Radiofrequency electromagnetic radiation-induced behavioral changes and their possible basis

Narayanan, Sareesh Naduvil; Jetti, Raghu; Kesari, Kavindra Kumar; Kumar, Raju Suresh; Nayak, Satheesha B.; Bhat, Pallavi

doi:10.1007/s11356-019-06278-5

Cited by 53 publications

(36 citation statements)

References 101 publications

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“…Previous studies have explored that RF-EMF exposure inhibits calcium influx, causes oxidative stress, and induces DNA injury (Altun et al, 2018;Kim et al, 2018a). These effects might cause downstream effects such as changing the expression of specific genes, modifying the morphology of the nervous system, and even leading to impairment of cognitive functions (Keles et al, 2018;Kim et al, 2019a;Narayanan et al, 2019). The Eph receptors are multitalented tyrosine kinases that perform many tasks.…”

Section: Discussionmentioning

confidence: 99%

1800 MHz Radiofrequency Electromagnetic Field Impairs Neurite Outgrowth Through Inhibiting EPHA5 Signaling

Chen

Deng

et al. 2021

Front. Cell Dev. Biol.

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The increasing intensity of environmental radiofrequency electromagnetic fields (RF-EMF) has increased public concern about its health effects. Of particular concern are the influences of RF-EMF exposure on the development of the brain. The mechanisms of how RF-EMF acts on the developing brain are not fully understood. Here, based on high-throughput RNA sequencing techniques, we revealed that transcripts related to neurite development were significantly influenced by 1800 MHz RF-EMF exposure during neuronal differentiation. Exposure to RF-EMF remarkably decreased the total length of neurite and the number of branch points in neural stem cells-derived neurons and retinoic acid-induced Neuro-2A cells. The expression of Eph receptors 5 (EPHA5), which is required for neurite outgrowth, was inhibited remarkably after RF-EMF exposure. Enhancing EPHA5 signaling rescued the inhibitory effects of RF-EMF on neurite outgrowth. Besides, we identified that cAMP-response element-binding protein (CREB) and RhoA were critical downstream factors of EPHA5 signaling in mediating the inhibitory effects of RF-EMF on neurite outgrowth. Together, our finding revealed that RF-EMF exposure impaired neurite outgrowth through EPHA5 signaling. This finding explored the effects and key mechanisms of how RF-EMF exposure impaired neurite outgrowth and also provided a new clue to understanding the influences of RF-EMF on brain development.

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Section: Discussionmentioning

confidence: 99%

1800 MHz Radiofrequency Electromagnetic Field Impairs Neurite Outgrowth Through Inhibiting EPHA5 Signaling

Chen

Deng

et al. 2021

Front. Cell Dev. Biol.

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“…In recent years, the growing percentage of neurodegenerative diseases has been attributed to an induced oxidative stress array of human health, environment, and lifestyle factors [ 1 , 2 ]. It is known that the physiology of neurodegenerative diseases is multifactorial, and several recent studies confirm that potential superficial factors like radiation [ 3 , 4 ] or chemical compound exposures [ 5 , 6 , 7 ] are associated with the risk of the onset of neuronal diseases. Exogenous compounds such as menadione (MQ) (2-methyl-1,4-naphthoquinone), offer an examination of the oxidative stress-induced cytotoxicity in the cell, where due to the formation of reactive oxygen species (ROS), the cell either becomes dysfunctional or dies ( Figure 1 ) [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Plant-Derived Natural Biomolecule Picein Attenuates Menadione Induced Oxidative Stress on Neuroblastoma Cell Mitochondria

