Radiofrequency electromagnetic radiation from cell phone causes defective testicular function in male Wistar rats

Oyewopo, Adeoye Oyetunji; Olaniyi, Kehinde S.; Oyewopo, Christianah I; Ak, Jimoh

doi:10.1111/and.12772

Cited by 43 publications

(28 citation statements)

References 14 publications

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“…Signifi cantly decreased LH in the EMR group suggested that cellphone radiation has a central effect on LH (hypothalamic or hypophyseal). Similar to the fi ndings of Meo et al, we also observed a considerable decrease of T levels (10,45), suggesting that cellphone waves had a negative effect on Leydig cells. That the treatment and control groups have close serum T levels also suggests that Egb761 protected Leydig cells from the cellphone EMR.…”

supporting

confidence: 91%

“…Many factors, such as testicular torsion, infections, cryptorchidism, gonadal dysgenesis, varicocele, medication, and EMR can unfavorably affect spermatogenesis and lead to infertility (8). Chronic exposure to radiofrequency electromagnetic radiation of cell phone leads to defective testicular function that is associated with increased oxidative stress (9) and decreased gonadotropic hormones (FSH, LH, T) profi le (10).…”

Section: Introductionmentioning

confidence: 99%

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Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system

Gevrek¹,

Aydın²,

Ozsoy³

et al. 2017

BLL

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OBJECTIVES: To determine the effects of Egb761 on testicular tissues and semen parameters in rats exposed to cellphone waves. BACKGROUND: EGb761 has antioxidant properties as a free-radical scavenger. Cellphone electromagnetic radiation (EMR) induces oxidative stress in cells. METHODS: Twenty-one Wistar albino male adult rats were divided into three groups (control, experimental, treatment), including seven rats in each. The experimental and treatment groups were exposed to cellphone EMR (0.96 W/kg) for six weeks (4 hrs/day). Egb761 (100 mg/kg/day) was also added to the treatment. Testes, epididymal semen and blood plasma were used for analysis. RESULTS: Exposure to cellular phone radiation resulted in a signifi cant impairment in testicular morphometry and histological structure, reduction of total and motile sperm numbers and plasma testosterone level. Egb761 administration improved testicular damage and led to a marked increase in plasma testosterone levels and total and motile sperm numbers. CONCLUSION: Male reproductive system is susceptible to cellphone radiation. Cellphone waves induce toxic effects in testicular tissues, impair spermatogenesis and cause an imbalance in testosterone hormone levels. Egb761 ameliorated these toxic effects by reversing testicular tissue damage, restoring normal spermatogenesis and hormone levels. This suggests that Egb761 is a potential therapeutic agent against EMR-induced male reproductive toxicity (Tab. 3, Fig. 6, Ref. 45). Text in PDF www.elis.sk.

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supporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system

Gevrek¹,

Aydın²,

Ozsoy³

et al. 2017

BLL

View full text Add to dashboard Cite

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“…On the other hand, approximately 48.5 million couples suffer from infertility, and 20 to 30 per cent of them are due to male infertility without any known cause (Agarwal, Mulgund, Hamada, & Chyatte, 2015). Some studies confirmed that the nonthermal mechanism is the cause of the destructive effect of radiofrequency electromagnetic radiation (RF‐EMR) (Nizhelska, Marynchenko, & Piasetskyi, 2020), such as reactive oxygen species (ROS), which leads to lipid peroxidation and induction of oxidative stress (Oyewopo, Olaniyi, Oyewopo, & Jimoh, 2017) and apoptosis (Li et al., 2020). Malondialdehyde (MDA) is a final lipid peroxidation product that has toxic effects on tissues such as the kidney, liver, blood, heart, brain and spermatozoa after exposure to EMR (Adebayo, Adeeyo, Ogundiran, & Olabisi, 2019; Berköz et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

