Radionuclides: Applications in Diagnostic and Therapeutic Nuclear Medicine

Cerebral Accumulation of TC-99M Ethyl Cysteinate Dimer (ECD) in Severe, Transient Hypothyroidism

“…Ethyl cysteinate dimer, because of its high lipophilicity, passes through the blood-brain barrier via the endothelial cell membrane (Weiner and Thakur, 2003). On entrance into the cellular space, metabolism to one or more polar Tc-99m-complexes occurs via enzymatic deesterification, with this process being directly affected by the location of the esterase activity (i.e., membrane bound versus free in the cytosol) (Verbruggen, 1998;JacquierSarlin et al, 1996).…”

Production of111In from an In/In2O3target

“…It decays with a half-life of 2.83 days by 100% electron capture, yielding two γ -rays of 171.3 keV and 245.4 keV [1][2][3]. Several routes for its production are employed, the most popular method being proton and deuteron bombardment of nat Cd or an enriched Cd isotope [4,5]. 111 In is important for clinical application, especially as a tracer in the human body for in vivo studies, for which observation periods of several days are required [4,6].…”

“…Several routes for its production are employed, the most popular method being proton and deuteron bombardment of nat Cd or an enriched Cd isotope [4,5]. 111 In is important for clinical application, especially as a tracer in the human body for in vivo studies, for which observation periods of several days are required [4,6]. This is due to the fact that 111 In has a favourable half-life and a high yield of γ -rays with energies in the optimum range of detectability of commercially available SPECT imaging devices, together with the absence of undesirable β-emission.…”

Estudo compartimental e dosimétrico do anti-CD20 marcado com ¹⁸⁸Re

“…Utilizando um sistema de gerador, é possível obter um radionuclídeo filho com uma pureza radioquímica adequada mediante adaptação de uma técnica de separação adequada e eficiente [HORTON, 1982]. [ZALUTSKY et al, 2007;DEARLING & PEDLEY, 2007].…”

“…16) [ZALUTSKY et al, 2007]. A partícula  produzida pelo decaimento do 211 At possui uma energia média de 6,7 MeV (41,8%) e um LET médio de 97-99 keV/m.…”