Radioprotection by two phenolic compounds: Chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro

Çinkılıç, Nilüfer; Çetintaş, Sibel Kahraman; Zorlu, Tolga; Vatan, Özgür; Yılmaz, Dilek Demirezen; Çavaş, Tolga; Tunç, Sema; Özkan, Lütfi; Bilaloĝlu, Rahmi

doi:10.1016/j.fct.2012.12.008

Cited by 120 publications

(86 citation statements)

References 38 publications

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“…16,39) CGA, a natural phenolic compound found in human diet, has been reported to exhibit potent antioxidant and antiinflammatory activities. [18][19][20][21]40) Hypoglycemic effects of CGA has been shown in diabetic rats. 23,41) CGA may have particularly beneficial effects on healing as a result of its properties.…”

Section: Discussionmentioning

confidence: 99%

“…CGA has strong anti-inflammatory and antioxidant activities. [18][19][20][21] While the exact mechanisms for VEGF expression process are unclear, these activities may involve in it for flap tissue healing. The mechanisms in the effect of CGA on VEGF expression in different situations need further examinations.…”

Section: Fig 4 Regional Blood Perfusion In the Skin Flapsmentioning

confidence: 99%

“…[19][20][21][22][23][24] Experimentally, CGA has been reported to exhibit free-radical scavenging and antagonistic effects against lipid peroxidation in different organs. 11,22,25,26) The effects of topical CGA treatment on an excisional wound model have been investigated recently.…”

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confidence: 99%

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Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats

Bağdaş

Etoz

Inan

et al. 2014

Biological & Pharmaceutical Bulletin

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There has been considerable interest in understanding the effects of antioxidants in flap survival during diabetes. Previous studies showed that chlorogenic acid (CGA) exhibits potent antioxidant effects. We aimed to determine the effects of systemic CGA treatment on skin flap survival in an experimental random-pattern dorsal skin flap model in diabetic rats. Twenty-eight male Wistar rats were divided into four groups: phosphate buffered saline (PBS)-treated or CGA-treated nondiabetic rats, PBS-treated or CGA-treated diabetic rats. Diabetes was induced by streptozotocin (45 mg/kg). Caudally based bipedicled dorsal skin flaps were elevated. CGA (100 mg/kg) or PBS (mL/kg; as vehicle) was administered intraperitoneally once daily. On postoperative day 7, flap survival, regional blood perfusion and microangiography were evaluated. The malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and nitric oxide (NO) levels were evaluated from the flap tissue. Capillary density and vascular endothelial growth factor (VEGF) expression were assessed. Harmful effects of diabetes on flap survival were observed. CGA attenuated these effects and allowed greater survival and blood perfusion. CGA decreased MDA and NO levels and increased GSH and SOD levels. CGA elevated capillary density and VEGF expression. This study showed that peripherally administered CGA significantly improved flap survival in diabetic and nondiabetic rats.Key words antioxidant; chlorogenic acid; diabetes; dorsal skin flap; flap survival; oxidative stress Skin flaps are widely used in the repair of local tissue loss and the reconstruction of several tissue defects. Flap necrosis is frequently observed in flap tissues in the postoperative period and is an unwanted effect of healing. Many factors are known to play a role in this major complication such as ischemia, inadequate blood flow and disturbed venous drainage.

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Section: Discussionmentioning

confidence: 99%

Section: Fig 4 Regional Blood Perfusion In the Skin Flapsmentioning

confidence: 99%

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Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats

Bağdaş

Etoz

Inan

et al. 2014

Biological & Pharmaceutical Bulletin

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“…Chlorogenic acid was the major component of the identified phenolic compounds in all tested pear cultivars. Chlorogenic acid has properties that are beneficial for human health: besides antioxidant activity [35] and an anti-inflammatory effect [36], it lowers the risk of type II diabetes mellitus [37], improves cardiac and vascular function [38], and inhibits carcinogenesis processes [39,40]. Other scientists [41,42] also have detected chlorogenic acid in pear fruit.…”

Section: Identification Of Phenolic Compounds In the Analysedmentioning

confidence: 99%

Determination of the Phenolic Composition and Antioxidant Activity of Pear Extracts

Liaudanskas

Zymonė

Viškelis

et al. 2017

Journal of Chemistry

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The specific HPLC analytical procedure was developed and validated for the determination of phenolic compounds in pear samples of different popular cultivars "Conference," "Concordia," "Grabova," and "Patten." HPLC mobile phase consisted of 0.05% (v/v) trifluoroacetic acid in water and 100% (v/v) acetonitrile. The HPLC method was used to identify and confirm the specificity of 8 analytes: chlorogenic acid, rutin, hyperoside, isoquercitrin, isorhamnetin rutinoside, quercitrin, quercitrin malonyl glucoside, and isorhamnetin glucoside. Repeatability % RSD did not exceed 3.87%, and intermediate precision did not exceed 4.63%. The total content of phenolic compounds varied from 0.51 ± 0.001 mg/g (cv. "Concordia") to 1.11 ± 0.013 mg/g (cv. "Patten"). Chlorogenic acid was the major component in all the tested pear cultivars. The highest amount of chlorogenic acid (0.69±0.033 mg/g) was found in pear samples of the cultivar "Grabova," and the highest amount of flavonol compounds (1.11 ± 0.013 mg/g) was found in pear samples of the cultivar "Concordia."

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“…Although some radio-protective drugs like amifostine [2,3] and genistein [4] are available, they have some unfavorable properties, for example amifostine has a short plasma lifetime, so has to administer every day [5], causes emesis [6], and wrong concentration of these drugs can increase the damage caused by ROS to the cells. Some phenolic acids (quinic acid and chlorogenic acid) have been assessed for their protective ability against radiation-induced DNA damage [7], but it's crucial to find natural source of radio-protective compounds such as dragon's blood (DB) and its extract to minimize radiation havocs by its phenolic compounds.…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of dragon’s blood resin extract as radio-protective agent

Mahmood¹,

Fatima²,

Zulfaqar³

et al. 2017

JCLM

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Radioprotection by two phenolic compounds: Chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro

Cited by 120 publications

References 38 publications

Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats

Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats

Determination of the Phenolic Composition and Antioxidant Activity of Pear Extracts

Meta-analysis of dragon’s blood resin extract as radio-protective agent

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