1982
DOI: 10.1016/0022-4731(82)90209-6
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Radioimmunoassay of plasma and urine 6β-hydroxycortisol: Levels in healthy adults and in hypercortisolemic states

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Cited by 34 publications
(13 citation statements)
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“…The h.p.l.c. method we used was validated on the basis of the following points: (1) Our data for healthy adults were in good agreement with previously published values (Dumont et al, 1984;Nakamura & Yakata, 1985;Hosoda et al, 1981;Kishida & Fukushima, 1983;Nahoul et al, 1982;Park, 1978;Zhiri et al, 1986;Desage et al, 1987). (2) In addition we had the opportunity, in a separate study, to perform both our h.p.l.c.…”
Section: Other Monooxygenase Assayssupporting
confidence: 79%
See 1 more Smart Citation
“…The h.p.l.c. method we used was validated on the basis of the following points: (1) Our data for healthy adults were in good agreement with previously published values (Dumont et al, 1984;Nakamura & Yakata, 1985;Hosoda et al, 1981;Kishida & Fukushima, 1983;Nahoul et al, 1982;Park, 1978;Zhiri et al, 1986;Desage et al, 1987). (2) In addition we had the opportunity, in a separate study, to perform both our h.p.l.c.…”
Section: Other Monooxygenase Assayssupporting
confidence: 79%
“…Various h.p.l.c. systems, as well as immunoassays, have been described for this measurement (Dumont et al, 1984;Nakamura & Yakata, 1985;Hosoda et al, 1981;Kishida & Fukushima, 1983;Nahoul et al, 1982;Park, 1978;Zhiri et al, 1986;Desage et al, 1987). The h.p.l.c.…”
Section: Other Monooxygenase Assaysmentioning
confidence: 99%
“…Wheth er the fetal pituitary has a rhythm of its own or is dependent on maternal corticosteroid rhythm is difficult to determine in the hu man model. There is nothing in this study which would confirm or refute bp-hydroxycortisol as being a purely fetal adrenal me tabolite, although other investigators have found it in healthy adults [10,11]. It will be interesting to measure both 6p-hydroxycortisol and cortisol in blood of patients in sus pected premature labor and relate the levels to pregnancy outcome.…”
Section: Discussionmentioning
confidence: 94%
“…In general, an increase in 6beta-HC:cortisol indicates that the drug may be a potential CYP3A4 inducer and a decrease in the ratio indicates that the drug may be a CYP3A4 inhibitor. Several methods for determinations of 6beta-HC:cortisol in human urine have been published based on enzyme linked immunosorbent assay (ELISA) [8], Radioimmunoassay (RIA) [9], high performance liquid chromatography (HPLC) [10][11][12][13][14][15][16][17] and liquid chromatography-tandem mass spectrometry (LC-MS/MS) [18]. Immunochemical results have been shown to overestimate both 6beta-HC and cortisol concentrations due to antibody cross-reactivity with other structurally similar steroids [8].…”
Section: Introductionmentioning
confidence: 98%