The protective effect of melatonin on radiofrequency electromagnetic fields of mobile phone‐induced testicular damage in an experimental mouse model

et al. 2020

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Radiofrequency electromagnetic radiation (RF‐EMR) from mobile devices has undesirable effects on the male reproductive organs. Melatonin with antioxidant potential can help to prevent these damages. Therefore, the aim of this study was to evaluate the protective effect of melatonin on testicular damage induced by RF‐EMR of mobile phone. In this experimental study, 32 adult male BALB/c mice were divided randomly into four groups: control, melatonin (2 mg/kg, for 30 consecutive days, intraperitoneally), RF‐EMR (900 MHz, 100 to 300 MT, 54 to 160 W/m) (4 hr per day, whole body) and melatonin + RF‐EMR groups. One day after the last prescription were evaluated oxidative stress parameters, testosterone level and histopathological assays of the testis. EMR of mobile phone led to the induction of oxidative stress, testicular tissue damage and decreased testosterone. Treatment with melatonin improved oxidative stress parameters such as MDA and GSH, and testis injury score, increased the thickness of the germinal epithelial thickness and diameter of the seminiferous tubule, and decreased testosterone hormone in the EMR‐exposed mice, and these differences were significant(p < .05). Data showed that melatonin with its antioxidant property can decrease oxidative damage induced by RF‐EMR of mobile phones on testis tissue.

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“…After a large dose of radiation for a long time, there may be atrophy of seminiferous tubules, reduction of spermatogenic cells, disorder of the arrangement, reduction of mature sperm and disorder of epidermal secretion. Study [10] shows long time exposure to mobile phone radiation rat gonadotropin decreased significantly, resulting in testicular dysfunction, increased oxidative stress, but also research shows that [11] RF radiation can significantly affect the sperm count and sperm deformity rate, but does not include sperm motility.…”

Section: Common Physical Chemical Natural Environmentmentioning

confidence: 99%

The influence of environmental factors on male fertility and its research progress

Li¹,

Li²

2017

Proceedings of the 2017 3rd International Conference on Economics, Social Science, Arts, Education and Management Engineering (

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Abstract. Male fertility in recent years decreased rapidly, people gradually pay more attention to environmental factors, which is one of the important reasons, in order to explore and analyze the different effects of environmental factors on male fertility, of all kinds of factors, suggesting that people try to avoid damaging the environment function, pay attention to protect their fertility, prevent or slow down the process of male fertility decline. By analyzing various environmental factors leading to the decrease of male fertility, it is concluded that the reduction of male fertility is due to the combined effects of many factors, among which environmental pollution is the most important factor.There are numerous factors that lead to male infertility, including congenital or acquired urogenital malformations, urogenital infections, endocrine disorders, genetic diseases, immunological factors, and environmental factors. But there are still 30% -40% of patients with unknown cause of disease [1]. The decline of human fertility is a gradual process. As people go deep into the study, they gradually give attention to the influence of environment on fertility. Effects of alcohol and tobacco on male fertilityEffects of cigarette smoking on male fertility. There are about 37% [2] of the men of childbearing age smoking, smoking people in our country, the number of about 350 million, suffering from the hazards of passive smoking as high as 540 million numbers [3] . Testicular function is vulnerable to harmful substances in cigarettes, including the sperm DNA integrity and semen quality and sexual function, smoking increases ROS, resulting in oxidative stress, damage sperm function, there is evidence for a genetic and epigenetic Table [4] shows that smoking can eventually lead to male infertility.Influences of alcohol consumption on male fertility. Drinking will also affect male fertility, the regulating effects of neuroendocrine gonadal axis, through direct effects on testis spermatogenic and hormone produced in the environment affected by the effects on sperm quality led to a decline in the number of hormone levels decreased by [5] . Studies have shown that the incidence of [6] male infertility is associated with heavy drinking, and alcohol consumption may be one of the principal causes of male infertility. Common physical, chemical, natural environmentRadiations. Thermal radiation. Spermatogenesis is highly sensitive to temperature changes, and the temperature of the scrotum increases by 1-2 DEG C, which inhibits sperm production by [7]. High temperature (> 36 C) inhibited the proliferation of Sertoli cells, integrity between Sertoli cells by high value-added and value-added cells or his contact between cells, reduce the male fertility of [8], leading to sperm maturity is not enough, affect the survival rate of sperm.Cold conditions also have an impact on them. A study of therapy shows that [9] low temperatures can cause Leydig cells and Sertoli cells to undergo proliferation, and a large number of B type spermatogo...

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Radiofrequency electromagnetic radiation from cell phone causes defective testicular function in male Wistar rats

Cited by 43 publications

References 14 publications

Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system

Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system

The protective effect of melatonin on radiofrequency electromagnetic fields of mobile phone‐induced testicular damage in an experimental mouse model

The influence of environmental factors on male fertility and its research progress

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