Radiolabeled Gold Nanoparticles for Imaging and Therapy of Cancer

Silva, Francisco; Campello, Maria Paula Cabral; Paulo, António

doi:10.3390/ma14010004

Cited by 51 publications

(34 citation statements)

References 135 publications

(248 reference statements)

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“…Tumor presents a multifactorial etiology, which makes it an extremely complex and heterogeneous disease, attributed to an almost unique expression of biomarkers from patient to patient. To circumvent this complexity, the development of so-called precision and personalized medicine is pivotal towards the battle against cancer ( 16 ). One of the major strategies is through the combination of nuclear medicine modalities and nanotechnology to offer unique opportunities to develop an effective single chemical entity with diagnostic and therapeutic capabilities for clinical applications in theranostic nanoradiopharmaceuticals.…”

Section: Methods Of Radiosynthesis Of Nanoparticlesmentioning

confidence: 99%

Recent Advances in Brachytherapy Using Radioactive Nanoparticles: An Alternative to Seed-Based Brachytherapy

et al. 2021

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Interstitial brachytherapy (BT) is generally used for the treatment of well-confined solid tumors. One example of this is in the treatment of prostate tumors by permanent placement of radioactive seeds within the prostate gland, where low doses of radiation are delivered for several months. However, successful implementation of this technique is hampered due to several posttreatment adverse effects or symptoms and operational and logistical complications associated with it. Recently, with the advancements in nanotechnology, radioactive nanoparticles (radio-NPs) functionalized with tumor-specific biomolecules, injected intratumorally, have been reported as an alternative to seed-based BT. Successful treatment of solid tumors using radio-NPs has been reported in several preclinical studies, on both mice and canine models. In this article, we review the recent advancements in the synthesis and use of radio-NPs as a substitute to seed-based BT. Here, we discuss the limitations of current seed-based BT and advantages of radio-NPs for BT applications. Recent progress on the types of radio-NPs, their features, synthesis methods, and delivery techniques are discussed. The last part of the review focuses on the currently used dosimetry protocols and studies on the dosimetry of nanobrachytherapy applications using radio-NPs. The current challenges and future research directions on the role of radio-NPs in BT treatments are also discussed.

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Section: Methods Of Radiosynthesis Of Nanoparticlesmentioning

confidence: 99%

Recent Advances in Brachytherapy Using Radioactive Nanoparticles: An Alternative to Seed-Based Brachytherapy

et al. 2021

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“…RIT has been introduced into oncology treatment through directly delivering therapeutic radionuclides into tumors [42][43][44]. Many recent studies have shown that the targeted delivery of radioisotopes via the utilization of nanoplatforms may effectively improve its bioavailability and minimize radiotoxicity to normal organs [45][46][47]. Moreover, RIT combined with other therapies and modulated by nanoparticle platforms has shown significant synergistic effect in recent studies [48,49].…”

Section: Nanomaterials For Ritmentioning

confidence: 99%

Advances of Nanomedicine in Radiotherapy

et al. 2021

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Radiotherapy (RT) remains one of the current main treatment strategies for many types of cancer. However, how to improve RT efficiency while reducing its side effects is still a large challenge to be overcome. Advancements in nanomedicine have provided many effective approaches for radiosensitization. Metal nanoparticles (NPs) such as platinum-based or hafnium-based NPs are proved to be ideal radiosensitizers because of their unique physicochemical properties and high X-ray absorption efficiency. With nanoparticles, such as liposomes, bovine serum albumin, and polymers, the radiosensitizing drugs can be promoted to reach the tumor sites, thereby enhancing anti-tumor responses. Nowadays, the combination of some NPs and RT have been applied to clinical treatment for many types of cancer, including breast cancer. Here, as well as reviewing recent studies on radiotherapy combined with inorganic, organic, and biomimetic nanomaterials for oncology, we analyzed the underlying mechanisms of NPs radiosensitization, which may contribute to exploring new directions for the clinical translation of nanoparticle-based radiosensitizers.

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“…Nanoparticles with dimensions lower than 100 nm can pass through these broken vessels, and they can migrate inside the tumor and remain there for a longer period of time, as compared with nanoparticle clearance in the blood (EPR phenomenon). Passive targeting is limited, because not all the cancerous tumors in the human body exhibit the EPR phenomenon and the permeability grade of the tumoral vascular system is not homogenous [89,90].…”

Section: Applications Of Magnetic Nanoparticles In Cancer Therapymentioning

confidence: 99%

Magnetic Nanoparticles Used in Oncology

et al. 2021

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Recently, magnetic nanoparticles (MNPs) have more and more often been used in experimental studies on cancer treatments, which have become one of the biggest challenges in medical research. The main goal of this research is to treat and to cure advanced or metastatic cancer with minimal side effects through nanotechnology. Drug delivery approaches take into account the fact that MNPs can be bonded to chemotherapeutical drugs, nucleic acids, synthetized antibodies or radionuclide substances. MNPs can be guided, and different treatment therapies can be applied, under the influence of an external magnetic field. This paper reviews the main MNPs’ synthesis methods, functionalization with different materials and highlight the applications in cancer therapy. In this review, we describe cancer cell monitorization based on different types of magnetic nanoparticles, chemotherapy, immunotherapy, magnetic hyperthermia, gene therapy and ferroptosis. Examples of applied treatments on murine models or humans are analyzed, and glioblastoma cancer therapy is detailed in the review. MNPs have an important contribution to diagnostics, investigation, and therapy in the so called theranostics domain. The main conclusion of this paper is that MNPs are very useful in different cancer therapies, with limited side effects, and they can increase the life expectancy of patients with cancer drug resistance.

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Radiolabeled Gold Nanoparticles for Imaging and Therapy of Cancer

Cited by 51 publications

References 135 publications

Recent Advances in Brachytherapy Using Radioactive Nanoparticles: An Alternative to Seed-Based Brachytherapy

Recent Advances in Brachytherapy Using Radioactive Nanoparticles: An Alternative to Seed-Based Brachytherapy

Advances of Nanomedicine in Radiotherapy

Magnetic Nanoparticles Used in Oncology

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