Radiotherapy for recurrent choroidal neovascularisation complicating age related macular degeneration

Radiotherapy for age-related macular degeneration: no more pilot studies please

“…Presently, the stereotactic irradiation technique utilising a three-dimensional stereotactic system seems most promising in achieving a more precise delivery of higher radiation doses to the macula. Also, recent studies using larger fraction sizes of 3 Gy for recurrent CNV 47 have had promising short-term results and support further investigations using 4 Gy or higher fractions. Some of the most tantalizing results have been achieved with single doses of 14 Gy delivered with a proton beam 48 and suggest stability of visual acuity in some patients over a period of years as compared with only 8 Gy.…”

Contrast sensitivity as an outcome measure in patients with subfoveal choroidal neovascularisation due to age-related macular degeneration

“…Positive contrast sensitivity findings have also been reported in small-scale studies of radiation therapy, 57 although other studies, including the largest controlled trial of radiation therapy to date, have reported no significant benefits. 58,59 Other treatment modalities A variety of surgical techniques have been investigated for patients with neovascular AMD. Submacular surgery frequently has poor visual outcomes, [60][61][62] possibly because the CNV is often irreversibly attached to the RPE.…”

Age-Related Macular Degeneration

“…41 One-year follow-up in eyes treated with low-dose externalbeam irradiation showed neither benefit nor harm for subfoveal CNV complicating AMD, 42 and different dosing parameters may be more effective. 43 Transpupillary thermotherapy is under investigation as a potential treatment for occult CNV.…”