Radiolabeled theranostics: magnetic and gold nanoparticles

Same, Saeideh; Aghanejad, Ayuob; Nakhjavani, Sattar Akbari; Barar, Jaleh; Omidi, Yadollah

doi:10.15171/bi.2016.23

Cited by 80 publications

(58 citation statements)

References 117 publications

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“…Among various carbon allotropes, carbon quantum dots (CQDs) have shown NIR applications by upconversion for fluorescence emission . Graphene‐based materials were shown to exhibit a NIR photothermal effect for photothermal therapy . Carbon nitride (C 3 N 4 ) is widely used as a metal‐free photocatalyst for varied applications, including H 2 evolution under visible‐light and NIR irradiation .…”

Section: Figuresupporting

confidence: 93%

“…[11] Graphene-based materials weres hown to exhibit aN IR photothermal effect for photothermal therapy. [12] Carbon nitride (C 3 N 4 )i sw idely used as am etal-free photocatalyst for varied applications, including H 2 evolution under visible-light and NIR irradiation. [13] It would be highly desirable to develop af acile approach to prepare highly porousand NIR-activec arbon materials.…”

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confidence: 99%

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One‐Step Synthesis of Dicyanobenzene‐Derived Nitrogen‐Doped Porous Carbon Monolayers: Porosity and Near‐infrared Photoactivity

et al. 2017

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We present a facile and one‐step synthesis of a N‐doped porous carbon (NPC) material by direct heating of dicyanobenzene in the presence of ZnCl2, free from any pre‐ or post‐treatment. The resultant NPC material features graphite‐like monolayers with a thickness of approximately 1.4 nm, as proven by microscopy technology. NPC shows a BET surface area of 3038.5 m2 g−1 and a narrow pore‐size distribution centered at 0.51 nm. As a consequence, NPC displays a high H2 uptake of up to 2.96 wt % at 77 K and a CO2 adsorption capability of 23.4 wt % at 278 K and 0.1 MPa. N‐doping leads to extension of the optical absorption of NPC into the near‐infrared (NIR) region. This N‐decorated carbon material, as the first example of a NIR‐triggered carbon photocatalyst, exhibits pronounced H2 production capabilities. Carbonization of aromatic multinitriles would be a general and facile approach to prepare multifunctional N‐doped carbon materials for gas storage and full solar spectrum driven photocatalysts.

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Section: Figuresupporting

confidence: 93%

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confidence: 99%

One‐Step Synthesis of Dicyanobenzene‐Derived Nitrogen‐Doped Porous Carbon Monolayers: Porosity and Near‐infrared Photoactivity

et al. 2017

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“…Importantly, all of these steps and processes can be monitored by MRI, CT (computed tomography) and other imaging techniques potentially allowing full control over the medical procedures [10][11][12]. New multimodal magnetic nanostructures have also found applications in molecular-imaging [13,14], as PET-MRI (positron emission tomography-magnetic resonance imaging) contrast agents [15], thermal therapy [16,17] targeted drug delivery and many others [18]. Our review will focus only of the recent developments of magnetic-plasmonic nanocomposites and their biological applications.…”

Section: Introductionmentioning

confidence: 99%

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

2018

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Magnetic plasmonic nanomaterials are of great interest in the field of biomedicine due to their vast number of potential applications, for example, in molecular imaging, photothermal therapy, magnetic hyperthermia and as drug delivery vehicles. The multimodal nature of these nanoparticles means that they are potentially ideal theranostic agents-i.e., they can be used both as therapeutic and diagnostic tools. This review details progress in the field of magnetic-plasmonic nanomaterials over the past ten years, focusing on significant developments that have been made and outlining the future work that still needs to be done in this fast emerging area. The review describes the main synthetic approaches to each type of magnetic plasmonic nanomaterial and the potential biomedical applications of these hybrid nanomaterials.