et al. 2020

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Several bioactive compounds are in use for the treatment of neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. Historically, willow (salix sp.) bark has been an important source of salisylic acid and other natural compounds with anti-inflammatory, antipyretic and analgesic properties. Among these, picein isolated from hot water extract of willow bark, has been found to act as a natural secondary metabolite antioxidant. The aim of this study was to investigate the unrevealed pharmacological action of picein. In silico studies were utilized to direct the investigation towards the neuroprotection abilities of picein. Our in vitro studies demonstrate the neuroprotective properties of picein by blocking the oxidative stress effects, induced by free radical generator 2-methyl-1,4-naphthoquinone (menadione, MQ), in neuroblastoma SH-SY5Y cells. Several oxidative stress-related parameters were evaluated to measure the protection for mitochondrial integrity, such as mitochondrial superoxide production, mitochondrial activity (MTT), reactive oxygen species (ROS) and live-cell imaging. A significant increase in the ROS level and mitochondrial superoxide production were measured after MQ treatment, however, a subsequent treatment with picein was able to mitigate this effect by decreasing their levels. Additionally, the mitochondrial activity was significantly decreased by MQ exposure, but a follow-up treatment with picein recovered the normal metabolic activity. In conclusion, the presented results demonstrate that picein can significantly reduce the level of MQ-induced oxidative stress on mitochondria, and thereby plays a role as a potent neuroprotectant.

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“…Radiofrequency radiation can elicit carcinogenic, genotoxic, reproductive, developmental, neurological, and cognitive effects [52][53][54]. Continuously increasing exposure to radiofrequency radiation from wireless communication devices and sources brings urgency to the question of health-protective limits for such exposures.…”

Section: Discussionmentioning

confidence: 99%

Development of health-based exposure limits for radiofrequency radiation from wireless devices using a benchmark dose approach

Uche

Naidenko

2021

Environ Health

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Background Epidemiological studies and research on laboratory animals link radiofrequency radiation (RFR) with impacts on the heart, brain, and other organs. Data from the large-scale animal studies conducted by the U.S. National Toxicology Program (NTP) and the Ramazzini Institute support the need for updated health-based guidelines for general population RFR exposure. Objectives The development of RFR exposure limits expressed in whole-body Specific Absorption Rate (SAR), a metric of RFR energy absorbed by biological tissues. Methods Using frequentist and Bayesian averaging modeling of non-neoplastic lesion incidence data from the NTP study, we calculated the benchmark doses (BMD) that elicited a 10% response above background (BMD10) and the lower confidence limits on the BMD at 10% extra risk (BMDL10). Incidence data for individual neoplasms and combined tumor incidence were modeled for 5% and 10% response above background. Results Cardiomyopathy and increased risk of neoplasms in male rats were the most sensitive health outcomes following RFR exposures at 900 MHz frequency with Code Division Multiple Access (CDMA) and Global System for Mobile Communications (GSM) modulations. BMDL10 for all sites cardiomyopathy in male rats following 19 weeks of exposure, calculated with Bayesian model averaging, corresponded to 0.27–0.42 W/kg whole-body SAR for CDMA and 0.20–0.29 W/kg for GSM modulation. BMDL10 for right ventricle cardiomyopathy in female rats following 2 years of exposure corresponded to 2.7–5.16 W/kg whole-body SAR for CDMA and 1.91–2.18 W/kg for GSM modulation. For multi-site tumor modeling using the multistage cancer model with a 5% extra risk, BMDL5 in male rats corresponded to 0.31 W/kg for CDMA and 0.21 W/kg for GSM modulation. Conclusion BMDL10 range of 0.2—0.4 W/kg for all sites cardiomyopathy in male rats was selected as a point of departure. Applying two ten-fold safety factors for interspecies and intraspecies variability, we derived a whole-body SAR limit of 2 to 4 mW/kg, an exposure level that is 20–40-fold lower than the legally permissible level of 0.08 W/kg for whole-body SAR under the current U.S. regulations. Use of an additional ten-fold children’s health safety factor points to a whole-body SAR limit of 0.2–0.4 mW/kg for young children.

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Radiofrequency electromagnetic radiation-induced behavioral changes and their possible basis

Cited by 53 publications

References 101 publications

1800 MHz Radiofrequency Electromagnetic Field Impairs Neurite Outgrowth Through Inhibiting EPHA5 Signaling

1800 MHz Radiofrequency Electromagnetic Field Impairs Neurite Outgrowth Through Inhibiting EPHA5 Signaling

Plant-Derived Natural Biomolecule Picein Attenuates Menadione Induced Oxidative Stress on Neuroblastoma Cell Mitochondria

Development of health-based exposure limits for radiofrequency radiation from wireless devices using a benchmark dose approach

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