Radiological features of pulmonary tuberculosis in 963 HIV-infected adults at three Central African Hospitals

Tshibwabwa-Tumba, E; Mwinga, Alwyn; Pobee, J. O. M.; Zumla, Alimuddin

doi:10.1016/s0009-9260(97)80078-5

Cited by 33 publications

(17 citation statements)

References 12 publications

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“…(7,14,15,23) We identified nodules in 16.3% of the cases. In one study, (15) X-rays revealed nodules in only 1.3% of tuberculosis patients co-infected with HIV.…”

Section: Discussionmentioning

confidence: 91%

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Manifestações clínicas, radiológicas e laboratoriais em indivíduos com tuberculose pulmonar: estudo comparativo entre indivíduos HIV positivos e HIV negativos internados em um hospital de referência

2011

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Objective: To compare clinical, radiological, and laboratory characteristics of individuals with pulmonary tuberculosis co-infected or not with HIV. Methods: A cross-sectional study, in which signs and symptoms were assessed by anamnesis and physical examination in patients hospitalized with pulmonary tuberculosis. The results of sputum smear microscopy and culture for Mycobacterium tuberculosis, as well as hemoglobin levels and CD4 + T-cell counts, were obtained from medical records, and chest X-ray reports were consulted. Results: We included 50 pulmonary tuberculosis patients, who were divided into two groups (HIV-positive and HIV-negative; n = 25 per group). The mean age of the participants was 38.4 ± 10.5 years; 46 (92%) were males; and 27 (54%) were White. Expectoration was presented by 21 (84%) and 13 (52%) of the patients in the HIV-negative and HIV-positive groups, respectively (p = 0.016). Radiological findings of cavitation were present in 10 (43%) and 2 (10%) of the patients in the HIV-negative and HIV-positive groups, respectively (p = 0.016), whereas an interstitial pattern was observed in 18 (78%) and 8 (40%), respectively (p = 0.012). The mean hemoglobin level was 11.1 ± 2.9 g/ dL and 9.3 ± 2.2 g/dL in the HIV-negative and HIV-positive groups, respectively (p = 0.015). Conclusions: In our sample of tuberculosis patients, expectoration was less prevalent, hemoglobin levels were lower, and cavitation was less common, as was an interstitial pattern, among those co-infected with HIV than among those without HIV co-infection.Keywords: HIV; Tuberculosis; Acquired immunodeficiency syndrome. ResumoObjetivo: Comparar as manifestações clínicas, radiológicas e laboratoriais de indivíduos com tuberculose pulmonar coinfectados com HIV com aqueles sem a coinfecção. Métodos: Estudo transversal, no qual sinais e sintomas foram analisados por meio de anamnese e exame físico em pacientes internados com tuberculose pulmonar. A baciloscopia, a cultura para Mycobacterium tuberculosis, a dosagem de hemoglobina e a contagem de células T CD4 + foram obtidas de registros dos prontuários, assim como os laudos das radiografias de tórax. Resultados: Foram incluídos 50 pacientes com tuberculose pulmonar, que foram divididos em dois grupos (HIV positivo e HIV negativo; n = 25 por grupo). A média de idade dos participantes foi de 38,4 ± 10,5 anos, 46 (92%) eram do sexo masculino, e 27 (54%) eram caucasianos. Apresentaram expectoração 21 (84%) e 13 (52%) dos pacientes nos grupos HIV negativo e HIV positivo, respectivamente (p = 0,016). Achados radiológicos de cavitação estavam presentes em 10 (43%) e 2 (10%) dos pacientes nos grupos HIV negativo e HIV positivo, respectivamente (p = 0,016), ao passo que padrão intersticial estava presente em 18 (78%) e 8 (40%) dos pacientes nesses grupos (p = 0,012). O nível médio de hemoglobina foi de 11,1 ± 2,9 g/dL e 9,3 ± 2,2 g/dL nos grupos HIV negativo e HIV positivo, respectivamente (p = 0,015). Conclusões: Entre pacientes coinfectados com tuberculose e HIV desta amostra, houve me...

