Radiopaque Resorbable Inferior Vena Cava Filter Infused with Gold Nanoparticles

Tian, Li; Lee, Patrick; Singhana, Burapol; Chen, Aaron; Qiao, Yanjiang; Lu, Linfeng; Martinez, Jonathan O.; Tasciotti, Ennio; Melancon, Adam David; Huang, Steven Y.; Eggers, M.; Melancon, Marites P.

doi:10.1038/s41598-017-02508-3

Cited by 20 publications

(25 citation statements)

References 26 publications

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“…TEM and UV-Vis spectrum of 4-nm AuNPs. The transmission electron microscopy (TEM) result (A) is consistent with the ~520 nm peak (shown by the arrow) on the UV-Vis spectrum (B) for the 4-nm AuNPs [4].…”

Section: Figuresupporting

confidence: 54%

“…In terms of in vitro cytotoxicity, no cytotoxicity was observed (one-way ANOVA, p<0.05) when evaluated on immortalized human vascular endothelial cell RF24 cells and normal lung fibroblast MRC5. This suggests that no significant difference in cell viability among the treatment groups, or between the treatment groups and the control group (one-way ANOVA, p<0.05) (Figure 3) [4].…”

Section: Resultsmentioning

confidence: 99%

“…The clinical implication is to avoid fatal complications associated with failure of retrieval of temporary IVCF. Our previous research has successfully demonstrated the feasibility of radiopacity enhancement by infusing iodine and gold nanoparticles (AuNPs) into PPDO [4, 5]. Our current research continues to investigate the enhanced material discrimination of AuNPs compared to iodine on dual energy CT (DECT) and the impact of AuNP infusion on in vivo imaging and behavior of PPDO IVCF.…”

Section: Introductionmentioning

confidence: 99%

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In vivo imaging of radiopaque resorbable inferior vena cava filter infused with gold nanoparticles

Tian

Lee

Singhana

et al. 2018

Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling

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Radiopaque resorbable inferior vena cava filter (IVCF) were developed to offer a less expensive alternative to assessing filter integrity in preventing pulmonary embolism for the recommended prophylactic period and then simply vanishes without intervention. In this study, we determined the efficacy of gold nanoparticle (AuNP)-infused poly-p-dioxanone (PPDO) as an IVCF in a swine model. Infusion into PPDO loaded 1.14±0.08 % AuNP by weight as determined by elemental analysis. The infusion did not alter PPDO’s mechanical strength nor crystallinity (Kruskal−Wallis one-way ANOVA, p<0.05). There was no cytotoxicity observed (one-way ANOVA, p<0.05) when tested against RF24 and MRC5 cells. Gold content in PPDO was maintained at ~2000 ppm during the 6-week incubation in PBS at 37°C. As a proof-of-concept, two pigs were deployed with IVCF, one with AuNP-PPDO and the other without coating. Results show that the stent ring of AuNP-PPDO was highly visible even in the presence of iodine-based contrast agent and after clot introduction, but not of the uncoated IVCF. Autopsy at two weeks post-implantation showed AuNP-PPDO filter was endothelialized onto the IVC wall, and no sign of filter migration was observed. The induced clot was also still trapped within the AuNP-PPDO IVCF. As a conclusion, we successfully fabricated AuNP-infused PPDO IVCF that is radiopaque, has robust mechanical strength, biocompatible, and can be imaged effectively in vivo. This suggests the efficacy of this novel, radiopaque, absorbable IVCF for monitoring its position and integrity over time, thus increasing the safety and efficacy of deep vein thrombosis treatment.

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Section: Figuresupporting

confidence: 54%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vivo imaging of radiopaque resorbable inferior vena cava filter infused with gold nanoparticles

Tian

Lee

Singhana

et al. 2018

Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling

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“…We further improved the contrast agent by using 2- and 4-nm hydrophobic gold nanoparticles. Due to the higher Z number of gold, the radiopacity was even stronger than iodine infused PPDO, and the gold content and radiopacity remained stable over 6 weeks, which is the expected dwell time of the temporary ICVF 101 ( Fig. 8 ).…”

