Radiotherapy for Isolated Increases in Serum Prostate-Specific Antigen Levels After Radical Prostatectomy

Pathologic seminal vesicle invasion after radical prostatectomy for patients with prostate carcinoma

“…[21][22][23] These studies antedated the use of PSA monitoring and relied on local recurdistant metastases in these men may have yielded less favorable outcomes. 6,7,19,24 In agreement with these rence or distant metastases as endpoints of treatment failure. More recently, it has become unclear whether studies, we found that men with SVI who had a persistently elevated PSA level had poor prognoses: the 3-pathologic SVI is an independent predictor of overall poor prognosis or an elevation of postoperative PSA and 4-year bNED rates for these men were 36% and 20%, respectively.…”

“…In contrast, Schild et al were unable to show a significant im-64 Gy or more to the prostatic bed were associated with better responses. 6 Another study confirmed the provement in bNED in men irradiated postoperatively for tumors involving the seminal vesicles. …”

“…The characteristics of the patients are listed in Table Radiation Therapy Thirty-three men received postoperative RT within 6 1. The clinical stages of the study population were T1c, T2, and T3 for 50%, 47%, and 3%, respectively.…”

Adjuvant Radiation Therapy following Radical Prostatectomy for Pathologic Stage C Prostate Cancer

“…bed before the PSA reaches 1.1 ng/ml [1,2]. This ap proach also has the advantage of sparing patients who would not benefit from adjuvant radiation therapy, such as those with no evident disease following surgery or those who have already developed a distant recurrence.…”

Conceptual design of a compact positron tomograph for prostate imaging

“…Treatment usually consists of radical prostatectomy, external beam irradiation, brachytherapy (interstitial implantation of radioactive seeds), androgen ablation (hormone) therapy, or "watchful waiting". In some cases, radiation therapy is prescribed to the pelvis and/or prostate bed even without confirmation by biopsy or imaging [5][6][7], despite the fact that irradiating a wide field in the pelvis (when disease is only suspected to extend beyond the known cancerous prostate) can lead to a higher incidence of post-irradiation morbidity than with irradiation of the prostate bed alone [8]. A major problem with prostatic cancer therapy is the question of when to treat or whether to treat at all.…”