Radiological imaging features of glioblastoma with oligodendroglioma component: a comparison with conventional glioblastoma

Kanoto, Masafumi; Kirii, Kazukuni; Toyoguchi, Yuuki; Nishihara, Masashi; Sakurai, Keita; Murayama, Kazuhiro; Noguchi, Tomoyuki; Matsuda, Keigo; Sakurada, Kaori; Sonoda, Yukihiko; Hosoya, Takamitsu

doi:10.1177/2058460116675191

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…On MRI, GBM is seen as a contrast-enhancing lesion with central necrosis surrounded by T 2 /FLAIR hyperintense regions representing a combination of perilesional edema and infiltrating tumor cells. 2 Despite extensive research on optimizing treatment strategies, patient outcome is unfavorable with a median survival of 15 months. 3 In posttreatment settings, tumor recurrence is observed very often.…”

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confidence: 99%

Quantification of perineural satellitosis in pretreatment glioblastoma with structural MRI and a diffusion tensor imaging template

van den Elshout,

Ariëns,

Blaauboer

et al. 2023

Neuro-Oncology Advances

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Background Survival outcomes for glioblastoma (GBM) patients remain unfavorable, and tumor recurrence is often observed. Understanding the radiological growth patterns of GBM could aid in improving outcome. This study aimed to examine the relationship between contrast-enhancing tumor growth direction and white matter, using an image registration and deformation strategy. Methods In GBM patients two pretreatment scans (diagnostic and neuronavigation) were gathered retrospectively, co-registered to a template and DTI atlas. The GBM lesions were segmented and co-registered to the same space. Growth vectors were derived and divided into vector populations parallel (Φ = 0-20 degrees) and perpendicular (Φ = 70-90 degrees) to white matter. To test for statistical significance between parallel and perpendicular groups, a paired samples Students T-test was performed. O6-methylguanine-DNA methyltransferase (MGMT) methylation status and its correlation to growth rate was also tested using a one-way ANOVA test. Results For 78 GBM patients (mean age 61 years ± 13 SD, 32 men), the included GBM lesions showed a predominant preference of perineural satellitosis (p<0.001), with a mean percentile growth of 30.8% (95CI 29.6% – 32.0%) parallel (0° < |Φ| <20°) to white matter. Perpendicular tumor growth with respect to white matter microstructure (70° < |Φ| <90°) showed to be 22.7% (95CI 21.3% – 24.1%) of total tumor growth direction. Conclusions The presented strategy showed that tumor growth direction in pretreatment GBM patients correlated with white matter architecture. Future studies with patient-specific DTI data are required to verify the accuracy of this method prospectively to identify its usefulness as a clinical metric in pre- and posttreatment setting.

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confidence: 99%

Quantification of perineural satellitosis in pretreatment glioblastoma with structural MRI and a diffusion tensor imaging template

van den Elshout,

Ariëns,

Blaauboer

et al. 2023

Neuro-Oncology Advances

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“…Moreover, comparison of radiological imaging features may discriminate GBMO from conventional GBM (i.e. WHO grade IV) [119].…”

Section: Methylation Of Mgmt Genes In Oligodendrogliomasmentioning

confidence: 99%

Differential mRNA and miRNA expression in oligodendrogliomas of different grades of malignancy

Nawaz¹

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All praise to Allah Almighty, the most beneficent, the most merciful, Who honoured man with intellectual power and spiritual insight to understand, discover and to conquer wondrous mysteries. Countless salutations upon the Holy Prophet Muhammad (peace be upon him), for enlightening humanity with the essence of faith and guiding the mankind to the true path of life. I would like to express my profound gratitude to all those who helped me in different ways during my PhD. In particular I am rather indebted to thank; Luciano Neder: PhD supervisor, for giving me opportunity to work in his group. His kind supervision, guidance, and personal interests in my research work made this all possible. What most profoundly I recognize is that, he gave me freedom, letting me doing things independently with my own ideas and decisions. I took advantage of this freedom for writing fellowship applications independently, travel grants for participating in conferences and writing up scientific articles. Collectively this all made my way to academic growth as an independent researcher. I have really enjoyed our chats and gossips not only about science, but about everything in life; family, culture and social norms across the borders. Many thanks for your support through difficult circumstances that had arisen throughout my stay at Ribeirao Preto. I really had an amazing time with you. Hadi Valadi: my co-supervisor, who proved to be one of the productive additions in my scientific career. It was a great experience being at Gothenburg and enjoying exosomes science in his lab at Sahlgrenska Academy. He provided me the facilities of the lab in a proper, suitable and helping manner and this was the first time I gained very authoritative knowledge about newly described area of exosomes research. This is safe to say that, it will come in very useful way in my future career. Last, but not least, my affiliations with him recognize his patronizing concerns towards scientific goals. There was so much to learn from you. I thank Tao Jin at the Department of Rheumatology and Inflammation Research at Sahlgrenska Academy for his cooperation and support. And "wow" all those guys at department lunch room with whom I have had company during lunch time.

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Radiological imaging features of glioblastoma with oligodendroglioma component: a comparison with conventional glioblastoma

Cited by 2 publications

References 22 publications

Quantification of perineural satellitosis in pretreatment glioblastoma with structural MRI and a diffusion tensor imaging template

Quantification of perineural satellitosis in pretreatment glioblastoma with structural MRI and a diffusion tensor imaging template

Differential mRNA and miRNA expression in oligodendrogliomas of different grades of malignancy

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