Section: Radiopaque Nanoparticles and Biomaterials For Atherosclerosimentioning

confidence: 81%

“…Our group recently engaged in the development of radiopaque and resorbable infera vena cava filters (IVCFs) 100 , 101 . IVCFs are indicated for at-risk patients who are contraindicated with anticoagulants.…”

Section: Radiopaque Nanoparticles and Biomaterials For Atherosclerosimentioning

confidence: 99%

Radiopaque nano and polymeric materials for atherosclerosis imaging, embolization and other catheterization procedures

Tian

Feng

et al. 2018

Acta Pharmaceutica Sinica B

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A review of radiopaque nano and polymeric materials for atherosclerosis imaging and catheterization procedures is presented in this paper. Cardiovascular diseases (CVDs) are the leading cause of death in the US with atherosclerosis as a significant contributor for mortality and morbidity. In this review paper, we discussed the physics of radiopacity and X-ray/CT, clinically used contrast agents, and the recent progress in the development of radiopaque imaging agents and devices for the diagnosis and treatment of CVDs. We focused on radiopaque imaging agents for atherosclerosis, radiopaque embolic agents and drug eluting beads, and other radiopaque medical devices related to catheterization procedures to treat CVDs. Common strategies of introducing radiopacity in the polymers, together with examples of their applications in imaging and medical devices, are also presented.

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Optimization of the differentiation and quantification of high‐Z nanoparticles incorporated in medical devices for CT‐guided interventions

et al. 2020

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Purpose Material differentiation has been made possible using dual‐energy computed tomography (DECT), in which the unique, energy‐dependent attenuating characteristics of materials can provide new diagnostic information. One promising application is the clinical integration of biodegradable polymers as temporary implantable medical devices impregnated with high‐atomic number (high‐Z) materials. The purpose of this study was to explore the incorporation of high atomic number (high‐Z) contrast materials in a bioresorbable inferior vena cava filter for advanced CT‐based monitoring of its location and differentiating from surrounding materials. Materials and methods Imaging optimization and calibration studies were performed using a body phantom. The dual‐energy CT (DECT) ratios for iron, zirconium, barium, gadolinium, ytterbium, tantalum, tungsten, gold, and bismuth were generated for peak kilovoltage combinations of 80/150Sn, 90/150Sn, and 100/150Sn kVp in dual‐source CT via linear regression of the CT numbers at low and high energies. A secondary calibration of the material map to the nominal material concentration was generated to correct for use of materials other than iodine. CT number was calibrated to the material concentration based on single‐energy CT (SECT) with additional filtration (150Sn kVp). These quantification methods were applied to monitoring of biodegradable inferior vena cava filters (IVCFs) made of braided poly(p‐dioxanone) sutures infused with ultrasmall bismuth nanoparticles (BiNPs) implanted in an adult domestic pig. Results Qualitative material differentiation was optimal for high‐Z (>73) contrast agents in DECT. However, quantification became nonlinear and inaccurate as the K‐edge of the material increased. Using the high‐energy (150Sn kVp) data component as a SECT scan, the linearity of quantification curves was maintained with lower limits of detection than with DECT. Among the materials tested, bismuth had optimal differentiation from iodine in DECT while maintaining increased contrast in high‐energy SECT for quantification (11.5% error). Coating the IVCF with BiNPs resulted in markedly greater radiopacity (maximum CT number, 2028 HU) than that of an uncoated IVCF (maximum CT number, 127 HU). Using DECT imaging and processing, the BiNP‐IVCF could be clearly differentiated from iodine contrast injected into the inferior vena cava of the pig. Conclusions These findings may improve widespread integration of medical devices incorporated with high‐Z materials into the clinic, where technical success, possible complications, and device integrity can be assessed intraoperatively and postoperatively via DECT imaging.

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Radiopaque Resorbable Inferior Vena Cava Filter Infused with Gold Nanoparticles

Cited by 20 publications

References 26 publications

In vivo imaging of radiopaque resorbable inferior vena cava filter infused with gold nanoparticles

In vivo imaging of radiopaque resorbable inferior vena cava filter infused with gold nanoparticles

Radiopaque nano and polymeric materials for atherosclerosis imaging, embolization and other catheterization procedures

Optimization of the differentiation and quantification of high‐Z nanoparticles incorporated in medical devices for CT‐guided interventions

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