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“…In view of their chemical and biological features, AuNPs and AuNRs can be labeled with several radionuclides, and have been proposed as innovative tools for diagnostic imaging, for the targeted delivery of drugs, and for the radio treatment of several cancer types [31,132]. The different diagnostic and therapeutic applications of a single molecule/substance are now called theragnostic applications [133], which is one of the most promising fields of nuclear medicine [31].…”

Section: Gold Nanoparticle and Nanorods: Clinical Aspectsmentioning

confidence: 99%

“…Nanomaterials are proposed in medicine to increase the efficiency of therapies and diagnosis. In fact, in the diagnostic field, nanomaterials potentially introduce noteworthy advantages with respect to the traditional use of single molecules as radioactive tracers for in vivo and in vitro imaging [29][30][31][32]. Moreover, in therapy, nanodrug preparations are more useful than the usual low-molecular-weight drugs in many features.…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticles and Nanorods in Nuclear Medicine: A Mini Review

et al. 2019

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In the last decade, many innovative nanodrugs have been developed, as well as many nanoradiocompounds that show amazing features in nuclear imaging and/or radiometabolic therapy. Their potential uses offer a wide range of possibilities. It can be possible to develop nondimensional systems of existing radiopharmaceuticals or build engineered systems that combine a nanoparticle with the radiopharmaceutical, a tracer, and a target molecule, and still develop selective nanodetection systems. This review focuses on recent advances regarding the use of gold nanoparticles and nanorods in nuclear medicine. The up-to-date advancements will be shown concerning preparations with special attention on the dimensions and functionalizations that are most used to attain an enhanced performance of gold engineered nanomaterials. Many ideas are offered regarding recent in vitro and in vivo studies. Finally, the recent clinical trials and applications are discussed.Radiopharmaceuticals are showing amazing outcomes in diagnostic (90%) and therapeutic (10%) applications for many diseases such as cancer, heart and brain diseases, and so on [33]. They consist of a radioactive nuclide linked to a biologically active molecule directed to the target of interest. When radionuclides emit γ rays (either directly, as pure γ emitters, or indirectly, as β+ emitters), the radiopharmaceutical is intended for diagnostic imaging. When radionuclides emit β− or α particles (thanks to the cell-damaging properties) the radiopharmaceutical is used for therapeutic applications and, in some recent research studies, even for radio-guided surgery [34][35][36]. Theragnostics is a new term that implies the use of the same molecule, labeled with different radionuclides, for both diagnostic and therapeutic purposes [37][38][39].Radiopharmaceuticals have been increasingly used for medical diagnosis since the late 1940s, when nuclear medicine was born. Nuclear medicine aims at evaluating both physiological function as well as biochemical changes in disease conditions; it includes two-dimensional (2D) imaging (planar scintigraphy) and three-dimensional (3D) imaging (single-photon emission computed tomography, SPECT, and positron emission tomography, PET). The functional information obtained by SPECT and PET may need to be coupled with the anatomic/morphologic information typically provided by computed tomography (CT) (hence SPECT and PET are now commonly called SPECT-CT and PET-CT): these approaches, named "hybrid imaging", have many advantages as well as high sensitivity, good spatial resolution, and the possibility to correctly locate functional abnormalities (by the SPECT or PET component) within a definite anatomic field (by the CT component) [34].The γ-emitting radionuclides that are used for planar and SPECT imaging are usually obtained within hospital nuclear medicine facilities (or research departments) from small portable generators; some are produced by nuclear reactors and then shipped to the hospital facility ready to use. The β+ emitting radionuclides ...

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Radiolabeled theranostics: magnetic and gold nanoparticles

Cited by 80 publications

References 117 publications

One‐Step Synthesis of Dicyanobenzene‐Derived Nitrogen‐Doped Porous Carbon Monolayers: Porosity and Near‐infrared Photoactivity

One‐Step Synthesis of Dicyanobenzene‐Derived Nitrogen‐Doped Porous Carbon Monolayers: Porosity and Near‐infrared Photoactivity

Multimodal Magnetic-Plasmonic Nanoparticles for Biomedical Applications

Gold Nanoparticles and Nanorods in Nuclear Medicine: A Mini Review

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