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“…(7,14,15,23) We identified nodules in 16.3% of the cases. In one study, (15) X-rays revealed nodules in only 1.3% of tuberculosis patients co-infected with HIV.…”

Section: Discussionmentioning

confidence: 91%

“…One group of authors (23) found that the prevalence of pleural effusion among HIV-positive and HIV-negative patients was 16.0% and 6.8%, respectively (p < 0.001).…”

Section: Discussionmentioning

confidence: 99%

Manifestações clínicas, radiológicas e laboratoriais em indivíduos com tuberculose pulmonar: estudo comparativo entre indivíduos HIV positivos e HIV negativos internados em um hospital de referência

2011

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“…In a study comparing 963 HIV positive adults with pulmonary TB with 1000 HIV negative age-matched controls, there was a significantly higher incidence of pleural effusions (16 vs. 6.8 %) [21]. In the western world, a study in South Carolina, USA appeared to show increased rates of pleural TB in AIDS cases (11 %) compared to non-AIDS cases (6 %) [22].…”

Section: Discussionmentioning

confidence: 99%

“…A study from Tanzania found that HIV positive patients tend to present with more constitutional symptoms such as dyspnoea, fevers, night sweats, Treatment of tuberculous pleurisy in HIV positive co-infection is generally successful with a good outcome in most cases. In a series of 22 patients, there were 2 deaths reported and only 1 after antituberculous chemotherapy was commenced [21]. The current study's main focus is on pleurisy TB (EPTB) but comparison was made with PTB, to get a clear picture based on treatment outcomes.…”

Section: Discussionmentioning

confidence: 99%

Pleural Tuberculosis and its Treatment Outcomes

Khan¹,

Sulaiman²,

Muttalif³

et al. 2013

Trop. J. Pharm Res

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“…[1] Currently, there is a lack of access to health care with only 0.11 general practitioners per 1 000 individuals. [2] According to 2011 data polling Indonesian primary care physicians, sonography is offered by less than 50% of general practitioners in the country.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a point of care ultrasound curriculum for Indonesian physicians taught by first-year medical students

Lee¹,

Tse²,

Keown³

et al. 2017

World Journal of Emergency Medicine

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BACKGROUND:The purpose of this study was to assess the short-term effi cacy of a 4-week ultrasound curriculum taught by American fi rst-year medical students to general practitioners working in public health care clinics, or puskesmas, in Bandung, Indonesia. METHODS:We performed a prospective, observational study of Indonesian health care practitioners from public clinics in Bandung, Indonesia. These practitioners were enrolled in a 4-week ultrasound training course taught by first-year American medical students. A total of six sessions were held comprising of 38 ultrasound milestones. A pre-course and post-course written exam and practical exam was taken by each participant. RESULTS:We enrolled 41 clinicians in the course. The average pre-course exam score was 35.2% with a 2.4% pass rate, whereas the average post-course exam score was 82.0% with a 92.7% pass rate. The average practical score at the completion of the course was 83.2% (SD=0.145) with 82.9% of the class passing (score above 75.0%). CONCLUSION:Our data suggests that first-year medical students can effectively teach ultrasound to physicians in Indonesia using a 4-week intensive ultrasound training course. Future studies are needed to determine the amount of training required for profi ciency and to evaluate the physicians' perceptions of the student-instructors' depth of knowledge and skill in point of care ultrasound.

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Radiological features of pulmonary tuberculosis in 963 HIV-infected adults at three Central African Hospitals

Cited by 33 publications

References 12 publications

Manifestações clínicas, radiológicas e laboratoriais em indivíduos com tuberculose pulmonar: estudo comparativo entre indivíduos HIV positivos e HIV negativos internados em um hospital de referência

Manifestações clínicas, radiológicas e laboratoriais em indivíduos com tuberculose pulmonar: estudo comparativo entre indivíduos HIV positivos e HIV negativos internados em um hospital de referência

Pleural Tuberculosis and its Treatment Outcomes

Evaluation of a point of care ultrasound curriculum for Indonesian physicians taught by first-year medical students

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