Radiological and clinical spectrum of COVID-19: A major concern for public health

Verma, Henu Kumar

doi:10.4329/wjr.v13.i3.53

Cited by 9 publications

(9 citation statements)

References 74 publications

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“…The COVID-19 cases were defined as the combination of a positive RT-PCR for SARS-CoV-2 in a nasopharyngeal swab or in broncho-alveolar lavage specimens [ 15 ] and consistent abnormalities in chest X-rays or computed tomography [ 16 ]. Immunosuppression was defined as chronic immunosuppressive therapy including corticosteroids, human immunodeficiency virus infection, or malignant hemopathy.…”

Section: Methodsmentioning

confidence: 99%

Early Corticosteroid Therapy May Increase Ventilator-Associated Lower Respiratory Tract Infection in Critically Ill Patients with COVID-19: A Multicenter Retrospective Cohort Study

et al. 2022

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Background: The coronavirus disease 2019 (COVID-19) pandemic has put significant pressure on hospitals and in particular on intensive care units (ICU). Some patients develop acute hypoxemic respiratory failure with profound hypoxia, which likely requires invasive mechanical ventilation during prolonged periods. Corticosteroids have become a cornerstone therapy for patients with severe COVID-19, though only little data are available regarding their potential harms and benefits, especially concerning the risk of a ventilator-associated lower respiratory tract infection (VA-LRTI). Methods: This retrospective multicenter study included patients admitted in four ICUs from Belgium and France for severe COVID-19, who required invasive mechanical ventilation (MV). We compared clinical and demographic variables between patients that received corticosteroids or not, using univariate, multivariate, and Fine and Gray analyses to identify factors influencing VA-LRTI occurrence. Results: From March 2020 to January 2021, 341 patients required MV for acute respiratory failure related to COVID-19, 322 of whom were included in the analysis, with 60.6% of them receiving corticosteroids. The proportion of VA-LRTI was significantly higher in the early corticosteroid group (63.1% vs. 48.8%, p = 0.011). Multivariable Fine and Gray modeling considering death and extubation as competing events revealed that the factors independently associated with VA-LRTI occurrence were male gender (adjusted sHR:1.7, p = 0.0022) and corticosteroids (adjusted sHR: 1.44, p = 0.022). Conclusions: in our multicenter retrospective cohort of COVID-19 patients undergoing MV, early corticosteroid therapy was independently associated with VA-LRTI.

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Section: Methodsmentioning

confidence: 99%

Early Corticosteroid Therapy May Increase Ventilator-Associated Lower Respiratory Tract Infection in Critically Ill Patients with COVID-19: A Multicenter Retrospective Cohort Study

et al. 2022

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“…In the case of MERS and SARS-CoV-2, abnormal chest Xrays are found in approximately 90% of patients. [102][103][104] However, few abnormal chest X-rays have been reported during the early stages of COVID-19 104 ; although, it is worth mentioning that patients with severe infection can rapidly progress to ARDS and shock. In SARS, abnormal chest X-rays are less common, i.e., 50 to 70% of patients.…”

Section: Severe Lrvi Due To Coronavirusesmentioning

confidence: 99%

Severe Infections Due to Respiratory Viruses

Cillóniz

Pericàs

Rojas

2022

Semin Respir Crit Care Med

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Severe viral infections may result in severe illnesses capable of causing acute respiratory failure that could progress rapidly to acute respiratory distress syndrome (ARDS), related to worse outcomes, especially in individuals with a higher risk of infection, including the elderly and those with comorbidities such as asthma, diabetes mellitus and chronic respiratory or cardiovascular disease. In addition, in cases of severe viral pneumonia, co-infection with bacteria such as Streptococcus pneumoniae and Staphylococcus aureus is related to worse outcomes. Respiratory viruses like influenza, rhinovirus, parainfluenza, adenovirus, metapneumovirus, respiratory syncytial virus, and coronavirus have increasingly been detected. This trend has become more prevalent, especially in critically ill patients, due to the availability and implementation of molecular assays in clinical practice. Respiratory viruses have been diagnosed as a frequent cause of severe pneumonia, including cases of community-acquired pneumonia, hospital-acquired pneumonia, and ventilator-associated pneumonia. In this review, we will discuss the epidemiology, diagnosis, clinical characteristics, management, and prognosis of patients with severe infections due to respiratory viruses, with a focus on influenza viruses, non-influenza viruses, and coronaviruses.

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“…The initial positive nucleic acid test and the lung changes seen on computed tomography (CT) scans must be compared and checked. Positive cases typically have a low lung CT, which is similar to a reverse halo sign, but this should be supported by several other nucleic acid tests [ 31 , 32 ].…”

Section: Current Diagnostic Tests For Covid-19mentioning

confidence: 99%

Rapid diagnostic methods for SARS-CoV-2 (COVID-19) detection: an evidence-based report

Verma

Sharma

Verma³

et al. 2021

JMedLife

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Since December 2019, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been a global health concern. The transmission method is human-to-human. Since this second wave of SARS-CoV-2 is more aggressive than the first wave, rapid testing is warranted to use practical diagnostics to break the transfer chain. Currently, various techniques are used to diagnose SARS-CoV-2 infection, each with its own set of advantages and disadvantages. A full review of online databases such as PubMed, EMBASE, Web of Science, and Google Scholar was analyzed to identify relevant articles focusing on SARS-CoV-2 and diagnosis and therapeutics. The most recent article search was on May 10, 2021. We summarize promising methods for detecting the novel Coronavirus using sensor-based diagnostic technologies that are sensitive, cost-effective, and simple to use at the point of care. This includes loop-mediated isothermal amplification and several laboratory protocols for confirming suspected 2019-nCoV cases, as well as studies with non-commercial laboratory protocols based on real-time reverse transcription-polymerase chain reaction and a field-effect transistor-based bio-sensing device. We discuss a potential discovery that could lead to the mass and targeted SARS-CoV-2 detection needed to manage the COVID-19 pandemic through infection succession and timely therapy.

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Radiological and clinical spectrum of COVID-19: A major concern for public health

Cited by 9 publications

References 74 publications

Early Corticosteroid Therapy May Increase Ventilator-Associated Lower Respiratory Tract Infection in Critically Ill Patients with COVID-19: A Multicenter Retrospective Cohort Study

Early Corticosteroid Therapy May Increase Ventilator-Associated Lower Respiratory Tract Infection in Critically Ill Patients with COVID-19: A Multicenter Retrospective Cohort Study

Severe Infections Due to Respiratory Viruses

Rapid diagnostic methods for SARS-CoV-2 (COVID-19) detection: an evidence-based report

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