Radiolabelling of engineered nanoparticles for in vitro and in vivo tracing applications using cyclotron accelerators

Gibson, P.N.; Holzwarth, Uwe; Abbas, K.; Simonelli, Federica; Kozempel, Ján; Cydzik, Izabela; Cotogno, Giulio; Bulgheroni, A.; Gilliland, Douglas; Ponti, Jessica; Franchini, Fabio; Marmorato, Patrick; Stamm, H.; Kreyling, Wolfgang G.; Wenk, Alexander; Semmler‐Behnke, Manuela; Buono, S.; Maciocco, Luca; Burgio, N.

doi:10.1007/s00204-011-0701-6

Cited by 66 publications

(112 citation statements)

References 82 publications

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“…However, newer studies show that internalized SPIO can influence the cell expression pattern (e. g. by oxidative stress), cell proliferation, and cell differentiation [55]. Methods for core labeling (e. g. 59 Fe [56]) and coating labeling with radioisotopes [57] (e. g. 111 In [61]. Headache or back pain, vasodilation, hypotension, or allergic reaction in the form of urticaria can occur on rare occasions [62].…”

Section: Distribution Degradation and Toxicitymentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Ittrich¹,

Peldschus²,

Raabe³

et al. 2013

Fortschr Röntgenstr

124

101

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Superparamagnetic iron oxide nanoparticles (SPIO) can be used to image physiological processes and anatomical, cellular and molecular changes in diseases. The clinical applications range from the imaging of tumors and metastases in the liver, spleen and bone marrow, the imaging of lymph nodes and the CNS, MRA and perfusion imaging to atherosclerotic plaque and thrombosis imaging. New experimental approaches in molecular imaging describe undirected SPIO trapping (passive targeting) in inflammation, tumors and associated macrophages as well as the directed accumulation of SPIO ligands (active targeting) in tumor endothelia and tumor cells, areas of apoptosis, infarction, inflammation and degeneration in cardiovascular and neurological diseases, in atherosclerotic plaques or thrombi. The labeling of stem or immune cells allows the visualization of cell therapies or transplant rejections. The coupling of SPIO to ligands, radio- and/or chemotherapeutics, embedding in carrier systems or activatable smart sensor probes and their externally controlled focusing (physical targeting) enable molecular tumor therapies or the imaging of metabolic and enzymatic processes. Monodisperse SPIO with defined physicochemical and pharmacodynamic properties may improve SPIO-based MRI in the future and as targeted probes in diagnostic magnetic resonance (DMR) using chip-based ?NMR may significantly expand the spectrum of in vitro analysis methods for biomarker, pathogens and tumor cells. Magnetic particle imaging (MPI) as a new imaging modality offers new applications for SPIO in cardiovascular, oncological, cellular and molecular diagnostics and therapy. Key Points: Citation Format:

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Section: Distribution Degradation and Toxicitymentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Ittrich¹,

Peldschus²,

Raabe³

et al. 2013

Fortschr Röntgenstr

124

101

View full text Add to dashboard Cite

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“…Among the different examples that could be used to explore the paradigm of unconventional radionuclides for PET imaging in analysis, 45 Ti is an interesting case study.…”

Section: Titanium-45 and Its Applicationsmentioning

confidence: 99%

“…Several examples of unconventional radionuclides for PET imaging are being suggested, and 45 Ti could be suggested as a model, due to its interesting properties such as its abundant positron emission (85%), reduced positron energy (β + endpoint energy = 1040 keV), physical half-life of 3.09 h, and interesting chemical properties. This review aims to introduce the role of cyclotrons in the production of unconventional radionuclides for PET imaging while using 45 Ti as an example to explore the potential biomedical applications of those radionuclides in PET imaging. …”

mentioning

confidence: 99%

Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications

et al. 2018

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Positron emitting radionuclides are used to label different compounds, allowing the study of the major biological systems using PET (positron emission tomography) imaging. Although there are several radionuclides suited for PET imaging, routine clinical applications are still based on a restrict group constituted by 18 F, 11 C, and, more recently, 68 Ga. However, with the enlarged availability of low-energy cyclotrons and technical improvements in radionuclide production, the use of unconventional radionuclides is progressively more common. Several examples of unconventional radionuclides for PET imaging are being suggested, and 45 Ti could be suggested as a model, due to its interesting properties such as its abundant positron emission (85%), reduced positron energy (β + endpoint energy = 1040 keV), physical half-life of 3.09 h, and interesting chemical properties. This review aims to introduce the role of cyclotrons in the production of unconventional radionuclides for PET imaging while using 45 Ti as an example to explore the potential biomedical applications of those radionuclides in PET imaging.

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“…The hydroxyl group in the p-position favours transporter-mediated uptake into cardiomyocytes. Moreover, isomerisation of synephrine influences its toxicological profile (49) Rossato et al (2011) DNA strand breaks induced by platinum nanoparticles are mediated by platinum ions released from the nanoparticles (50) Gehrke et al (2011) This review deals with the description and comparison of cyclotron-based irradiation techniques for the generation of radiolabelled nanoparticles applicable in nanotoxicity tracing approaches (51) Gibson et al (2011) In urinary bladder cancer, all known validated individual SNPs are associated with only a moderate risk that is too low to justify preventive measures. The authors review this issue and propose that these so-called wimp SNPs may interact and, therefore, collectively result in much higher risk with preventive relevance (52) Golka et al (2011) The genotoxic potential of dental composite components, such as bis-GMA, TEGDMA, HEMA and MMA, was studied in gingival fibroblasts.…”

Section: Key Messages Referencesmentioning

confidence: 99%

Nanotoxicology and oxidative stress control: cutting-edge topics in toxicology

2012

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Radiolabelling of engineered nanoparticles for in vitro and in vivo tracing applications using cyclotron accelerators

Cited by 66 publications

References 82 publications

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications

Nanotoxicology and oxidative stress control: cutting-edge topics in toxicology

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