Radiofrequency echographic multi spectrometry for the prediction of incident fragility fractures: A 5-year follow-up study

Adami, Giovanni; Arioli, G.; Bianchi, Gerolamo; Brandi, Maria Luisa; Caffarelli, Carla; Cianferotti, Luisella; Gatti, Davide; Girasole, G.; Gonnelli, Stefano; Manfredini, M.; Muratore, Maurizio; Quarta, E.; Quarta, L.

doi:10.1016/j.bone.2020.115297

Cited by 53 publications

(85 citation statements)

References 45 publications

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“…Bone degenerations, presence of osteophytes and calcifications contribute to higher results of BMD, especially in the lumbar area [8]. Preliminary research has reported that the REMS method should be able to automatically remove signals that arise from artifacts like calcifications and osteophytes [31], which makes REMS a potentially beneficial method in bone assessment in acromegaly. Further investigations and evaluation of BMD by REMS among patients with active acromegaly and osteoarthritis are necessary.…”

Section: Discussionmentioning

confidence: 99%

Bone densitometry by radiofrequency echographic multi-spectrometry (REMS) in acromegaly patients

Rolla

Halupczok-Żyła

Jawiarczyk-Przybyłowska

et al. 2020

Endokrynologia Polska

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Introduction: Radiofrequency echographic multi-spectrometry (REMS) is a recently introduced non-ionising technology employed in the evaluation of osteoporosis. The aim of our study was to compare bone mineral density (BMD) in acromegaly patients and healthy controls by performing novel REMS densitometry. The second objective was to analyse the correlation between results of REMS and classical dual-energy X-ray absorptiometry (DXA) in acromegaly patients. 2 Material and methods: We enrolled 33 patients with acromegaly (AG) and 24 controls (CG). The acromegaly patients were divided into two subgroups: well-controlled acromegaly (WCA) and surgery-cured acromegaly (SCA). REMS was performed in all participants, while DXA was performed only in the acromegaly group. IGF-I and GH levels were measured in acromegaly patients. Results: Bone mineral density of the lumbar spine (LS) and the femoral neck (FN) obtained from REMS did not reveal significant differences between AG, CG, WCA, and SCA. Similarly, there were no significant differences in BMD measured by DXA at the LS and at the FN between WCA and SCA. Significant positive correlations between IGF-I concentrations and BMD obtained from both REMS and DXA were detected in the AG and WCA. In the AG and WCA, there were positive correlations between T-scores and LS BMD obtained from both methods. Conclusions: Radiofrequency echographic multi-spectrometry is a potential method in assessment of bone status in acromegaly. Further studies with participation of active disease patients are needed.

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Section: Discussionmentioning

confidence: 99%

Bone densitometry by radiofrequency echographic multi-spectrometry (REMS) in acromegaly patients

Rolla

Halupczok-Żyła

Jawiarczyk-Przybyłowska

et al. 2020

Endokrynologia Polska

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“…Prospective studies that can demonstrate the usefulness of REMS in predicting osteoporotic fractures would have the greatest clinical value. Up to date, only one study by Adami et al assessed that issue prospectively, showing promising results [15]. Finally, we did not assess the intra-operator repeatability.…”

Section: Discussionmentioning

confidence: 94%

“…Failure to adhere to strict DXA measurement principles can lead to a high percentage of erroneous BMD reports in everyday clinical practice [12,13]. Radiofrequency Echographic Multi Spectrometry (REMS), an innovative quantitative ultrasound technique for osteoporosis diagnosis in the proximal femur and lumbar spine, has been recently validated in a few clinical studies, showing promising results [14][15][16]. REMS has been approved by the Food and Drug Administration in October 2018 and rated as a valuable approach for osteoporosis diagnosis and fracture risk prediction by ESCEO [17].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic agreement between radiofrequency echographic multispectrometry and dual-energy X-ray absorptiometry in the assessment of osteoporosis in a Polish group of patients

Nowakowska-Płaza¹,

Wroński²,

Płaza³

et al. 2021

Polish Archives of Internal Medicine

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This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC BY-NC-SA 4.0), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited, distributed under the same license, and used for noncommercial purposes only.

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“…For example, Adami et al 44 35,45 . The method considers variations of porosity as a major source of variations of cortical bone elasticity, sound velocity and fracture toughness in postmenopausal women [46][47][48] .…”

Section: Discrimination Performancementioning

confidence: 99%

Cortical pore size distribution and viscoelastic tibia properties discriminate fragility fractures independent of bone mineral density

Raum

Armbrecht

Minh

et al. 2021

Preprint

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Osteoporosis is a disorder of bone remodeling leading to reduced bone mass, structural deterioration, and increased bone fragility. The established diagnosis is based on the measurement of areal bone mineral density by dual energy x-ray absorptiometry (DXA), which poorly captures individual bone loss and structural decay. Enlarged cortical pores in the tibia have been proposed to indicate structural deterioration and reduced bone strength in the hip. Here, we report for the first time the in-vivo assessment of the cortical pore size distribution together with viscoelastic bone properties by means of a novel ultrasonic cortical backscatter (CortBS) technology to discriminate between fractured and nonfractured postmenopausal women (N = 55). The discrimination performance was benchmarked with DXA and high-resolution peripheral computed tomography (HR-pQCT). The results suggest a superior discrimination performance of CortBS (area under the receiver operating characteristic curve: 0.69 ≤ AUC ≤ 0.75) compared to DXA (0.53 ≤ AUC ≤ 0.55) and a similar performance compared to HR-pQCT (0.68 ≤ AUC ≤ 0.73).

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Radiofrequency echographic multi spectrometry for the prediction of incident fragility fractures: A 5-year follow-up study

Cited by 53 publications

References 45 publications

Bone densitometry by radiofrequency echographic multi-spectrometry (REMS) in acromegaly patients

Bone densitometry by radiofrequency echographic multi-spectrometry (REMS) in acromegaly patients

Diagnostic agreement between radiofrequency echographic multispectrometry and dual-energy X-ray absorptiometry in the assessment of osteoporosis in a Polish group of patients

Cortical pore size distribution and viscoelastic tibia properties discriminate fragility fractures independent of bone mineral density

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