO) and phagocytic activity in RAW 264.7 cells. In addition, heat-treated L. brevis KU15159 upregulated the expression of inducible nitric oxide synthase (iNOS) and proinflammatory cytokines including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, at protein as well as mRNA levels. In addition, the mitogen-activated protein kinase (MAPK) pathway, which regulates the immune system, was activated by heat-treated L. brevis KU15159. Therefore, L. brevis KU15159 exhibited an immune-enhancing effect by the MAPK pathway in macrophage.

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“…Indeed, reactive oxygen and nitrogen species reinforce IR cytotoxicity. Counteracting the onset of oxidative stress conditions prevents structural and functional disruption of nucleic acids, proteins and lipids, and a series of processes (e.g., mitochondrial depolarization), which irreversibly lead to cell death [ 16 ]. IR-induced genomic instability is the main target to encompass, as mutations, gene amplification and other cytogenetic rearrangements could be also after the initial insult [ 17 ].…”

Section: Radioprotection: a Valuable Approach To Counteract Radiation Exposurementioning

confidence: 99%

“…PUMA inhibitors (PUMAi) are designed to inhibit PUMA-dependent and radiation-induced apoptosis and to avoid or alleviate intestinal damage and apoptosis induced by inflammatory cytokines, ROS (reactive oxygen species), or cancer therapy [22]. nucleic acids, proteins and lipids, and a series of processes (e.g., mitochondr depolarization), which irreversibly lead to cell death [16]. IR-induced genomic instabil is the main target to encompass, as mutations, gene amplification and other cytogene rearrangements could be also after the initial insult [17].…”

Section: Radioprotection: a Valuable Approach To Counteract Radiation Exposurementioning

confidence: 99%

Could Polyphenols Really Be a Good Radioprotective Strategy?

et al. 2021

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Currently, radiotherapy is one of the most effective strategies to treat cancer. However, deleterious toxicity against normal cells indicate for the need to selectively protect them. Reactive oxygen and nitrogen species reinforce ionizing radiation cytotoxicity, and compounds able to scavenge these species or enhance antioxidant enzymes (e.g., superoxide dismutase, catalase, and glutathione peroxidase) should be properly investigated. Antioxidant plant-derived compounds, such as phenols and polyphenols, could represent a valuable alternative to synthetic compounds to be used as radio-protective agents. In fact, their dose-dependent antioxidant/pro-oxidant efficacy could provide a high degree of protection to normal tissues, with little or no protection to tumor cells. The present review provides an update of the current scientific knowledge of polyphenols in pure forms or in plant extracts with good evidence concerning their possible radiomodulating action. Indeed, with few exceptions, to date, the fragmentary data available mostly derive from in vitro studies, which do not find comfort in preclinical and/or clinical studies. On the contrary, when preclinical studies are reported, especially regarding the bioactivity of a plant extract, its chemical composition is not taken into account, avoiding any standardization and compromising data reproducibility.

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Radiofrequency at 2.45 GHz increases toxicity, pro-inflammatory and pre-apoptotic activity caused by black carbon in the RAW 264.7 macrophage cell line

Cited by 21 publications

References 69 publications

Manmade Electromagnetic Fields and Oxidative Stress—Biological Effects and Consequences for Health

Manmade Electromagnetic Fields and Oxidative Stress—Biological Effects and Consequences for Health

Immune-Enhancing Effect of Heat-Treated Levilactobacillus brevis KU15159 in RAW 264.7 Cells

Could Polyphenols Really Be a Good Radioprotective Strategy?

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